,
Available to mentor
Dr. Wu joined the Department of Molecular & Integrative Physiology in 2013. She is currently the Jessica Schwartz Collegiate Professor in the Life Sciences, a research associate professor of Life Sciences Institute (LSI), a member of the Cellular & Molecular Biology Program (CMB), Program in Biomedical Sciences (PIBS) and Center for Cell Plasticity and Organ Design.
She received her Bachelor of Science in Biology from University of Science and Technology of China and then her Ph.D. in Biological Chemistry from the University of Michigan, respectively. After her Ph.D, Jun subsequently worked with Bruce Spiegelman at Dana-Farber Cancer Institute and Harvard Medical School as a postdoctoral fellow and instructor.
https://www.lsi.umich.edu/science/our-labs/wu-lab
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Research FellowDana-Farber Cancer Institute, Harvard Medical School, Boston, 2011
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PhD, Biological ChemistryUniversity of Michigan, Ann Arbor, 2007
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BSUniversity of Science & Technology of China, Hefei, 2001
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberSamuel and Jean Frankel Cardiovascular Center
Investigating a beige-selective immune-adipose interaction and studying a novel function of nicotinic acetylcholine receptors in energy metabolism (R01DK107583).
Investigate the mechanistic details how the nonneuronal cholinergic signaling through CHRNA2 is activated, mediated and plays an adaptive/protective role in the context of alcoholic liver disease (ALD) (R01AA028761).
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Ma Y, Jun H, Wu J. Trends Immunol, 2022 Sep; 43 (9): 718 - 727.Journal ArticleImmune cell cholinergic signaling in adipose thermoregulation and immunometabolism.
DOI:10.1016/j.it.2022.07.006 PMID: 35931611 -
Ma Y, Liu S, Jun H, Wu J. Trends Cell Biol, 2022 Jun; 32 (6): 479 - 489.Journal ArticleCHRNA2: a new paradigm in beige thermoregulation and metabolism.
DOI:10.1016/j.tcb.2021.11.009 PMID: 34952750 -
Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, Kennedy RT, Maillard I, Ye L, Jun H, Wu J. EMBO J, 2021 Dec 15; 40 (24): e106061Journal ArticleAcetylcholine-synthesizing macrophages in subcutaneous fat are regulated by β2 -adrenergic signaling.
DOI:10.15252/embj.2020106061 PMID: 34459015 -
Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J. Dev Cell, 2020 Jul 6; 54 (1): 106 - 116.e5.Journal ArticleAdrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
DOI:10.1016/j.devcel.2020.05.017 PMID: 32533922 -
Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, Kim D-I, Emont MP, Zestos AG, Cho J-S, Liu J, Kennedy RT, Maillard I, Xu XZS, Wu J. Nat Med, 2018 Jun; 24 (6): 814 - 822.Journal ArticleAn immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.
DOI:10.1038/s41591-018-0032-8 PMID: 29785025 -
Jiang J, Emont MP, Jun H, Qiao X, Liao J, Kim D-I, Wu J. Metabolism, 2017 Dec; 77: 58 - 64.Journal ArticleCinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming.
DOI:10.1016/j.metabol.2017.08.006 PMID: 29046261 -
Emont MP, Yu H, Jun H, Hong X, Maganti N, Stegemann JP, Wu J. Endocrinology, 2015 Dec; 156 (12): 4761 - 4768.Journal ArticleUsing a 3D Culture System to Differentiate Visceral Adipocytes In Vitro.
DOI:10.1210/en.2015-1567 PMID: 26425808 -
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang A-H, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Cell, 2012 Jul 20; 150 (2): 366 - 376.Journal ArticleBeige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
DOI:10.1016/j.cell.2012.05.016 PMID: 22796012
