Research Associate Professor
Pharmacology
Pharmacology
1150 West Medical Center Drive, MSRB3 Rm2200
Ann Arbor, Michigan 48109
[email protected]
1150 West Medical Center Drive, MSRB3 Rm2200
Ann Arbor, Michigan 48109
Available to mentor
Haoming Zhang
Research Associate Professor
Our research is aimed to understand drug metabolism by cytochrome P450 enzymes with focus on their structure function and translational research for development of new therapeutic agents.
https://medschool.umich.edu/profile/2601/haoming-zhang
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberMM-PKUHSC Joint Institute
Drug metabolism and discovery, P450 function and structure, cardiovascular diseases, chaperone Hsp70
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Sun Y, Osawa Y, Zhang H. Arch Biochem Biophys, 2024 Nov 8; 762: 110208Journal ArticleBacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications.
DOI:10.1016/j.abb.2024.110208 PMID: 39522857 -
Sun Y, Martinez-Ramos C, Chen E, Osawa Y, Zhang H. Biomedicines, 2024 Aug 15; 12 (8):Journal ArticleA General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library.
DOI:10.3390/biomedicines12081863 PMID: 39200327 -
Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464Journal ArticleMapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
DOI:10.1016/j.jbc.2023.105464 PMID: 37979917 -
Liu Z, Liu S, Gong Y, Chi X, Wang T, Fan F, Qu C, Lou Y, Zhang L, Zhang B, Yang F, Mohetaboer M, Wang J, Qiu L, Miao L, Lu Y, You R, He P, Li Y, Yi T, Weng H, Xia Y, Wang C, Shi Q, Wang Z, Jiang Y, Li Y, Han C, Wang Y, Wang X, Yang C, Chen YE, Eitzman DT, Zhang H, Li J. Br J Pharmacol, 2024 Oct 4;Journal ArticleThe first in-human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT-678 in acute coronary syndrome patients and healthy volunteers.
DOI:10.1111/bph.17355 PMID: 39367653 -
Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. J Biol Chem, 2023 Aug; 299 (8): 105050Journal ArticleComputational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign.
DOI:10.1016/j.jbc.2023.105050 PMID: 37451479 -
Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Molecules, 2023 Jul 12; 28 (14):Journal ArticleThe Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.
DOI:10.3390/molecules28145353 PMID: 37513226 -
2022 Jun 1;PresentationConformational dynamics of cytochrome P450 enzymes revealed by Cryo-EM
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Bryant AK, Sankar K, Zhao L, Strohbehn GW, Elliott D, Moghanaki D, Kelley MJ, Ramnath N, Green MD, Kenaan C, Shea E, Zhang H, Pratt-Hyatt M, Hollenberg PF. European journal of cancer (Oxford, England : 1990), 2022 Jan 12; 171: 55 - 63.Journal ArticleDe-escalating adjuvant durvalumab treatment duration in stage III non-small cell lung cancer.
