Andrzej A Dlugosz, MD

 Andrzej Dlugosz
Poth Professor of Cutaneous Oncology
Associate Chair, Department of Dermatology
Associate Director for Basic Science, Rogel Cancer Center
Professor of Dermatology and Professor of Cell and Developmental Biology, Medical School
Available to mentor
Andrzej A Dlugosz, MD
Andrzej Dlugosz
Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • About

    Work in my lab is focused on basal cell carcinoma, other Hedgehog-driven cancers, and a virus-associated cancer called Merkel cell carcinoma. We have developed and characterized multiple genetically-engineered mouse models to address fundamental questions in cancer biology, including identifying potential cells of origin of cancer, functions of oncogenic signaling in tumor maintenance, significance of cross-talk between signaling pathways in cancer, interactions between tumor cells and their microenvironment, and the regulation of tumor cell fate.

    Qualifications
    • MD
      Pennsylvania State University College of Medicine, USA

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center

    Recent Publications

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    • Proceeding / Abstract / Poster
      0997 VGLL3-TEAD interaction as a therapeutic target in cutaneous lupus
      Van Drongelen V, Griffin E, Rew JE, Young K, Gharaee-Kermani M, Bogle R, Tsoi LC, Kahlenberg M, Dlugosz AA, Gudjonsson JE, Billi AC. Journal of Investigative Dermatology, 2026 Jul 22; 146 (8): s172 DOI:10.1016/j.jid.2026.06.1028
    • Preprint
      An immunocompetent Merkel cell carcinoma model for preclinical studies
      Verhaegen ME, Bhatia S, Singer KL, Baumbick M, Huang P-W, Syu L-J, Wilbert D, Selig A, Farjo GA, Walter E, Wolinski N, Furgal A, Galloway DA, Harms PW, Cieslik M, Dlugosz AA. 2026 Jun 28; bioRxiv, DOI:10.64898/2026.06.25.734228
    • Journal Article
      Spatiotemporal role of GLI2 in driving SHH-medulloblastoma tumorigenesis
      Murad N, Xu Z, Zhang J, Liu X, Ramawickrama P, Tao R, Rivero-Hinojosa S, Schoof M, Schüller U, Chen Q, Rood BR, Packer R, Nair LR, Grachtchouk M, Dlugosz A, Yang J, Taylor MD, Pei H, Pei Y. Neuro Oncology, 2026 Jun 1; 28 (6): 1541 - 1555. DOI:10.1093/neuonc/noag033
      PMID: 41706711
    • Proceeding / Abstract / Poster
      0863 Orthotopic injection of syngeneic melanoma cell lines into mouse ear skin reveals variable engraftment, metastasis, and skin depigmentation
      Holtz C, Kondrachuk O, Syed T, Aqeel J, Dlugosz A, Angeles C, Pedersen E. 2026 May 13;
    • Proceeding / Abstract / Poster
      0868 Anagen-phase skin promotes growth of orthotopically-implanted mouse melanoma cells
      Aqeel J, Kondrachuk O, Holtz C, Syed T, Angeles C, Dlugosz A, Pedersen E. 2026 May 13;
    • Journal Article
      Abstract 6096: Characterization of a novel doxycycline inducible model of EZH2 overexpression in mammary glands
      Eido A, Gonzalez ME, Syu L, Dlugosz AA, Kleer CG. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6096 - 6096. DOI:10.1158/1538-7445.am2026-6096
    • Journal Article
      Does Basal Cell Carcinoma Arise from a Precursor Lesion?
      Wong SY, Harms PW, Dlugosz AA. Journal of Investigative Dermatology, 2026 Apr 1; 146 (4): 905 - 913. DOI:10.1016/j.jid.2025.09.381
      PMID: 41240053
    • Journal Article
      Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice
      Pedersen EA, Grachtchouk M, Harms PW, Furgal AKC, Wilbert D, Hoover A, Hodgson DV, Fiehler K, Alam A, Lingam N, Wong SY, Verhaegen ME, Dlugosz AA. Jid Innovations, 2026 Mar 1; 6 (2): DOI:10.1016/j.xjidi.2025.100441