Mrinal K Sarkar, PhD
Assistant Research Scientist
Dermatology
Medical School
[email protected]

Available to mentor

Mrinal K Sarkar, PhD
Assistant Research Scientist
  • Research Overview
  • Recent Publications
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    Research Overview

    • Psoriasis
    • Cutaneous Lupus Erythematosus (CLE)
    • Keratinocytes
    • Type I Interferons
    • Systemic Lupus Erythematosus (SLE)
    • Interferon kappa

    Recent Publications See All Publications
    • Journal Article
      GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
      Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z, Siebert S, Schofield J, McAteer H, Brown SJ, Smith CH, Burden AD, Nelis M, Milani L, Metspalu A, Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT. Nature Communications, 2025 Dec 1; 16 (1): DOI:10.1038/s41467-025-56719-8
      PMID: 40021644
    • Journal Article
      Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
      Oliva M, Sarkar MK, March ME, Saeidian AH, Mentch FD, Hsieh CL, Tang F, Uppala R, Patrick MT, Li Q, Bogle R, Kahlenberg JM, Watson D, Glessner JT, Youssefian L, Vahidnezhad H, Tsoi LC, Hakonarson H, Gudjonsson JE, Smith KM, Riley-Gillis B. Nature Communications, 2025 Dec 1; 16 (1): DOI:10.1038/s41467-025-58310-7
      PMID: 40164604
    • Journal Article
      Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares.
      Krueger JG, Sarkar MK, Lebwohl MG, Morita A, Gordon K, Bogle R, Cole C, Coon A, Langley RG, Warren RB, Mostaghimi A, Strober B, Burden AD, Zheng M, Mangold AR, Anadkat MJ, Barker JN, Merola JF, Tsoi LC, Tang M, Becker K, Delic D, Thoma C, Gudjonsson JE. J Clin Invest, 2025 Jul 1; DOI:10.1172/JCI188530
      PMID: 40591420
    • Preprint
      A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.
      Marella S, Bogle R, Fox J, Tsoi LC, Xing X, Gu Y, Kirma J, Sarkar MK, van Drongelen V, Klein B, Kozlow JH, Harms PW, Gallagher K, Naik S, Rebecca VW, Andersen B, Nakamura M, Kahlenberg JM, Modlin RL, Billi AC, Gudjonsson JE. 2025 May 15; DOI:10.1101/2025.05.10.653184
      PMID: 40463060
    • Preprint
      IL-1 signaling enrichment in inflammatory skin disease loci with higher-risk allele frequencies in African ancestry.
      Tsoi L, Dong Y, Patrick M, Sarkar M, Zhang H, Bogle R, Zhang Z, Dand N, Paulsen M, Ljungman M, Betz RC, Petukhova L, Christiano A, Simpson M, Modlin R, Khanna D, Barker J, Budunova I, Gharaee-Kermani M, Billi A, Elder J, Kahlenberg JM, Gudjonsson J. 2025 Jan 23; DOI:10.21203/rs.3.rs-5724270/v1
      PMID: 39975900
    • Journal Article
      Characterizing the immune infiltrate in secondary syphilis: implications for transmission and pathology
      Gallais Sérézal I, Kirma J, Sarkar MK, Cole C, Xing X, Bogle R, Fox J, Coon A, vanStraalen KR, Dobry C, Xu LH, Kahlenberg JM, Harms PW, Billi AC, Tsoi LC, Giacani L, Gudjonsson JE. Frontiers in Immunology, 2025 Jan 1; 16: DOI:10.3389/fimmu.2025.1549206
      PMID: 40201184
    • Preprint
      Keratin 16 spatially inhibits type I interferon responses in stressed skin.
      Cohen E, Xu Y, Orosco A, Wang D, Johnson CN, Steen K, Sarkar MK, Özlü N, Tsoi LC, Gudjonsson JE, Parent CA, Coulombe PA. 2024 Dec 27; DOI:10.1101/2024.12.27.630544
      PMID: 39763960
    • Proceeding / Abstract / Poster
      342 Molecular characterization of secondary syphilis through bulk, single-cell analyses and identification of the role of MYD88 in cellular responses to Treponema pallidum
      Sérézal IG, Kirma J, Sarkar M, Xing X, Bogle R, Coon A, Harms PW, Tsoi LC, Giacani L, Gudjonsson JE. Journal of Investigative Dermatology, 2024 Nov 22; 144 (12): s287 DOI:10.1016/j.jid.2024.10.351