Robert Silbergleit, MD
Professor of Emergency Medicine
[email protected]

Available to mentor
Robert Silbergleit, MD
Professor
  • About
  • Center Memberships
  • Recent Publications
    • About

    Dr. Silbergleit has expertise in organizing and conducting clinical trials in the acute care setting. He has substantial past experience as a translational researcher, working on laboratory animal models of brain injury, and participating in clinical trials in stroke as a site PI and sub-investigator. For the past seven years, he has been a leading co-investigator in the formation and organization of the Neurological Emergencies Treatment Trials network, where he contributed to the oversight and management of all NETT trials. In the NETT he has developed specific expertise and experience in investigating initial interventions in patients with status epilepticus and neurotrauma. In multiple trials, he has developed operational and academic expertise in Exception from Informed Consent (EFIC) for Emergency Research and its conduct under FDA regulations. He is also PI of a just-funded NIH empirical ethics project to study the review of local context by local and central IRB's.

    Center Memberships
    • Center Member
      Institute for Healthcare Policy and Innovation
    Recent Publications See All Publications
    • Journal Article
      Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest.
      Meurer WJ, Schmitzberger FF, Yeatts S, Ramakrishnan V, Abella B, Aufderheide T, Barsan W, Benoit J, Berry S, Black J, Bozeman N, Broglio K, Brown J, Brown K, Carlozzi N, Caveney A, Cho S-M, Chung-Esaki H, Clevenger R, Conwit R, Cooper R, Crudo V, Daya M, Harney D, Hsu C, Johnson NJ, Khan I, Khosla S, Kline P, Kratz A, Kudenchuk P, Lewis RJ, Madiyal C, Meyer S, Mosier J, Mouammar M, Neth M, O'Neil B, Paxton J, Perez S, Perman S, Sozener C, Speers M, Spiteri A, Stevenson V, Sunthankar K, Tonna J, Youngquist S, Geocadin R, Silbergleit R, ICECAP trial investigators . Trials, 2024 Jul 23; 25 (1): 502 DOI:10.1186/s13063-024-08280-w
      PMID: 39044295
    • Journal Article
      Variability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial.
      Beekman R, Perman SM, Nguyen C, Kline P, Clevenger R, Yeatts S, Ramakrishnan R, Geocadin RG, Silbergleit R, Meurer WJ, Gilmore EJ. Resuscitation, 2024 Oct; 203: 110397 DOI:10.1016/j.resuscitation.2024.110397
      PMID: 39278393
    • Journal Article
      Improved mortality analysis in early-phase dose-ranging clinical trials for emergency medical diseases using Bayesian time-to-event models with active comparators.
      Shi X, Wick JA, Martin RL, Beall J, Silbergleit R, Rockswold GL, Barsan WG, Korley FK, Rockswold S, Gajewski BJ. Stat Med, 2024 Aug 30; 43 (19): 3649 - 3663. DOI:10.1002/sim.10141
      PMID: 38885949
    • Journal Article
      Clinicians' approach to predicting post-cardiac arrest outcomes for patients enrolled in a United States clinical trial.
      Steinberg A, Yang Y, Fischhoff B, Callaway CW, Coppler P, Geocadin R, Silbergleit R, Meurer WJ, Ramakrishnan R, Yeatts SD, Elmer J. Resuscitation, 2024 Jun; 199: 110226 DOI:10.1016/j.resuscitation.2024.110226
      PMID: 38685376
    • Journal Article
      Continuous EEG Monitoring Practice Variation in TBI: Early Findings in the ELECTRO-BOOST Cohort (S23.009)
      Piotrowski K, Webb A, MacDonald B, Rosenthal E, Gilmore E, Uppal P, Silbergleit R, Diaz-Arrastia R, Kim J, Yeatts S, Ding K. Neurology, 2024 Apr 9; 102 (17_supplement_1): DOI:10.1212/wnl.0000000000204536
    • Presentation
      The Need for Effective Training and Quality Assurance on the NIHTB-CB to Ensure Standardized Administration
      Perez S, Caveney A, Yeatts SD, Kratz AL, Meurer WJ, Silbergleit R, Carlozzi N. 2024 Apr 9;
    • Journal Article
      Monitoring patients with severe traumatic brain injury.
      Diaz-Arrastia R, Bernard F, Shutter L, Barsan W, Silbergleit R. Lancet Neurol, 2024 Mar; 23 (3): 230 - 231. DOI:10.1016/S1474-4422(24)00023-1
      PMID: 38365369
    • Journal Article
      Institutional Review Boards' Assessment of Local Context: A Mixed Methods Study.
      Guetterman TC, Haggins A, Montas S, Black J, Harney D, Fetters MD, Silbergleit R, Dickert NW. Ethics Hum Res, 2024 46 (1): 2 - 13. DOI:10.1002/eahr.500195
      PMID: 38240398