Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]
Available to mentor
Shaomeng Wang, PhD
Professor
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
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Leng L, Tu W, Yang L, Huang L, Wang M, Meagher JL, Chinnaswamy K, Allu SR, Rej RK, Tošović J, Harikrishnan L, Li Z, Sui Z, Stuckey JA, Wang S. J Med Chem, 2025 Jan 2;Journal ArticleDiscovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders.
DOI:10.1021/acs.jmedchem.4c01903 PMID: 39745064 -
Yang L, Tu W, Leng L, Huang L, Jiang W, Wang M, Wang Y, Meagher JL, Chinnaswamy K, Stuckey JA, Wang M, Wen B, Sun D, Harikrishnan L, Strickland C, Rice C, Orth P, Sui Z, Wang S. J Med Chem, 2025 Jan 2;Journal ArticleDiscovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers.
DOI:10.1021/acs.jmedchem.4c01904 PMID: 39745073 -
Rej RK, Hu B, Chen Z, Acharyya RK, Wu D, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Nishimura LS, Gersch CL, Wang M, Wen B, Sun D, Carlson K, Katzenellenbogen JA, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Rae JM, Wang S. J Med Chem, 2024 Dec 12; 67 (23): 20933 - 20965.Journal ArticleDiscovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).
DOI:10.1021/acs.jmedchem.4c01401 PMID: 39585895 -
Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, Yang H, Pitter M, Yu J, Liao P, Zhou J, Vatan L, Grove S, Wei S, Vigil T, Shah YM, Mortensen R, Kryczek I, Garmire L, Sivaccumar JP, Ramesh AK, Zhang N, An Z, Wang S, Zou W. Cancer Cell, 2024 Dec 9; 42 (12): 2032 - 2044.e6.Journal ArticleItaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance.
DOI:10.1016/j.ccell.2024.10.010 PMID: 39515327 -
Wei X, Lu Y, Lin LL, Zhang C, Chen X, Wang S, Wu SA, Li ZJ, Quan Y, Sun S, Qi L. Nat Commun, 2024 Jan 22; 15 (1): 659Journal ArticleProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
DOI:10.1038/s41467-024-44948-2 PMID: 38253565 -
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang C-Y, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2024 Nov 28; 67 (22): 20495 - 20513.Journal ArticleDiscovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
DOI:10.1021/acs.jmedchem.4c01946 PMID: 39509603 -
Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2024 Nov 14; 67 (21): 19010 - 19037.Journal ArticleDiscovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer.
DOI:10.1021/acs.jmedchem.4c01521 PMID: 39485242 -
Aguilar A, Yang J, Li Y, McEachern D, Huang L, Razzouk S, Wang S. J Med Chem, 2024 Nov 14; 67 (21): 19503 - 19518.Journal ArticleDiscovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia.
DOI:10.1021/acs.jmedchem.4c01818 PMID: 39480241
