Frederick G L Huetwell Research Professor of Rheumatology II
Assistant Professor in Internal Medicine
Internal Medicine/Rheumatology
2800 Plymouth Road, Building 20, Room 1822
Ann Arbor, Michigan 48109
[email protected]
2800 Plymouth Road, Building 20, Room 1822
Ann Arbor, Michigan 48109
Available to mentor
Eliza PS Tsou, PhD
Assistant Professor
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PhDUniversity at Buffalo, State University of New York, Buffalo, 2008
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BScNational Taiwan University, Taipei, 2001
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210Journal ArticleSystems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
DOI:10.1038/s41467-023-44645-6 PMID: 38172207 -
van Straalen KR, Ma F, Tsou P-S, Plazyo O, Gharaee-Kermani M, Calbet M, Xing X, Sarkar MK, Uppala R, Harms PW, Wasikowski R, Nahlawi L, Nakamura M, Eshaq M, Wang C, Dobry C, Kozlow JH, Cherry-Bukowiec J, Brodie WD, Wolk K, Uluçkan Ö, Mattichak MN, Pellegrini M, Modlin RL, Maverakis E, Sabat R, Kahlenberg JM, Billi AC, Tsoi LC, Gudjonsson JE. J Clin Invest, 2024 Feb 1; 134 (3):Journal ArticleSingle-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa.
DOI:10.1172/JCI169225 PMID: 38051587 -
Shi B, Tsou P-S, Ma F, Mariani MP, Mattichak MN, LeBrasseur NK, Chini EN, Lafyatis R, Khanna D, Whitfield ML, Gudjonsson JE, Varga J. J Invest Dermatol, 2023 Apr; 143 (4): 661 - 664.e5.Journal ArticleSenescent Cells Accumulate in Systemic Sclerosis Skin.
DOI:10.1016/j.jid.2022.09.652 PMID: 36191640 -
Muraoka S, Brodie MD, Mattichak M, Gurrea Rubio M, Foster C, Amin M, Khanna N, Amin H, Ikari Y, Campbell P, Vichaikul S, Model EN, Omara MM, Petrovski S, Kozicki K, Amarista C, Webber A, Ali M, Palisoc PJ, Hervoso J, Ruth JH, Tsoi LC, Varga J, Gudjonsson J, Khanna D, Fox D, Tsou P. Arthritis Rheumatol., 2025 Jan 1;Journal ArticleTargeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis
DOI:10.1002/art.42973 -
Kortam N, Liang W, Shiple C, Huang S, Gedert R, Clair JS, Sarosh C, Foster C, Tsou P-S, Varga J, Knight JS, Khanna D, Ali RA. Arthritis Res Ther, 2024 Jul 25; 26 (1): 139Journal ArticleElevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog.
DOI:10.1186/s13075-024-03379-6 PMID: 39054558 -
O'Reilly S, Tsou P-S, Varga J. Trends Mol Med, 2024 Dec; 30 (12): 1113 - 1125.Journal ArticleSenescence and tissue fibrosis: opportunities for therapeutic targeting.
DOI:10.1016/j.molmed.2024.05.012 PMID: 38890028 -
Hile G, Ma F, Tsou P, Gharaee-Kermani M, Zhang L, Victory A, Hurst A, Xu B, Pedersen E, Wasikowski R, Berthier C, Ognenovski V, Nakamura M, Billi A, Gudjonsson JE, Kahlenberg M. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s150Proceeding / Abstract / PosterLB860 Cross-disease comparison of dermatomyositis and SLE identifies non-classical monocytes and JAK-1 signaling as drivers of endothelial cell death in DM skin
DOI:10.1016/j.jid.2024.06.1240 -
Gurrea-Rubio M, Wang Q, Mills EA, Wu Q, Pitt D, Tsou P-S, Fox DA, Mao-Draayer Y. Int J Mol Sci, 2024 Feb 20; 25 (5):Journal ArticleSiponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways.
DOI:10.3390/ijms25052454 PMID: 38473703
Health Lab
Targeting and blocking the sCD13 protein from interacting with the B1R protein can pave the way for new fibrosis and systemic sclerosis treatments.
