Lonnie Shea
Steven A Goldstein Collegiate Professor of Biomedical Engineering
Professor of Biomedical Engineering
Professor of Chemical Engineering
Professor of Surgery
[email protected]

Available to mentor
Lonnie Shea
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    The Shea Lab works at the interface of regenerative medicine, biomaterials, and systems biology. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation, promote tissue regeneration or function, and monitor disease initiation or progression.

    Links
    • https://shearesearch.engin.umich.edu/
    Qualifications
    • Postdoctoral Fellow
      University of Michigan, School of Dentistry, USA
    • PhD
      University of Michigan, USA
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Precision Health Initiative
    • Center Member
      Rogel Cancer Center
    • Center Member
      Biointerfaces Institute
    • Center Member
      Biosciences Initiative
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Regenerative Medicine Resource Center
    Research Overview

    Of particular emphasis in the lab is:

    Applying the controllable microenvironments to in vitro and in vivo models of tissue formation, including nerve regeneration, and islet formation and function.
    Engineering nanoparticles or environments to modulate innate and adaptive immune responses for autoimmune and allergic disease, responses to trauma, and to prevent rejection of transplanted cells or tissue.
    Developing diagnostic systems for cancer, autoimmune disease, and transplant rejection that can detect immune dysregulation associated with disease onset, and monitor for the response to therapy.

    Recent Publications See All Publications
    • Journal Article
      Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI.
      Nekanti U, Sakthivel PS, Zahedi A, Creasman DA, Nishi RA, Dumont CM, Piltti KM, Guardamondo GL, Hernandez N, Chen X, Song H, Lin X, Martinez J, On L, Lakatos A, Pawar K, David BT, Guo Z, Seidlits SK, Xu X, Shea LD, Cummings BJ, Anderson AJ. NPJ Regen Med, 2024 Mar 18; 9 (1): 12 DOI:10.1038/s41536-024-00356-0
      PMID: 38499577
    • Preprint
      Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells.
      Lietzke AC, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D'Ancona E, Henry-Kanarek B, Reck EC, Arnipalli M, Sidarala V, Walker EM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA. 2024 Jul 29; DOI:10.1101/2024.07.26.605318
      PMID: 39211191
    • Journal Article
      Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts.
      Urie RR, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li JZ, Goldstein DR, Shea LD. Sci Adv, 2024 May 17; 10 (20): eadk6178 DOI:10.1126/sciadv.adk6178
      PMID: 38748794
    • Proceeding / Abstract / Poster
      Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive in vivo photoacoustic microscopy and OCT
      Xu Z, Escalona G, Zhang W, Schrack I, Shea L, Wang X. 2024 Mar 13; 107 DOI:10.1117/12.2692826
    • Journal Article
      Engineering nanoparticle therapeutics for food allergy.
      Rad LM, Arellano G, Podojil JR, O'Konek JJ, Shea LD, Miller SD. J Allergy Clin Immunol, 2024 Mar; 153 (3): 549 - 559. DOI:10.1016/j.jaci.2023.10.013
      PMID: 37926124
    • Journal Article
      1167 Sentinel Biomaterials Remotely Monitor The Placental Microenvironment
      Urie R, Hesse L, Xiao C, Lombard E, Hughes E, Shikanov A, Shea L. American Journal of Obstetrics and Gynecology, 2024 Jan; 230 (1): s610 - s611. DOI:10.1016/j.ajog.2023.11.1191
    • Journal Article
      Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury.
      Saunders MN, Griffin KV, Kalashnikova I, Kolpek D, Smith DR, Saito E, Cummings BJ, Anderson AJ, Shea LD, Park J. Pain, 2024 Jan 1; 165 (1): 92 - 101. DOI:10.1097/j.pain.0000000000002989
      PMID: 37463227
    • Journal Article
      Grand Challenges at the Interface of Engineering and Medicine.
      Subramaniam S, Akay M, Anastasio MA, Bailey V, Boas D, Bonato P, Chilkoti A, Cochran JR, Colvin V, Desai TA, Duncan JS, Epstein FH, Fraley S, Giachelli C, Grande-Allen KJ, Green J, Guo XE, Hilton IB, Humphrey JD, Johnson CR, Karniadakis G, King MR, Kirsch RF, Kumar S, Laurencin CT, Li S, Lieber RL, Lovell N, Mali P, Margulies SS, Meaney DF, Ogle B, Palsson B, A Peppas N, Perreault EJ, Rabbitt R, Setton LA, Shea LD, Shroff SG, Shung K, Tolias AS, van der Meulen MCH, Varghese S, Vunjak-Novakovic G, White JA, Winslow R, Zhang J, Zhang K, Zukoski C, Miller MI. IEEE Open J Eng Med Biol, 2024 5: 1 - 13. DOI:10.1109/OJEMB.2024.3351717
      PMID: 38415197