Shaomeng Wang
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]

Available to mentor

Shaomeng Wang
Professor
  • Center Memberships
  • Recent Publications
  • Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center
    Recent Publications See All Publications
    • Journal Article
      Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
      Rasool RU, O'Connor CM, Das CK, Alhusayan M, Verma BK, Islam S, Frohner IE, Deng Q, Mitchell-Velasquez E, Sangodkar J, Ahmed A, Linauer S, Mudrak I, Rainey J, Zawacki KP, Suhan TK, Callahan CG, Rebernick R, Natesan R, Siddiqui J, Sauter G, Thomas D, Wang S, Taylor DJ, Simon R, Cieslik M, Chinnaiyan AM, Busino L, Ogris E, Narla G, Asangani IA. Nat Commun, 2023 Aug 29; 14 (1): 5253 DOI:10.1038/s41467-023-40760-6
      PMID: 37644036
    • Journal Article
      Discovery of Pyrrolo[2,3-c]pyridines as Potent and Reversible LSD1 Inhibitors.
      Zheng C, Rej RK, Wang M, Huang L, Fernandez-Salas E, Yang C-Y, Wang S. ACS Med Chem Lett, 2023 Oct 12; 14 (10): 1389 - 1395. DOI:10.1021/acsmedchemlett.3c00292
      PMID: 37849536
    • Journal Article
      Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer.
      Xiang W, Zhao L, Han X, Xu T, Kregel S, Wang M, Miao B, Qin C, Wang M, McEachern D, Lu J, Bai L, Yang C-Y, Kirchhoff PD, Takyi-Williams J, Wang L, Wen B, Sun D, Ator M, Mckean R, Chinnaiyan AM, Wang S. J Med Chem, 2023 Sep 28; 66 (18): 13280 - 13303. DOI:10.1021/acs.jmedchem.3c01264
      PMID: 37683104
    • Journal Article
      Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity.
      Chen Z, Hu B, Rej RK, Wu D, Acharyya RK, Wang M, Xu T, Lu J, Metwally H, Wang Y, McEachern D, Bai L, Gersch CL, Wang M, Zhang W, Li Q, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2023 Sep 14; 66 (17): 12559 - 12585. DOI:10.1021/acs.jmedchem.3c01186
      PMID: 37647546
    • Journal Article
      In Memory of Professor Hualiang Jiang.
      Ding K, Wang S, Georg GI, Portoghese PS, Lindsley CW. J Med Chem, 2023 Sep 14; 66 (17): 11589 - 11590. DOI:10.1021/acs.jmedchem.3c01378
      PMID: 37646574
    • Journal Article
      Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity.
      Yang L, Tu W, Huang L, Miao B, Kaneshige A, Jiang W, Leng L, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2023 Aug 10; 66 (15): 10761 - 10781. DOI:10.1021/acs.jmedchem.3c00953
      PMID: 37523716
    • Journal Article
      Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
      Han X, Zhao L, Xiang W, Miao B, Qin C, Wang M, Xu T, McEachern D, Lu J, Wang Y, Metwally H, Yang C-Y, Kirchhoff PD, Wang L, Matvekas A, Takyi-Williams J, Wen B, Sun D, Ator M, Mckean R, Wang S. J Med Chem, 2023 Jul 13; 66 (13): 8822 - 8843. DOI:10.1021/acs.jmedchem.3c00405
      PMID: 37382562
    • Journal Article
      Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges.
      Rej RK, Thomas JE, Acharyya RK, Rae JM, Wang S. J Med Chem, 2023 Jul 13; 66 (13): 8339 - 8381. DOI:10.1021/acs.jmedchem.3c00136
      PMID: 37377342