Shaomeng Wang, PhD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]

Available to mentor

Shaomeng Wang, PhD
Professor
  • Center Memberships
  • Recent Publications
  • Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center
    Recent Publications See All Publications
    • Journal Article
      Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
      Wei X, Lu Y, Lin LL, Zhang C, Chen X, Wang S, Wu SA, Li ZJ, Quan Y, Sun S, Qi L. Nat Commun, 2024 Jan 22; 15 (1): 659 DOI:10.1038/s41467-024-44948-2
      PMID: 38253565
    • Journal Article
      Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).
      Rej RK, Hu B, Chen Z, Acharyya RK, Wu D, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Nishimura LS, Gersch CL, Wang M, Wen B, Sun D, Carlson K, Katzenellenbogen JA, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Rae JM, Wang S. J Med Chem, 2024 Nov 25; DOI:10.1021/acs.jmedchem.4c01401
      PMID: 39585895
    • Journal Article
      Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders.
      Li Z, Harikrishnan LS, Xu G, Samanta D, Clemente JC, Leng L, Tu W, Yang L, Huang L, Wang M, Wang S, Deng Q, Behshad E, Nagilla R, Orth P, Rice C, Strickland C, Mohammad HP, Priestley ES, Sui Z. J Med Chem, 2024 Nov 21; DOI:10.1021/acs.jmedchem.4c01878
      PMID: 39570797
    • Journal Article
      Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer.
      Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2024 Nov 14; 67 (21): 19010 - 19037. DOI:10.1021/acs.jmedchem.4c01521
      PMID: 39485242
    • Journal Article
      Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia.
      Aguilar A, Yang J, Li Y, McEachern D, Huang L, Razzouk S, Wang S. J Med Chem, 2024 Nov 14; 67 (21): 19503 - 19518. DOI:10.1021/acs.jmedchem.4c01818
      PMID: 39480241
    • Journal Article
      Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119].
      Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Neoplasia, 2024 Nov; 57: 101064 DOI:10.1016/j.neo.2024.101064
      PMID: 39389678
    • Journal Article
      IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma.
      Sun J, Corradini S, Azab F, Shokeen M, Muz B, Miari KE, Maksimos M, Diedrich C, Asare O, Alhallak K, Park C, Lubben B, Chen Y, Adebayo O, Bash H, Kelley S, Fiala M, Bender DE, Zhou H, Wang S, Vij R, Williams MTS, Azab AK. Leukemia, 2024 Nov; 38 (11): 2355 - 2365. DOI:10.1038/s41375-024-02391-8
      PMID: 39215060
    • Journal Article
      Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?
      Sun D, Macedonia C, Chen Z, Chandrasekaran S, Najarian K, Zhou S, Cernak T, Ellingrod VL, Jagadish HV, Marini B, Pai M, Violi A, Rech JC, Wang S, Li Y, Athey B, Omenn GS. J Med Chem, 2024 Sep 26; 67 (18): 16035 - 16055. DOI:10.1021/acs.jmedchem.4c01684
      PMID: 39253942