Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]
Available to mentor
Shaomeng Wang, PhD
Professor
-
Center MemberCenter for Computational Medicine and Bioinformatics
-
Center MemberRogel Cancer Center
-
Wei X, Lu Y, Lin LL, Zhang C, Chen X, Wang S, Wu SA, Li ZJ, Quan Y, Sun S, Qi L. Nat Commun, 2024 Jan 22; 15 (1): 659Journal ArticleProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
DOI:10.1038/s41467-024-44948-2 PMID: 38253565 -
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang C-Y, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2024 Nov 7;Journal ArticleDiscovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
DOI:10.1021/acs.jmedchem.4c01946 PMID: 39509603 -
Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Neoplasia, 2024 Nov; 57: 101064Journal ArticleCorrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119].
DOI:10.1016/j.neo.2024.101064 PMID: 39389678 -
Aguilar A, Yang J, Li Y, McEachern D, Huang L, Razzouk S, Wang S. J Med Chem, 2024 Oct 31;Journal ArticleDiscovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia.
DOI:10.1021/acs.jmedchem.4c01818 PMID: 39480241 -
Sun D, Macedonia C, Chen Z, Chandrasekaran S, Najarian K, Zhou S, Cernak T, Ellingrod VL, Jagadish HV, Marini B, Pai M, Violi A, Rech JC, Wang S, Li Y, Athey B, Omenn GS. J Med Chem, 2024 Sep 26; 67 (18): 16035 - 16055.Journal ArticleCan Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?
DOI:10.1021/acs.jmedchem.4c01684 PMID: 39253942 -
Wang L, Yang H, Wang C, Wang M, Huang J, Nyunt T, Osorio C, Sun S-Y, Pacifici M, Lefebvre V, Moore DC, Wang S, Yang W. FASEB J, 2024 Sep 15; 38 (17): e70013Journal ArticleSHP2 ablation mitigates osteoarthritic cartilage degeneration by promoting chondrocyte anabolism through SOX9.
DOI:10.1096/fj.202400642R PMID: 39225365 -
Choi JE, Verhaegen ME, Yazdani S, Malik R, Harms PW, Mangelberger D, Tien J, Cao X, Wang Y, Cieślik M, Gurkan J, Yazdani M, Jing X, Juckette K, Su F, Wang R, Zhou B, Apel IJ, Wang S, Dlugosz AA, Chinnaiyan AM. Neoplasia, 2024 Sep; 55: 101019Journal ArticleCorrigendum to "Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma" [Neoplasia, Volume 21, Issue 3 (2019) 322-330].
DOI:10.1016/j.neo.2024.101019 PMID: 38943995 -
Krempski J, Yamani A, Thota LNR, Marella S, Ganesan V, Sharma A, Kaneshige A, Bai L, Zhou H, Foster PS, Wang S, Obi AT, Hogan SP. J Allergy Clin Immunol, 2024 Sep; 154 (3): 719 - 734.Journal ArticleIL-4-STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock.
DOI:10.1016/j.jaci.2024.05.009 PMID: 38777155
