Available to mentor
Dr. Timothy L. Frankel is a faculty member within the Section of General Surgery at the University of Michigan. He graduated Magna Cum Laude from Connecticut College in 2000 with a B.A. in Physics and was elected into Phi Beta Kappa. He earned his medical degree from George Washington University in 2004 and was inducted into the Alpha Omega Alpha Honor Medical Society. He completed a residency in General Surgery at the University of Michigan in 2011 during which time he spent two years at the National Cancer Institute studying tumor immunology and genetic engineering. He developed techniques to genetically modify peripheral blood lymphocytes allowing them to more effectively target tumors for destruction. His work resulted in multiple publications and awards including the James Crudup Surgical Research Award. After completion of residency, he completed a two-year surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York.
Clinical Interests
• His clinical interests are in the treatment of gastrointestinal malignancies including cancers of the liver, pancreas and stomach. He has published multiple clinical papers on techniques in liver resection for colorectal metastases. He is the surgical lead for the liver tumor program at the Ann Arbor VA and has doubled the volume of liver surgery since joining. He is also establishing multidisciplinary cancer clinics to accelerate work-up and treatment of veterans with cancer. He serves as the Chair of the Commission on Cancer certified Cancer Program and was recently named Director of Comprehensive Cancer Care at the Ann Arbor VA. This role is tasked with monitoring the quality of cancer care provided at the institution and shaping policy related to the treatment of cancer patients. He has formed a cancer care navigation program staffed with providers who facilitate care of patients with newly diagnosed or suspicious tumors guiding them through evaluation and treatment.
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FellowMemorial Sloan Kettering Cancer Center, Surgery, 2013
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ResidentUniversity of Michigan Medical School, Surgery, 2011
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Research Fellow, Surgical OncologyNational Cancer Institute, Surgery, 2009
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Center MemberRogel Cancer Center
• Inflammation induced pancreatic cancer
• Understanding spatial relationships of immune cells in the tumor microenvironment
• Understanding the role of adipose derived progenitor cells in promoting pancreatic cancer formation in diabetics
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Krishnan SN, Ji S, Elhossiny AM, Rao A, Frankel TL, Rao A. Comput Biol Med, 2024 Sep 9; 182: 109082Journal ArticleProximogram-A multi-omics network-based framework to capture tissue heterogeneity integrating single-cell omics and spatial profiling.
DOI:10.1016/j.compbiomed.2024.109082 PMID: 39255657 -
Donahue KL, Watkoske HR, Kadiyala P, Du W, Brown K, Scales MK, Elhossiny AM, Espinoza CE, Lasse Opsahl EL, Griffith BD, Wen Y, Sun L, Velez-Delgado A, Renollet NM, Morales J, Nedzesky NM, Baliira RK, Menjivar RE, Medina-Cabrera PI, Rao A, Allen B, Shi J, Frankel TL, Carpenter ES, Bednar F, Zhang Y, Pasca di Magliano M. Cancer Discov, 2024 Oct 4; 14 (10): 1964 - 1989.Journal ArticleOncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth.
DOI:10.1158/2159-8290.CD-24-0100 PMID: 38958646 -
Mills JN, Gunchick V, Mcgue J, Qin Z, Kumar-Sinha C, Bednar F, Brown N, Shi J, Udager AM, Frankel T, Zalupski MM, Sahai V. JNCI Cancer Spectr, 2024 Oct 3;Journal ArticleCharacterization of undifferentiated carcinomas of the pancreas with and without osteoclast-like giant cells.
DOI:10.1093/jncics/pkae097 PMID: 39363498 -
Sun L, Verhaegen ME, McGue J, Olivei AC, Dlugosz AA, Frankel TL, Harms PW. Lab Invest, 2024 Aug 23; 104 (10): 102128Journal ArticleDevelopment of a Multiplex Immunofluorescence Assay for Tumor Microenvironment Studies of Human and Murine Merkel Cell Carcinoma.
DOI:10.1016/j.labinv.2024.102128 PMID: 39182611 -
Elaimy AL, El-Derany MO, James J, Wang Z, Pearson AN, Holcomb EA, Huber AK, Gijón MA, Bell HN, Sanghvi VR, Frankel TL, Su GL, Tapper EB, Tai AW, Ramnath N, Centonze CP, Dobrosotskaya I, Moeller JA, Bryant AK, Elliott DA, Choi E, Evans JR, Cuneo KC, FitzGerald TJ, Wahl DR, Morgan MA, Chang DT, Wicha MS, Lawrence TS, Shah YM, Green MD. JCI Insight, 2024 Sep 17;Journal ArticleSLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma.
DOI:10.1172/jci.insight.184826 PMID: 39287988 -
Elhossiny AM, Okoye J, Williams I, Zhang Y, Watkoske H, Deshpande A, Fertig E, Rao A, Carpenter ES, Frankel TL, Pasca di Magliano M. Cancer Research, 2024 Sep 15; 84 (17_Supplement_2): a046 - a046.Proceeding / Abstract / PosterAbstract A046: Spatial transcriptomics reveals heterogeneity of epithelial and stromal compartments in healthy and tumor pancreas
DOI:10.1158/1538-7445.pancreatic24-a046 -
Kadiyala P, Elhossiny A, Liu J, Bray A, Donahue K, Rao A, Shi J, Zhang Y, Bednar F, Frankel T, Carpenter E, Di Magliano MP. Cancer Research, 2024 Sep 15; 84 (17_Supplement_2): a057 - a057.Proceeding / Abstract / PosterAbstract A057: Investigating Fibroblast-Epithelial crosstalk in pre-malignant and cancerous microenvironment
DOI:10.1158/1538-7445.pancreatic24-a057 -
Henstridge AZ, Kadiyala P, Elhossiny AM, Liu J, Sahai V, Peterson N, Machicado J, Kwon R, Schulman A, Wamsteker E, Philips G, Fernandez-Zapico M, Truty M, Lyssiotis C, Frankel T, Bednar F, Pasca di Magliano M, Carpenter ES. Cancer Research, 2024 Sep 15; 84 (17_Supplement_2): a062 - a062.Proceeding / Abstract / PosterAbstract A062: Neurotropic fibroblast population increases following exposure to chemotherapy in pancreatic adenocarcinoma
DOI:10.1158/1538-7445.pancreatic24-a062
