Steven K Huang, MD
Professor of Internal Medicine and Medical Director
UMMG
Division of Pulmonary and Critical Care Medicine
6301 MSRB III, 1150 W Medical Center Dr
Ann Arbor, MI 48109
[email protected]

Available to mentor
Steven K Huang, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Pulmonary and Critical Care Medicine Fellow
      University of Michigan–Ann Arbor, Ann Arbor, 2007
    • Residency
      Northwestern Memorial Hospital, Chicago, 2004
    • Internship
      Northwestern Memorial Hospital, Chicago, 2002
    Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    Research Overview

    Our laboratory investigates how epigenetic changes contribute to the development of chronic lung diseases. We study how DNA methylation patterns are altered in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and how differential methylation of specific genes contribute to IPF pathogenesis. We also investigate how air pollution and particulate matter affect DNA methylation and contribute to lung fibrosis and asthma.

    Links
    • http://stevenhuanglab.com/
    Recent Publications See All Publications
    • Journal Article
      Differences in the DNA methylome of T cells in adults with asthma of varying severity.
      Liao Y, Cavalcante RG, Waller JB, Deng F, Scruggs AM, Huang YJ, Atasoy U, Chen Y, Huang SK. Clin Epigenetics, 2024 Oct 8; 16 (1): 139 DOI:10.1186/s13148-024-01750-7
      PMID: 39380119
    • Journal Article
      Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis.
      Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Nat Commun, 2024 Jun 27; 15 (1): 5449 DOI:10.1038/s41467-024-49545-x
      PMID: 38937456
    • Journal Article
      Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation.
      Druso JE, MacPherson MB, Chia SB, Elko E, Aboushousha R, Seward DJ, Abdelhamid H, Erickson C, Corteselli E, Tarte M, Peng Z, Bernier D, Zito E, Shoulders MD, Thannickal VJ, Huang S, van der Vliet A, Anathy V, Janssen-Heininger YMW. Am J Respir Cell Mol Biol, 2024 Nov; 71 (5): 589 - 602. DOI:10.1165/rcmb.2023-0379OC
      PMID: 39042020
    • Journal Article
      MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution.
      Fortier SM, Walker NM, Penke LR, Baas JD, Shen Q, Speth JM, Huang SK, Zemans RL, Bennett AM, Peters-Golden M. J Clin Invest, 2024 Mar 21; 134 (10): DOI:10.1172/JCI172826
      PMID: 38512415
    • Proceeding / Abstract / Poster
      Adenovirus TGFβ1-induced Profibrotic Responses in Human Lung Fibroblasts - Potential Role of Circadian Clock Component REV-ERBα
      Prasad C, Huang SK, Burris TP, Sundar IK. 2024 May; a2485 - a2485. DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2485
    • Journal Article
      Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues.
      Cruz LC, Habibovic A, Dempsey B, Massafera MP, Janssen-Heininger YMW, Lin M-CJ, Hoffman ET, Weiss DJ, Huang SK, van der Vliet A, Meotti FC. Redox Biol, 2024 May; 71: 103102 DOI:10.1016/j.redox.2024.103102
      PMID: 38430684
    • Proceeding / Abstract / Poster
      Imbalance of DNA Methyltransferases (DNMTS) and Ten-eleven Translocation (TET) Enzymes Contribute to the Altered DNA Methylation Profile of Fibrotic Lung Fibroblasts
      Boateng E, Scruggs AM, Ridenour H, Ligresti G, Huang SK. 2024 May; a2588 - a2588. DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2588
    • Proceeding / Abstract / Poster
      Loss of ERG in Capillary Endothelial Cells Is Associated With cGAS-STING Pathway Activation and Aberrant Lung Fibrosis Resolution'
      Raslan AA, Schmottlach J, Elbasiony O, Hong J, Caporarello N, Huang SK, Ligresti G. 2024 May; a4728 - a4728. DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4728