Available to mentor
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Center MemberRogel Cancer Center
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Center MemberPrecision Health Initiative
The Sartor laboratory has both methodological and biomedical areas of focus. Their methodological focus is bioinformatics methods and tools for the analysis of genome-wide regulatory and epigenomics data, and for assessing the biological/clinical significance of results. For instance, Dr. Sartor is a member of the Impact of Genomic Variants on Function (IGVF) NIH Consortium, for which she is developing a coupled tensor-matrix completion method to prioritize disease-specific variant-gene target pairs. The Sartor Lab also focuses on multi-omics approaches for biomarker and treatment-target discovery in disease, focusing specifically on Amyotrophic Lateral Sclerosis (ALS) and head and neck squamous cell carcinomas (HNSCC). Dr. Sartor is PI of an R01 studying downstream consequences of HPV integration in HPV-associated HNSCC, and Co-PI of a Transformative R01 linking environmental exposures with multi-omics in ALS. Being formally trained in biostatistics, Dr. Sartor uses machine learning and statistical approaches to make advances in the above areas.
Sartor Lab
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Banerjee K, Nunez F, Mujeeb A, Mausar A, Tronrud C, Zhu Z, Taher A, Kadiyala P, Carney S, Garcia-Fabiani MB, Comba A, Alghamri M, McClellan B, Faisal S, Nwosu Z, Hong H, Qin T, Sartor M, Ljungman M, Cheng S-Y, Appleman H, Lowenstein P, Lahann J, Lyssiotis C, Castro M. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii316 - viii316.Journal ArticleTMIC-79. IDH1-R132H REWIRES AUTOPHAGY IN THE GLIOMA MICROENVIRONMENT TO FACILITATE TUMOR PROGRESSION AND RESPONSE TO RADIATION
DOI:10.1093/neuonc/noae165.1256 -
Zhao Y, Li X, Wang K, Iyer G, Sakowski SA, Zhao L, Teener S, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Feldman EL, Sartor MA, Goutman SA. EBioMedicine, 2024 Nov; 109: 105383Journal ArticleEpigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis.
DOI:10.1016/j.ebiom.2024.105383 PMID: 39369616 -
Pai S, Qin T, Mattox A, Campbell J, Park JC, Shin K-Y, Sadow P, Faquin W, Haddad R, Pittet M, Garris C, Mempel T, Oneill A, Sartor M. Annals of Oncology, 2024 Sep; 35: s617Journal Article867MO Epigenetic therapy modulates the tumor microenvironment to sensitize anti-PD-1 refractory head and neck cancers to immunotherapy
DOI:10.1016/j.annonc.2024.08.916 -
Li S, Garb BF, Qin T, Soppe S, Lopez E, Patil S, D'Silva NJ, Rozek LS, Sartor MA. 2024 Jul 10;PreprintTumor Subtype Classification Tool for HPV-associated Head and Neck Cancers.
DOI:10.1101/2024.07.05.601906 PMID: 39026719 -
Morgan RK, Wang K, Svoboda LK, Rygiel CA, Lalancette C, Cavalcante R, Bartolomei MS, Prasasya R, Neier K, Perera BPU, Jones TR, Colacino JA, Sartor MA, Dolinoy DC. Environ Health Perspect, 2024 Jun; 132 (6): 67003Journal ArticleEffects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver: A Focus on Genomic Imprinting by Tissue and Sex.
DOI:10.1289/EHP14074 PMID: 38833407 -
Kandarpa M, Robinson D, Wu Y-M, Qin T, Pettit K, Li Q, Luker G, Sartor M, Chinnaiyan A, Talpaz M. Clin Cancer Res, 2024 May 1; 30 (9): 1972 - 1983.Journal ArticleBroad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.
DOI:10.1158/1078-0432.CCR-23-0372 PMID: 38386293 -
Kandarpa M, Robinson D, Wu Y-M, Qin T, Pettit K, Li Q, Luker G, Sartor M, Chinnaiyan A, Talpaz M. 2024 May 1;Additional ScholarshipData from Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations
DOI:10.1158/1078-0432.c.7209134.v1 -
Kandarpa M, Robinson D, Wu Y-M, Qin T, Pettit K, Li Q, Luker G, Sartor M, Chinnaiyan A, Talpaz M. 2024 May 1;Additional ScholarshipData from Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations
DOI:10.1158/1078-0432.c.7209134
