JoAnn M Sekiguchi, PhD

 JoAnn Sekiguchi
Associate Professor of Internal Medicine
Associate Professor of Human Genetics and Program Director
Human Genetics
Medical School
Office:
MM Medical School
Human Genetics
1241 Catherine St, 4909 Buhl
Ann Arbor, MI 48109-5618
Email:
[email protected]
Phone:
Available to mentor
JoAnn M Sekiguchi, PhD
JoAnn Sekiguchi
Associate Professor
  • Recent Publications

  • Manage Your Profile

    • Recent Publications

     See All Publications
    • Journal Article
      Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.
      DeFoer MB, Mostafa AM, Hartlerode AJ, Orban SK, McDonough K, Quirk S, Ferguson BKL, Ferguson DO, Sekiguchi JM. Hum Mol Genet, 2025 Nov 18; 34 (23): 1964 - 1978. DOI:10.1093/hmg/ddaf154
      PMID: PMC13377461
    • Journal Article
      Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder
      Hartlerode AJ, Mostafa AM, Orban SK, Benedeck R, Campbell K, Hoenerhoff MJ, Ferguson DO, Sekiguchi JM. Human Molecular Genetics, 2024 Sep 15; 33 (18): 1605 - 1617. DOI:10.1093/hmg/ddae101
    • Journal Article
      Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
      Melnick AF, Mullin C, Lin K, McCarter AC, Liang S, Liu YE, Wang Q, Jerome NA, Choe E, Kunnath N, Bodanapu G, Akter F, Magnuson B, Kumar S, Lombard DB, Muntean AG, Ljungman M, Sekiguchi JA, Ryan RJH, Chiang MY. Blood, 2023 Dec 21; 142 (25): 2159 - 2174. DOI:10.1182/blood.2023020144
      PMID: 37616559
    • Presentation
      Mechanistic insights into the roles of the Artemis and MRE11 nucleases in V(D)J recombination and genome stability
      Sekiguchi J. 2026 Jun 30;
    • Presentation
      Novel roles for the MRE11 DNA nuclease in lymphocyte development, hematopoiesis and DNA repair
      Sekiguchi J. 2026 Jun 30;
    • Journal Article
      Editorial: Interplay between oncomicrobes, the microbiota and the immune system: impact on responses to cancer immunotherapy
      Dorta-Estremera SM, Peterson EA, Pérez-Santiago J, Sekiguchi JAM. Frontiers in Immunology, 2023 Jan 1; 14: DOI:10.3389/fimmu.2023.1269020
      PMID: 37654498
    • Journal Article
      Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease
      Saunders RA, Michniacki TF, Hames C, Moale HA, Wilke C, Kuo ME, Nguyen J, Hartlerode AJ, Moore BB, Sekiguchi JAM. Scientific Reports, 2021 Dec 1; 11 (1): DOI:10.1038/s41598-021-83531-3
      PMID: 33608602
    • Presentation
      MRE11 promotes tumorigenesis by facilitating resistance to oncogene-induced replication stress
      Sekiguchi J. 2026 Jun 30;

    Featured News & Stories
    Department News

    Highlighted Publications: August - December 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - September 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - June 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.