George A Mashour
Senior Associate Dean for Faculty and Faculty Development
Professor of Anesthesiology
Program Director, Anesthesiology
Professor of Pharmacology
Medical School
[email protected]

Available to mentor
George A Mashour
Senior Associate Dean
  • Qualifications
  • Research Overview
  • Recent Publications
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    Qualifications
    • MD, PhD
      Georgetown University
    Research Overview

    Multidisciplinary approaches to the study of consciousness
    - Network mechanisms of consciousness and unconsciousness
    -Theories of consciousness
    - Interfaces of sleep neurobiology and general anesthesia
    - Intraoperative awareness and metrics of consciousness

    Recent Publications See All Publications
    • Journal Article
      Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex.
      Silverstein BH, Kolbman N, Nelson A, Liu T, Guzzo P, Gilligan J, Lee U, Mashour GA, Vanini G, Pal D. Transl Psychiatry, 2025 Mar 25; 15 (1): 93 DOI:10.1038/s41398-025-03308-4
      PMID: PMC11933319
    • Journal Article
      Regulation of REM and NREM Sleep by Preoptic Glutamatergic Neurons.
      Mondino A, Jadidian A, Toth BA, Hambrecht-Wiedbusch VS, Floran-Garduno L, Li D, York AK, Torterolo P, Pal D, Burgess CR, Mashour GA, Vanini G. Sleep, 2025 May 26; DOI:10.1093/sleep/zsaf141
      PMID: 40417998
    • Journal Article
      Pictorial representation of illness and self measure (PRISM): A putative transdiagnostic tool for evaluating therapeutic effects of psychedelic treatments.
      Pouyan N, Aday JS, Harte SE, Kaplan CM, Williams DA, Glynos NG, Herberholz M, Kruger DJ, Barron J, Mashour GA, Clauw DJ, Preller KH, Schrepf A, Boehnke KF. J Psychopharmacol, 2025 May; 39 (5): 489 - 498. DOI:10.1177/02698811251330763
      PMID: 40323119
    • Preprint
      Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats.
      Glynos NG, Huels ER, Nelson A, Kim Y, Kennedy RT, Mashour GA, Pal D. 2025 Feb 15; DOI:10.1101/2024.04.19.589047
      PMID: 38712161
    • Journal Article
      Environmental and patient safety outcomes of a health-system Green Anesthesia Initiative (GAIA): a retrospective observational cohort study.
      Colquhoun DA, Hovord D, Rachel R, Yuan Y, Mentz GB, Koppera P, Dubovoy TZ, Picton P, Mashour GA. Lancet Planet Health, 2025 Feb; 9 (2): e124 - e133. DOI:10.1016/S2542-5196(24)00331-0
      PMID: PMC11881991
    • Preprint
      Psychedelic-mediated Reversal of General Anesthesia and Restoration of Brain Dynamics in Rat
      Huels ER, Kolbman N, Fields CW, Nelson AG, Jackson H, Liu T, Mashour GA, Pal D. 2025 Jan 26; bioRxiv, DOI:10.1101/2025.01.22.632279
    • Journal Article
      Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-Center Retrospective Cohort and Genome-Wide Association Study.
      Douville NJ, Jewell ES, Zhao X, Colquhoun DA, Bertucci-Richter E, Zollner S, Davis RP, Kumar SS, Mashour GA. Anesthesiology, 2025 Jun 9; DOI:10.1097/ALN.0000000000005602
      PMID: 40489632
    • Journal Article
      Corrigendum to "Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats" [Br J Anaesth 132 (2024) 1248-1259].
      Silverstein BH, Parkar A, Groenhout T, Fracz Z, Fryzel AM, Fields CW, Nelson A, Liu T, Vanini G, Mashour GA, Pal D. Br J Anaesth, 2025 Jan; 134 (1): 257 DOI:10.1016/j.bja.2024.10.004
      PMID: PMC11832911
    Featured News & Stories George A. Mashour, M.D., Ph.D.
    Medical School News
    George A. Mashour, M.D., Ph.D., appointed interim executive vice dean for academic affairs/chief academic officer
    On Dec. 5, the Board of Regents approved the appointment of George A. Mashour, M.D., Ph.D., as interim executive vice dean for academic affairs (EVDAA) in the Medical School, effective January 1, 2025. He also will serve as interim chief academic officer (CAO) for Michigan Medicine. He takes over EVDAA/CAO duties from Debra F. Weinstein, M.D., who is leaving Michigan Medicine at the end of this year to become president and chief executive officer of the Accreditation Council for Graduate Medical Education
         brain drawn
    Health Lab
    The brain in balance
    In a recent study, using network neuroscience, investigators found a way to objectively determine the balance of integration and segregation in fMRI-measured brain signals during wakefulness as well as during sleep and anesthesia.
         88% Reduction in GHG Emissions
    Department News
    Green Anesthesia Initiative exceeds lofty goals for reduction in emissions
    The Department of Anesthesiology’s Green Anesthesia Initiative (GAIA) has taken an ambitious approach to environmental sustainability resulting in an 88% reduction of inhaled anesthetic greenhouse gas emissions.
    Department News
    George Mashour, MD, PhD, featured on the StarTalk Podcast
    George Mashour, MD, PhD at the University of Michigan Department of Anesthesiology featured on the StarTalk Podcast.
    Department News
    Green Anesthesia Initiative quickly shows progress
    Is there a common path to the psychedelic experience?
         Research By the Numbers FY22.jpg
    Department News
    U-M Anesthesiology ranked #1 in NIH funding for eighth consecutive year with more than $22M in funding
    Three researchers — Drs. George Mashour, Chad Brummett, and David Williams — ranked in top 7 for PI funding.