JoAnn M Sekiguchi, PhD

 JoAnn Sekiguchi
Associate Professor of Internal Medicine
Associate Professor of Human Genetics and Program Director
Human Genetics
Medical School
[email protected]
Available to mentor
JoAnn M Sekiguchi, PhD
JoAnn Sekiguchi
Associate Professor
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    • Recent Publications

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    • Journal Article
      Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder
      Hartlerode AJ, Mostafa AM, Orban SK, Benedeck R, Campbell K, Hoenerhoff MJ, Ferguson DO, Sekiguchi JM. Human Molecular Genetics, 2024 Sep 15; 33 (18): 1605 - 1617. DOI:10.1093/hmg/ddae101
    • Journal Article
      Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
      Melnick AF, Mullin C, Lin K, McCarter AC, Liang S, Liu YE, Wang Q, Jerome NA, Choe E, Kunnath N, Bodanapu G, Akter F, Magnuson B, Kumar S, Lombard DB, Muntean AG, Ljungman M, Sekiguchi JA, Ryan RJH, Chiang MY. Blood, 2023 Dec 21; 142 (25): 2159 - 2174. DOI:10.1182/blood.2023020144
      PMID: 37616559
    • Journal Article
      Editorial: Interplay between oncomicrobes, the microbiota and the immune system: impact on responses to cancer immunotherapy
      Dorta-Estremera SM, Peterson EA, Pérez-Santiago J, Sekiguchi JAM. Frontiers in Immunology, 2023 Jan 1; 14: DOI:10.3389/fimmu.2023.1269020
      PMID: 37654498
    • Journal Article
      Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease
      Saunders RA, Michniacki TF, Hames C, Moale HA, Wilke C, Kuo ME, Nguyen J, Hartlerode AJ, Moore BB, Sekiguchi JAM. Scientific Reports, 2021 Dec 1; 11 (1): DOI:10.1038/s41598-021-83531-3
      PMID: 33608602
    • Journal Article
      The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis
      Ferguson DO, Sekiguchi J, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. 2026 Jun 12;
    • Journal Article
      Proteolytic footprinting of vaccinia topoisomerase bound to DNA
      Sekiguchi JA, Shuman S. Journal of Biological Chemistry, 1995 May 12; 270 (19): 11636 - 11645. DOI:10.1074/jbc.270.19.11636
      PMID: 7744804

    Featured News & Stories
    Department News

    Highlighted Publications: August - December 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - September 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - June 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.