Dennis Lyu
Clinical Associate Professor of Internal Medicine
Medical Director
Pulmonology Transplant and MPLAN Co-Director 8D
1500 E. Medical Center Dr., SPC 5244
Ann Arbor
MI, 48109 United States
[email protected]

Available to mentor

Dennis Lyu
Clinical Associate Professor
  • About
  • Recent Publications
  • About

    I am the Medical Director of Lung Transplantation at UM. I oversee all clinical, programmatic, and educational components of the Lung Transplantation Program. I am involved in translational and outcomes research, including NIH-funded multicenter studies. In addition, I am site PI of a clinical trial to study the role of a novel drug in preventing transplant rejection. I have developed curricula for students, residents, fellows, junior attendings, and non-physician learners in the clinical management of pre- and post-lung transplant patients. I chair several monthly interdisciplinary meetings to integrate my program with the great UM Transplant Center including a meeting to select and list transplant candidates, and morbidity and mortality and QI meetings. Based on my international reputation as an expert in the field, I have been invited to serve on multiple committees of the United Network for Organ Sharing (UNOS), which oversees lung transplantation throughout the United States. My role on these committees included developing and approving a new allocation system for prioritization and waitlist rank and lung allocation to reduce deaths on the waitlist, improve access, and mitigate tissue injury.
    From 2019-2021, I served as MPLAN Medical Director of the 8D Medical Surgical Intermediate respiratory unit, During this period, my role ballooned rapidly expanded to include co-managing (with other unit Medical Directors, ACCO, AOD, ACNO, and CMO) the staffing, bed management, and conversion of 6 units to medical ICUs to house up to 250 COVID patients.

    Recent Publications See All Publications
    • Presentation
      Lung Transplant and the Kidney Transplant Safety Net
      Lyu D. 2024 Jun 1;
    • Proceeding / Abstract / Poster
      Evaluation of Use of Tacrolimus vs. Cyclosporine on CLAD Incidence and Allograft Survival in the ISHLT Registry
      Combs MP, Walter K, Hixson H, Belloli EA, Chan KM, Chang AC, Lyu DM. The Journal of Heart and Lung Transplantation, 2024 Apr; 43 (4): s297 - s298. DOI:10.1016/j.healun.2024.02.427
    • Journal Article
      Impact of tacrolimus vs cyclosporine on chronic lung allograft dysfunction incidence and allograft survival in the International Society of Heart and Lung Transplantation registry.
      Combs MP, Walter K, Hixson H, Belloli EA, Najor MS, Chan KM, Chang AC, Lyu DM. J Heart Lung Transplant, 2024 Oct 20; DOI:10.1016/j.healun.2024.10.013
      PMID: 39437867
    • Journal Article
      Lung transplantation for lung cancer: A systematic review of the literature.
      Elsolh B, Bayat Z, Lyu D, Lin J, Wakeam E. J Heart Lung Transplant, 2023 Oct; 42 (10): 1425 - 1436. DOI:10.1016/j.healun.2023.05.011
      PMID: 37253398
    • Presentation
      The Composite Allocation Score (CAS) and Lung Transplant
      2023 Aug 4;
    • Journal Article
      The intersection of race and ethnicity, gender, and primary diagnosis on lung transplantation outcomes.
      Bonner SN, Thumma JR, Valbuena VSM, Stewart JW, Combs M, Lyu D, Chang A, Lin J, Wakeam E. J Heart Lung Transplant, 2023 Jul; 42 (7): 985 - 992. DOI:10.1016/j.healun.2023.02.1496
      PMID: 36967318
    • Additional Scholarship
      UNOS Policy: Establish Continuous Distribution of Lungs
      OPTN Lung Transplantation Committee . 2023 Mar 9;
    • Journal Article
      The mitigating effect of exogenous carbon monoxide on chronic allograft rejection and fibrosis post-lung transplantation.
      Aoki Y, Walker NM, Misumi K, Mimura T, Vittal R, McLinden AP, Fitzgerald L, Combs MP, Lyu D, Osterholzer JJ, Pinsky DJ, Lama VN. J Heart Lung Transplant, 2023 Mar; 42 (3): 317 - 326. DOI:10.1016/j.healun.2022.11.005
      PMID: 36522238