Vice Provost and Director of the Biosciences Initiative
Office of the Provost and Executive Vice President for Academic Affairs
Tadataka Yamada Distinguished University Professor of Molecular and Integrative Physiology
Mary Sue Coleman Director of the Life Sciences Institute
Research Professor, Life Sciences Institute
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
Professor of Molecular and Integrative Physiology
[email protected]
Available to mentor
Roger D Cone
Director
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Center MemberCaswell Diabetes Institute
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Lu Z-A, Ploner A, Birgegård A, Eating Disorders Working Group of the Psychiatric Genomics Consortium , Bulik CM, Bergen SE. Schizophr Bull, 2024 Aug 27; 50 (5): 1255 - 1265.Journal ArticleShared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis.
DOI:10.1093/schbul/sbae087 PMID: 38848516 -
Dahir NS, Gui Y, Wu Y, Sweeney PR, Rouault AA, Williams SY, Gimenez LE, Sawyer TK, Joy ST, Mapp AK, Cone RD. J Clin Invest, 2024 Jul 15; 134 (14):Journal ArticleSubthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice.
DOI:10.1172/JCI178250 PMID: 39007271 -
Li L, Hernandez CC, Gimenez LE, Xu B, Dahir NS, Swati , Birnbaum SG, Cone RD, Liu C. 2024 Jun 8;PreprintFunctional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia.
DOI:10.1101/2024.06.07.597973 PMID: 38895206 -
Peisley A, Hernandez CC, Dahir NS, Koepping L, Raczkowski A, Su M, Ghamari-Langroudi M, Ji X, Gimenez LE, Cone RD. 2024 Jun 8;PreprintStructure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States.
DOI:10.1101/2024.06.07.597981 PMID: 38895219 -
Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. J Med Chem, 2024 Feb 22; 67 (4): 2690 - 2711.Journal ArticleNovel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
DOI:10.1021/acs.jmedchem.3c01822 PMID: 38345933 -
Hernandez CC, Gimenez LE, Cone RD. Methods Mol Biol, 2024 2796: 229 - 248.Journal ArticleAutomated Patch Clamp Recordings of GPCR-Gated Ion Channels: Targeting the MC4-R/Kir7.1 Potassium Channel Complex.
DOI:10.1007/978-1-0716-3818-7_14 PMID: 38856905 -
Dahir NS, Gui Y, Wu Y, Sweeney PR, Williams SY, Gimenez LE, Sawyer TK, Joy ST, Mapp AK, Cone RD. bioRxiv, 2023 Dec 7;Journal ArticleInhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.
DOI:10.1101/2023.12.05.570114 PMID: 38106197 -
Wang S, Downing G, Olsen KF, Sawyer TK, Cone RD, Schwendeman SP. J Control Release, 2023 Dec; 364: 589 - 600.Journal ArticleAqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment.
DOI:10.1016/j.jconrel.2023.09.015 PMID: 37678438
Health Lab
A network of proteins found in the central nervous system could be harnessed to increase the effectiveness, and reduce the side effects, of diabetes and weight-loss drugs such as Ozempic and Mounjaro, according to research from the University of Michigan Life Sciences Institute.
