
Poth Professor of Cutaneous Oncology
Associate Chair, Department of Dermatology
Professor of Dermatology and Professor of Cell and Developmental Biology
[email protected]
Available to mentor
Andrzej Dlugosz, MD

Professor
Work in my lab is focused on basal cell carcinoma, other Hedgehog-driven cancers, and a virus-associated cancer called Merkel cell carcinoma. We have developed and characterized multiple genetically-engineered mouse models to address fundamental questions in cancer biology, including identifying potential cells of origin of cancer, functions of oncogenic signaling in tumor maintenance, significance of cross-talk between signaling pathways in cancer, interactions between tumor cells and their microenvironment, and the regulation of tumor cell fate.
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MDPennsylvania State University College of Medicine
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
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Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE. Nat Commun, 2025 Feb 15; 16 (1): 1663Journal ArticleIdentification of Meibomian gland stem cell populations and mechanisms of aging.
DOI:10.1038/s41467-025-56907-6 PMID: PMC11830078 -
Shafer AM, Kenna E, Golden L-AF, Elhossiny AM, Perry KD, Wilkowski J, Yan W, Kaczkofsky B, McGue J, Bresler SC, Courtney AH, Dalman JM, Galban CJ, Jiang W, Espinoza CE, Chugh R, Iyer MK, Frankel TL, Pasca di Magliano M, Dlugosz AA, Angeles CV. 2025 Feb 4;PreprintAn immunocompetent mouse model of liposarcoma.
DOI:10.1101/2025.01.31.634916 PMID: 40297505 -
Prieto K, Tordesillas L, de Mingo Pulido A, Sell B, Chavez-Chiang O, Aksit I, Harms P, Verhaegen M, Dlugosz A, Patel T, Coarfa C, Tsai K. 2024 Nov 8; a1526 - a1527.Proceeding / Abstract / Poster1363 Evaluation of a novel Merkel cell carcinoma mouse model and response to anti-PD-1 immunotherapy
DOI:10.1136/jitc-2024-sitc2024.1363 -
Sun L, Verhaegen ME, McGue J, Olivei AC, Dlugosz AA, Frankel TL, Harms PW. Lab Invest, 2024 Oct; 104 (10): 102128Journal ArticleDevelopment of a Multiplex Immunofluorescence Assay for Tumor Microenvironment Studies of Human and Murine Merkel Cell Carcinoma.
DOI:10.1016/j.labinv.2024.102128 PMID: PMC11502254 -
Choi JE, Verhaegen ME, Yazdani S, Malik R, Harms PW, Mangelberger D, Tien J, Cao X, Wang Y, Cieślik M, Gurkan J, Yazdani M, Jing X, Juckette K, Su F, Wang R, Zhou B, Apel IJ, Wang S, Dlugosz AA, Chinnaiyan AM. Neoplasia, 2024 Sep; 55: 101019Journal ArticleCorrigendum to "Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma" [Neoplasia, Volume 21, Issue 3 (2019) 322-330].
DOI:10.1016/j.neo.2024.101019 PMID: PMC11261137 -
Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Iomini C, Millar SE. bioRxiv, 2024 Aug 10;Journal ArticleIdentification of Meibomian gland stem cell populations and mechanisms of aging.
DOI:10.1101/2024.08.09.607015 PMID: PMC11326261 -
van Drongelen V, Young K, Gharaee-Kermani M, Plazyo O, Griffin E, Syu L, Xing E, Ward NL, Tsoi LC, Kahlenberg M, Dlugosz A, Gudjonsson JE, Billi A. Journal of Investigative Dermatology, 2024 May 17; 144 (8): s3 - s3.Proceeding / Abstract / Poster016 Investigating therapeutic targeting of the female-biased factor VGLL3 in lupus
DOI:10.1016/j.jid.2024.06.032 -
Verhaegen M, Singer K, Wilbert D, Moore A, Baumbick M, Walter E, Harms PW, Dlugosz A. Journal of Investigative Dermatology, 2024 Jul 20; 144 (8): s146Journal Article838 Immunotherapy-responsive preclinical model of Merkel cell carcinoma in immune-competent mice
DOI:10.1016/j.jid.2024.06.854