Available to mentor
The Shea Lab works at the interface of regenerative medicine, biomaterials, and systems biology. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation, promote tissue regeneration or function, and monitor disease initiation or progression.
https://shearesearch.engin.umich.edu/
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Postdoctoral FellowUniversity of Michigan, School of Dentistry, USA
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PhDUniversity of Michigan, USA
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
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Center MemberPrecision Health Initiative
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Center MemberBiointerfaces Institute
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Center MemberBiosciences Initiative
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Center MemberCaswell Diabetes Institute
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Center MemberRegenerative Medicine Resource Center
Of particular emphasis in the lab is:
Applying the controllable microenvironments to in vitro and in vivo models of tissue formation, including nerve regeneration, and islet formation and function.
Engineering nanoparticles or environments to modulate innate and adaptive immune responses for autoimmune and allergic disease, responses to trauma, and to prevent rejection of transplanted cells or tissue.
Developing diagnostic systems for cancer, autoimmune disease, and transplant rejection that can detect immune dysregulation associated with disease onset, and monitor for the response to therapy.
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Nekanti U, Sakthivel PS, Zahedi A, Creasman DA, Nishi RA, Dumont CM, Piltti KM, Guardamondo GL, Hernandez N, Chen X, Song H, Lin X, Martinez J, On L, Lakatos A, Pawar K, David BT, Guo Z, Seidlits SK, Xu X, Shea LD, Cummings BJ, Anderson AJ. NPJ Regen Med, 2024 Mar 18; 9 (1): 12Journal ArticleMultichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI.
DOI:10.1038/s41536-024-00356-0 PMID: 38499577 -
King JL, Urie RR, Morris AH, Rad L, Bealer E, Kasputis T, Shea LD. Biotechnol Bioeng, 2024 Nov; 121 (11): 3600 - 3613.Journal ArticlePolymer scaffolds delineate healthy from diseased states at sites distal from the pancreas in two models of type 1 diabetes.
DOI:10.1002/bit.28824 PMID: 39082734 -
Lietzke AC, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D'Ancona E, Henry-Kanarek B, Reck EC, Arnipalli M, Sidarala V, Walker EM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA. 2024 Jul 29;PreprintLimitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells.
DOI:10.1101/2024.07.26.605318 PMID: 39211191 -
Urie RR, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li JZ, Goldstein DR, Shea LD. Sci Adv, 2024 May 17; 10 (20): eadk6178Journal ArticleBiomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts.
DOI:10.1126/sciadv.adk6178 PMID: 38748794 -
Xu Z, Escalona G, Zhang W, Schrack I, Shea L, Wang X. 2024 Mar 13; 107Proceeding / Abstract / PosterDetecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive in vivo photoacoustic microscopy and OCT
DOI:10.1117/12.2692826 -
Rad LM, Arellano G, Podojil JR, O'Konek JJ, Shea LD, Miller SD. J Allergy Clin Immunol, 2024 Mar; 153 (3): 549 - 559.Journal ArticleEngineering nanoparticle therapeutics for food allergy.
DOI:10.1016/j.jaci.2023.10.013 PMID: 37926124 -
Urie R, Hesse L, Xiao C, Lombard E, Hughes E, Shikanov A, Shea L. American Journal of Obstetrics and Gynecology, 2024 Jan; 230 (1): s610 - s611.Journal Article1167 Sentinel Biomaterials Remotely Monitor The Placental Microenvironment
DOI:10.1016/j.ajog.2023.11.1191 -
Saunders MN, Griffin KV, Kalashnikova I, Kolpek D, Smith DR, Saito E, Cummings BJ, Anderson AJ, Shea LD, Park J. Pain, 2024 Jan 1; 165 (1): 92 - 101.Journal ArticleBiodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury.
DOI:10.1097/j.pain.0000000000002989 PMID: 37463227
