Oren Sagher
Department of Neurosurgery
1500 E. Medical Center Drive, TC3552
Ann Arbor, MI 48109
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About
Dr. Oren Sagher is the William F. Chandler Collegiate Professor of Neurosurgery at the University of Michigan. He has been on faculty at the University since 1993, and is currently Associate Chair for Technological Innovations and Residency Program Director. In the latter role, he is responsible for running a busy neurosurgery residency training program, and mentoring numerous residents, fellows and students. His main clinical interest is in the domain of functional neurosurgery, encompassing the treatment of epilepsy, movement disorders and pain. He serves as the lead epilepsy surgeon at Michigan Medicine, and is interested in brain mapping and advanced imaging techniques in the operating room. Outside the university, Dr. Sagher has held leadership positions in national neurosurgical organizations, with a strong interest in neurosurgical education.
In addition to his work as an academic neurosurgeon, Dr. Sagher also has a strong interest in health-related information technology. In that vein, he created an online neurosurgical portal in 1999, and has continued to develop this platform over the years to a point where it currently informs and drives the care of all neurosurgical patients at the University of Michigan, supplying all providers within the department with timely information needed to optimize the care of their patients. This information system has been extended for use in other services, such as Radiation Oncology and Stroke Neurology.
Qualifications
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ResidencyUniversity of Virginia, Department of Neurosurgery, United States
1988 - 1993
Residency
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Research FellowUniversity of Virginia, Charlottesville, United States
1992 - 1993
Postdoctoral Research
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InternshipUniversity of Virginia, Department of Surgery, United States
1987 - 1988
Internship
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MD1987
Research Overview
Dr. Sagher has a long-standing interest in the regulation of cerebral blood flow, particularly as it relates to neurostimulation. He has led an R01-funded research effort into cerebral blood flow regulation, stroke, and electrical neurostimulation. In addition, he has had an interest in brain tumor imaging, and has been funded by an NIH Quantum grant to study the use of targeted nanoparticles to image brain tumors within the operating room.
Recent Publications
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Tripathy A, Harake ES, Ahmad A, Sharba N, Li A, Saleh S, Sagher O, Heth JA, Altshuler D, Hollon TC, Thompson BG, Pandey AS, Umemura Y, Al-Holou WN. Journal of Neurosurgery, 2026 Oct 1; 145 (4): 1161 - 1173.Journal ArticlePredicting postoperative hospice enrollment following stereotactic brain biopsy: a retrospective study and risk score development
DOI:10.3171/2026.2.JNS251994 PMID: 42537242 -
Cole KL, Van Gompel J, Sagher O, Pham M, Cook S, Cole CD, Spinner RJ, Murad GJ, Couldwell WT, Jensen RL. Journal of the American College of Surgeons, 2026 Jun 1; 242 (6): 1517 - 1528.Journal ArticleThe Scarlet Letter of the Unmatched Neurosurgery Reapplicant: Trends, Opinions, and Guidance from a Nationwide Survey
DOI:10.1097/XCS.0000000000001737 PMID: 41404973 -
Li A, Saleh S, Sharba N, Guivatchian E, Sagher O, Sullivan SE, Heth JA, Hollon TC, Thompson BG, Pandey AS, Umemura Y, Al-Holou WN. Journal of Cancer Research and Clinical Oncology, 2026 Mar 1; 152 (3):Journal ArticleMinimizing the risks of stereotactic brain biopsy in suspected central nervous system lymphoma: a retrospective database study
DOI:10.1007/s00432-026-06458-0 PMID: 41886097 -
Deveney T, Wilseck Z, Trobe J, Sagher O. 2026 Feb 23;Presentation"Neuro-Ophthalmology Grand Rounds" (Grand Rounds; residency interview day)
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Rashidi F, Maleki S, Sabahi M, Habibi MA, Naseri Alavi SA, Arfaie S, Flouty O, Warnke P, Sagher O, Adada B. Epilepsy and Behavior, 2025 Mar 1; 164:Journal ArticleChanges in anxiety after temporal lobe epilepsy surgery: A systematic review and meta-analysis
DOI:10.1016/j.yebeh.2025.110296 PMID: 39923724 -
Scott AJ, Correa LO, Edwards DM, Sun Y, Ravikumar V, Andren AC, Zhang L, Srinivasan S, Jairath N, Verbal K, Muraszko K, Sagher O, Carty SA, Hervey-Jumper S, Orringer D, Kim MM, Junck L, Umemura Y, Leung D, Venneti S, Camelo-Piragua S, Lawrence TS, Ippolito JE, Al-Holou WN, Chinnaiyan P, Heth J, Rao A, Lyssiotis CA, Wahl DR. Antioxidants and Redox Signaling, 2023 Nov 1; 39 (13-15): 942 - 956.Journal ArticleMetabolomic Profiles of Human Glioma Inform Patient Survival
DOI:10.1089/ars.2022.0085 PMID: 36852494 -
Edwards DM, Hopkins A, Scott A, Mannan R, Cao X, Zhang L, Andren A, Heth JA, Muraszko K, Sagher O, Orringer D, Hollon T, Hervey-Jumper S, Venneti S, Camelo-Piragua S, Al-Holou W, Chinnaiyan A, Lyssiotis CA, Wahl DR. International Journal of Radiation Oncology*Biology*Physics, 2024 Aug 9; 117 (2): e101 - e101.Journal ArticleIdentification of Excellent Prognosis IDH Wildtype Glioblastomas Using Genomic and Metabolic Profiling
DOI:10.1016/j.ijrobp.2023.06.870 -
Edwards D, Hopkins A, Scott A, Mannan R, Cao X, Zhang L, Anhren A, Heth J, Muraszko K, Sagher O, Orringer D, Hollon T, Hervey-Jumper S, Venneti S, Camelo-Piragua S, Al-Holou W, Chinnaiyan A, Lyssiotis C, Wahl D. 2023 Oct 12;Proceeding / Abstract / PosterIdentification of Excellent Prognosis IDH Wildtype Glioblastomas Using Genomic and Metabolomic Profiling.
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