Andrew D Schrepf, PhD
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About
Dr. Schrepf is an Assistant Professor of Anesthesiology in the University of Michigan Chronic Pain and Fatigue Research Center (CPFRC) and an Assistant Professor of Obstetrics & Gynecology at Michigan Medicine. He completed his undergraduate work at Cornell College and his doctorate in Psychology at the University of Iowa. His work focuses on the way the immune system influences the central nervous system in chronic pain, using dynamic blood-based markers of immune activity in conjunction with MRI. He is a long-time member of the Biomarker working group in the NIDDK-funded MAPP research network, and a Co-Chair of the Biospecimens working group for the NIAMS-funded BACPAC research collaborative as well as several other HEAL initiative projects.
Qualifications
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Research FellowUniversity of Michigan–Ann Arbor, Ann Arbor, United States
2015 - 2017
Postdoctoral Research
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PhD, Health PsychologyUniversity of Iowa, Iowa City, IA, United States
2010 - 2015
Center Memberships
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Center MemberCaswell Diabetes Institute
Research Overview
• Inflammatory biology of complex medical symptoms
• Post-treatment symptom trajectories in chronic pain
• Immune system influence on the central nervous system
• Quantitative sensory testing in chronic pain
Recent Publications
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Neumann A, Longo J, De EJB, Schrepf A, Kelly AG, McKernan LC. Current Bladder Dysfunction Reports, 2026 Dec 1; 21 (1):Journal ArticlePsychological and Behavioral Contributors to Lower Urinary Tract Dysfunction: Trauma, Stress, and Neurobiological Pathways
DOI:10.1007/s11884-026-00824-x -
Lenert ME, Smith T, Hidalgo-Lopez E, Portengen CM, Harte SE, Beltz AM, Schrepf A, Kaplan CM. Lancet Child and Adolescent Health, 2026 Oct 1; 10 (10): 710 - 718.Journal ArticlePremenarche risk factors for future dysmenorrhoea: a prospective cohort study
DOI:10.1016/S2352-4642(26)00165-3 -
McLain N, Kaplan C, Harte S, Lenert M, Evanski J, Hidalgo-Lopez E, Egan M, Ichesco E, Harris RE, Kutch J, Clauw D, As-Sanie S, Schrepf A. 2026 Sep 30; openRxiv,PreprintFunctional Connectivity Differences Underly Variable Centralized Symptom Relief After Hysterectomy
DOI:10.64898/2026.09.26.754679 -
Lenert ME, Pontari M, Hildago-Lopez E, Clemens JQ, Kaplan CM, Harte SE, Schrepf A. Brain Behav Immun, 2026 Sep 28; 107032Journal ArticleSex-biased toll-like receptor 4 signaling in nociplastic pelvic pain.
DOI:10.1016/j.bbi.2026.107032 PMID: 42805419 -
McLain N, Kaplan C, Harte S, Schrepf A. 2026 Sep 25;PreprintConcordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain.
DOI:10.64898/2026.09.20.753017 PMID: 42818179 -
McLain NJ, Kaplan CM, Naliboff BD, Rodriguez L, Moldwin R, Williams DA, Farrar JT, Harris RE, Spitznagle T, Clauw D, Clemens JQ, Harte SE, Kutch JJ, Schrepf A. Pain, 2026 Sep 29;Journal ArticleDistinct connectivity patterns subserve 2 dimensions of the chronic pain experience
DOI:10.1097/j.pain.0000000000004114 -
Schrepf A, Clauw DJ. Pain, 2026 Aug 27;Journal ArticleTop down vs bottom up nociplastic pain.
DOI:10.1097/j.pain.0000000000004100 PMID: 42708330 -
Hidalgo-Lopez E, Portengen CM, Smith T, Angstadt M, Schrepf A, Clauw DJ, Harte SE, Heitzeg MM, Mindell JA, Beltz AM, Kaplan CM. Communications Biology, 2026 Jul 23;Journal ArticleSex-specific developmental pathways link brain networks, sensory sensitivity, and sleep to adolescent pain
DOI:10.1038/s42003-026-10619-9
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