Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]
Available to mentor
Shaomeng Wang
Professor
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
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Chen Z, Wang M, Wu D, Bai L, Xu T, Metwally H, Wang Y, McEachern D, Zhao L, Li R, Takyi-Williams J, Wang M, Wang L, Li Q, Wen B, Sun D, Wang S. J Med Chem, 2024 Apr 11; 67 (7): 5275 - 5304.Journal ArticleDiscovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression.
DOI:10.1021/acs.jmedchem.3c02124 PMID: 38477974 -
Chen Z, Wang M, Wu D, Zhao L, Metwally H, Jiang W, Wang Y, Bai L, McEachern D, Luo J, Wang M, Li Q, Matvekas A, Wen B, Sun D, Chinnaiyan AM, Wang S. J Med Chem, 2024 Apr 11; 67 (7): 5351 - 5372.Journal ArticleDiscovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer.
DOI:10.1021/acs.jmedchem.3c01789 PMID: 38530938 -
Rasool RU, O'Connor CM, Das CK, Alhusayan M, Verma BK, Islam S, Frohner IE, Deng Q, Mitchell-Velasquez E, Sangodkar J, Ahmed A, Linauer S, Mudrak I, Rainey J, Zawacki KP, Suhan TK, Callahan CG, Rebernick R, Natesan R, Siddiqui J, Sauter G, Thomas D, Wang S, Taylor DJ, Simon R, Cieslik M, Chinnaiyan AM, Busino L, Ogris E, Narla G, Asangani IA. Nat Commun, 2023 Aug 29; 14 (1): 5253Journal ArticleLoss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
DOI:10.1038/s41467-023-40760-6 PMID: 37644036 -
Zheng C, Rej RK, Wang M, Huang L, Fernandez-Salas E, Yang C-Y, Wang S. ACS Med Chem Lett, 2023 Oct 12; 14 (10): 1389 - 1395.Journal ArticleDiscovery of Pyrrolo[2,3-c]pyridines as Potent and Reversible LSD1 Inhibitors.
DOI:10.1021/acsmedchemlett.3c00292 PMID: 37849536 -
Xiang W, Zhao L, Han X, Xu T, Kregel S, Wang M, Miao B, Qin C, Wang M, McEachern D, Lu J, Bai L, Yang C-Y, Kirchhoff PD, Takyi-Williams J, Wang L, Wen B, Sun D, Ator M, Mckean R, Chinnaiyan AM, Wang S. J Med Chem, 2023 Sep 28; 66 (18): 13280 - 13303.Journal ArticleDiscovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer.
DOI:10.1021/acs.jmedchem.3c01264 PMID: 37683104 -
Chen Z, Hu B, Rej RK, Wu D, Acharyya RK, Wang M, Xu T, Lu J, Metwally H, Wang Y, McEachern D, Bai L, Gersch CL, Wang M, Zhang W, Li Q, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2023 Sep 14; 66 (17): 12559 - 12585.Journal ArticleDiscovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity.
DOI:10.1021/acs.jmedchem.3c01186 PMID: 37647546 -
Ding K, Wang S, Georg GI, Portoghese PS, Lindsley CW. J Med Chem, 2023 Sep 14; 66 (17): 11589 - 11590.Journal ArticleIn Memory of Professor Hualiang Jiang.
DOI:10.1021/acs.jmedchem.3c01378 PMID: 37646574 -
Yang L, Tu W, Huang L, Miao B, Kaneshige A, Jiang W, Leng L, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2023 Aug 10; 66 (15): 10761 - 10781.Journal ArticleDiscovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity.
DOI:10.1021/acs.jmedchem.3c00953 PMID: 37523716
