Robert Silbergleit, MD

 Robert Silbergleit
Professor of Emergency Medicine, Medical School
Email:
[email protected]
Available to mentor
Robert Silbergleit, MD
Robert Silbergleit
Professor
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    • About

    Dr. Silbergleit has expertise in organizing and conducting clinical trials in the acute care setting. He has substantial past experience as a translational researcher, working on laboratory animal models of brain injury, and participating in clinical trials in stroke as a site PI and sub-investigator. For the past seven years, he has been a leading co-investigator in the formation and organization of the Neurological Emergencies Treatment Trials network, where he contributed to the oversight and management of all NETT trials. In the NETT he has developed specific expertise and experience in investigating initial interventions in patients with status epilepticus and neurotrauma. In multiple trials, he has developed operational and academic expertise in Exception from Informed Consent (EFIC) for Emergency Research and its conduct under FDA regulations. He is also PI of a just-funded NIH empirical ethics project to study the review of local context by local and central IRB's.

    Center Memberships
    • Center Member
      Institute for Healthcare Policy and Innovation

    Recent Publications

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    • Journal Article
      EEG in patients with altered mental status in the emergency department
      Runcie M, Nolan N, Yoo O, Silbergleit R, Nascimento FA, Kennedy M, Westover MB, Goldstein JN. International Journal of Emergency Medicine, 2026 Dec 1; 19 (1): DOI:10.1186/s12245-026-01200-6
    • Journal Article
      Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest The ICECAP Randomized Clinical Trial
      Meurer WJ, Yeatts SD, Geocadin RG, Roy A, Callaway CW, Ramakrishnan V, Berry SM, Caveney AF, Meyer S, Bozeman N, Harney DM, Speers M, Stevenson VLW, Sozener CB, Daya MR, Beiser DG, Elmer J, Khan IR, Hirsch KG, Kilgannon JH, Nassal M, Johnson NJ, Beekman R, May TL, Brown J, Silbergleit R, Difiore-Sprouse S, Darby J, Doshi A, Drumheller B, Faiver L, Flickinger K, Guyette F, Kaynar A, Molyneaux B, Ratay C, Steinberg A, Tam J, Weissman A, Coppler P, Case N, Strusinska-Thayer M, Le N, Smith J, Cook J, Lupton J, Spurlock W, Kim J, Mouammar M, Neth M, Mcconnell K, Roy S, Sabeh M, Kassir A, Paul J, Molignoni K, Peterson LK, Puri N, Remboski L, Jones C, Kurowsky D, Mchugh D, Stewart R, George B, Banker C, Kamal D, Wood N, Proctor A, Adler D, Acidera J, Fuentes M, Elkort K, Katsandres S, Srinivasan V, Thompson K, Kudenchuk P, Kampp M, Gilmore E, Wira C, Jasak S, Kisken K, Kitlen E, Perman S, D'Onofrio G, Meehl K, Gentile N, Reimer H, Isenberg D, Abboud MT, Gezalian M, Lahiri S, Toosi S, Na SM, Cha J, Obialisi G, Ayodele M, Torbati S, Wilburn J, Buck L, Mazzocco T. JAMA, 2026 Sep 8; 336 (10): 857 - 867. DOI:10.1001/jama.2026.10247
      PMID: 42554995
    • Journal Article
      338 Neuroprognostication Practices in ICECAP, a Large North American Trial Studying Duration of Hypothermic Temperature Control in Patients with Out-of-Hospital Cardiac Arrest
      Schmitzberger F, Roy A, Meurer W, Silbergleit R, Elmer J, May T, Beekman R, Yeatts S, Steinberg A, Khan I, Beiser D, Agarwal S, Kronfeld K, Aufderheide T, Miller B, Paxton J, Wabl R, Jasti J, Hirsch K, Geocadin R. Resuscitation, 2026 Sep 15; 226: s154 - s155. DOI:10.1016/s0300-9572(26)01158-5
    • Additional Scholarship
      Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial (contributions to peer-reviewed journal article not cited with direct authorship; part of SIREN Investigators)
      Meurer WJ, Yeatts SD, Geocadin RG, Roy A, Callaway CW, Ramakrishnan V, Berry SM, Caveney AF, Meyer S, Bozeman N, Harney DM, Speers M, Stevenson VLW, Sozener CB, Daya MR, Beiser DG, Elmer J, Khan IR, Hirsch KG, Kilgannon JH, Nassal M, Johnson NJ, Beekman R, May TL, Brown J, Silbergleit R, SIREN Investigators . JAMA, 2026 Aug 6; DOI:10.1001/jama.2026.10247
    • Journal Article
      Clinicians’ Approaches to Prognostication After Traumatic Brain Injury and Cardiac Arrest: A Multi-Hospital, Qualitative Study
      Steinberg A, Case N, Yang Y, Fischhoff B, Callaway CW, Coppler PJ, Barsan WG, Diaz-Arrastia R, Geocadin R, Okonkwo DO, Shutter L, Silbergleit R, Meurer WJ, Yeatts SD, Elmer J. Neurocritical Care, 2026 Aug 1; 45 (1): 132 - 141. DOI:10.1007/s12028-026-02452-z
      PMID: 41680356
    • Journal Article
      The Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP) Trial (PL5.007)
      Meurer WJ, Silbergleit R, Geocadin R, Yeatts S, Ramakrishnan V. Neurology, 2026 Jun 12; 106 (11_Supplement_1): DOI:10.1212/wnl.0000000000217907
    • Journal Article
      Between-hospital variability in outcomes after cardiac arrest in a large clinical trial network
      Elmer J, Roy A, Silbergleit R, Geocadin RG, Hirsch KG, May TL, Bozeman N, Meyer SB, Beekman R, Nassal MMJ, Ramakrishnan R, Yeatts S, Meurer W. Resuscitation, 2026 Jun 1; 223: DOI:10.1016/j.resuscitation.2026.111090
      PMID: 41974222
    • Presentation
      Critical Applications of Rapid-Response Electroencephalography for the Emergency Department Provider
      Silbergleit R. 2026 Jun 29;

    Featured News & Stories

         hospital bed yellow navy grainy
    Health Lab

    Trial focuses on duration of therapeutic hypothermia for out-of-hospital cardiac arrests

    U-M researchers led the ICECAP trial, the largest U.S. study of therapeutic hypothermia after out-of-hospital cardiac arrest, finding longer cooling offered no benefit.
         Graphic image of a brain with EEG waves across it
    Department News

    Could ketamine be the key to stopping life-threatening seizures?

    Every second counts during a prolonged seizure. Known as status epilepticus, these seizures won’t stop on their own, and if not treated fast, they can lead to brain damage, ICU stays, or death. Michigan Medicine is now leading a major clinical trial that could change how these patients are treated in the emergency department. The study, called KESETT (Ketamine add-on therapy for Established Status Epilepticus Treatment Trial), funded by the NIH, will test whether adding ketamine to current treatments can stop seizures more effectively.
         Signals across a background of the brain
    News Release

    Michigan Medicine launches $31 million national trial to improve emergency seizure care

    Michigan Medicine is leading a major clinical trial that could change how these patients are treated in the emergency department. The study, called KESETT (Ketamine add-on therapy for Established Status Epilepticus Treatment Trial), funded by the National Institutes of Health, will test whether adding ketamine to current treatments can stop seizures more effectively.