Lori J Pierce, MD

Lori J. Pierce
Allen S Lichter Distinguished University Professor of Radiation Oncology
Professor of Radiation Oncology
Medical School
Adjunct Professor of Nursing
School of Nursing
University of Michigan
Department of Radiation Oncology
1500 E. Medical Center Dr. Rogel Cancer Center #4308
Ann Arbor, MI 48109
[email protected]
Available to mentor
Lori J Pierce, MD
Lori J. Pierce
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • About

    Dr. Lori Pierce attended Duke University School of Medicine and completed a Radiation Oncology residency and chief residency at the Hospital of the University of Pennsylvania. She then was appointed as a Senior Investigator at the National Cancer Institute, National Institutes of Health in Bethesda, MD from 1990-1992. In 1992, Dr. Pierce joined the faculty of the University of Michigan where she is currently Professor with tenure in Radiation Oncology. Since coming to Michigan, she has served as residency director and clinical director in the Department of Radiation Oncology. In August 2005, Dr. Pierce was appointed by the University of Michigan Board of Regents to be Vice Provost for Academic and Faculty Affairs, a position she still holds.

    Dr. Pierce has dedicated her career to the treatment of breast cancer patients. Her research focuses on the use of radiotherapy in the treatment of breast cancer, with emphasis on cardiac-sparing treatment planning, the use of radiosensitizing agents, and the outcomes of women treated with radiation for breast cancer who are carriers of a BRCA1/2 breast cancer susceptibility gene. She serves as Director of the Michigan Radiation Oncology Quality Consortium (MROQC), a quality consortium of radiation oncology practices across the state of Michigan that seeks to establish best practices in the treatment of breast and lung cancers. She is a previous member of the NCI Breast Cancer Steering Committee and the Steering Committee for the Early Breast Cancer Trialists’ Collaborative Group at the University of Oxford. She continues to serve on many U.S. breast cancer boards and committees and is a member of the Breast Cancer Research Foundation Scientific Advisory Board and the Damon Runyon board.

    Dr. Pierce has published over 260 manuscripts and book chapters and has received numerous awards from the University of Michigan and multiple national organizations. Honors include receipt of the European Society of Therapeutic Radiology and Oncology travel award, the American Medical Association Women Physician Mentor Award, the American Association for Women Radiologists’ Marie Curie Award, the Conquer Cancer Foundation Endowed Women Who Conquer Cancer Mentorship Award, and selection as a Susan G. Komen for the Cure Scholar. Dr. Pierce was elected to the National Academy of Medicine, Class of 2018. She was the recipient of the 2021 Association of Community Cancer Centers Annual Achievement Award and the 2021 American Society for Radiation Oncology Gold Medal Award. In 2022, she received the OncLive Giants of Cancer Care, Community Outreach, Education and Cancer Policy Award. She is the 2023 recipient of the Vivian and Meyer P. Potamkin Foundation Prize for Breast Cancer Research. In 2018, she was elected president of the American Society of Clinical Oncology and served as Chair of the Society Board during 2021-22 and Past President and Chair of the Association Board in 2022-23.

    Qualifications

    • Residency
      University of Pennsylvania Health System, Radiation Oncology, Philadelphia, United States
      1986 - 1988
      Residency
    • Internship
      Thomas Jefferson University Hospital, Internal Medicine, Philadelphia, United States
      1985 - 1986
      Internship

    Center Memberships

    • Center Member
      Institute for Healthcare Policy and Innovation
    • Center Member
      Rogel Cancer Center

    Research Overview

    Breast-conserving therapy for breast cancer
    The effect of radiation in patients with BRCA-1 or BRCA-2 mutations
    The use of intensity modulated radiotherapy in the treatment of breast cancer
    Indications for post-mastectomy radiotherapy
    The use of radiosensitizers in patients with refractory disease

    Recent Publications

    See All Publications
    • Journal Article
      Abstract 6604: Aurora kinase B inhibition enhances radiation response and activates type 1 interferon signaling in triple-negative breast cancer.
      Endraws MA, Jungles KM, Bishop C, Wilson C, Rana PS, Hauk B, Diedrich C, Markovic V, Hochmuth E, McBean BN, Liu M, Pierce L, Rae JM, Speers CW. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6604 - 6604. DOI:10.1158/1538-7445.am2026-6604
    • Journal Article
      Population-level trends in radiation treatment of low-risk prostate cancer.
      Odayar V, Monda S, Yin H, Tucker Gonzalez R, Casas SJ, Hopfensperger K, Kendrick D, Mietzel MA, Mislmani M, Zaki MA, McLaughlin PW, Morgan TM, Jackson WC, Schipper MJ, Heimburger DK, Bryant AK, Pierce LJ, Borza T, Dess RT. Journal of Clinical Oncology, 2026 Mar 4; 44 (7_suppl): 336 - 336. DOI:10.1200/jco.2026.44.7_suppl.336
    • Journal Article
      Transcriptomic analysis to uncover the mechanism of radiosensitization of AR-positive triple-negative breast cancers with AR inhibition.
      McBean B, Hauk B, Michmerhuizen AR, Chandler BC, Pesch AM, Lerner LM, Gurdak D, Ward C, Rana P, Zeidane RA, Mercer V, Tao M, Hochmuth E, Jungles KM, The S, Liu M, Spratt DE, Boyle AP, Pierce LJ, Speers CW. NPJ Breast Cancer, 2026 Feb 24; DOI:10.1038/s41523-026-00916-1
      PMID: 41735341
    • Journal Article
      Barriers to the Adoption of Healthy Lifestyle Behaviors in Patients With Cancer: Results of a National Survey.
      Wilson RL, Giobbie-Hurder A, Bender CM, Brewster AM, Crane TE, Hopkins JO, Masters GA, Pierce LJ, Ligibel JA, Dieli-Conwright CM. JCO Oncol Pract, 2026 Feb 17; OP2501029 DOI:10.1200/OP-25-01029
      PMID: 41701954
    • Journal Article
      Impact of Tamoxifen Only After Lumpectomy for “Good-Risk” Duct Carcinoma In Situ: Combined Analysis of the NRG Oncology/RTOG 9804 and ECOG-ACRIN E5194 Trials
      Wright JL, Moughan J, Woodward WA, Rahbar H, Shah AB, Comstock C, Jarvis LA, Tjoe JA, Germain I, Badve SS, Strom E, Recht A, Ling DC, Vallow LA, Stephenson JJ, Currey A, Walker EM, Reiter H, Steinberg ML, Pierce LJ, Winter K, Sparano J, Davidson NE, Wolff A, Mamounas EP, White JR, McCormick B. International Journal of Radiation Oncology Biology Physics, 2026 Jan 1; DOI:10.1016/j.ijrobp.2026.04.103
      PMID: 42114785
    • Journal Article
      Associations between social drivers of health and breast cancer stage at diagnosis among U.S. Black women
      Barnard ME, Qin B, Emerson MA, Holder EX, Dunn MR, Sarkar S, Xu NN, Li Y, Ambrosone CB, Bandera EV, Palmer JR, Troester MA, Hyslop T, Norton L, Garber JE, El-Ashry D, Malhotra P, Pearce CL, Gomez S, Bower JE, Perou CM, Newman LA, Hershman DL, Davis MB, Carey LA, Pierce LJ. Npj Breast Cancer, 2025 Dec 1; 11 (1): DOI:10.1038/s41523-025-00804-0
    • Journal Article
      Augmenting Type 1 interferon antitumoral immune signaling in triple-negative breast cancer (TNBC) via combined radiotherapy and monopolar spindle kinase I (Mps1) inhibition 3799
      Jungles KM, Bishop C, Wilson C, Liu M, Speers C, Pierce L, Rae J. The Journal of Immunology, 2025 Nov 23; 214 (Supplement_1): DOI:10.1093/jimmun/vkaf283.1559
    • Proceeding / Abstract / Poster
      Acute Toxicity in SWOG 1706, a Randomized Trial Comparing Radiotherapy for Inflammatory Breast Cancer with and without Concurrent Olaparib
      Jagsi R, Meisner A, Chalasani P, Barlow W, Bellon JR, Henry NL, Lew D, Matuszak MM, Moran JM, Pierce LJ, Rakovitch E, Reyes S, Speers C, Unger J, White JR, Woodward WA, Zellars RC, Pusztai L, Sharma P. International Journal of Radiation Oncology • Biology • Physics, 2025 Sep 28; 123 (1): s113 - s114. DOI:10.1016/j.ijrobp.2025.06.1169

    Featured News & Stories

    Lori J. Pierce, M.D.
    Medical School News

    Medical School’s Lori J. Pierce, MD, named Distinguished University Professor

    Medical School professor Lori J. Pierce, M.D., is one of six U-M faculty members recognized for their outstanding teaching and service with one of the university’s most prestigious honors: the Distinguished University Professorship. Each professorship bears a name determined by the appointed professor in consultation with their dean. Pierce is the Allen S. Lichter Distinguished University Professor of Radiation Oncology.
    David and Linda Bachrach smile as they stand together outside.
    Philanthropy News

    Philanthropy in action: donors promote scholarship and leadership through intentional giving

    Through philanthropy, David and Linda Bachrach are empowering women in leadership roles and supporting U-M scholarships and awards.
    Lori L. Isom, Ph.D., Sally A. Camper, Ph.D., Karin Muraszko, M.D., Lori J. Pierce, M.D., Dee E. Fenner, M.D.
    Medical School News

    Communication, ‘rethinking our system’ are keys to future of biomedical science

    If biomedical science is to survive, researchers must communicate better about the discoveries and promise of science and medicine, as well as their complexities and limits, and the critical importance of both in serving the public good. Such communication is necessary in times of crisis, like now, according to Huda Akil, Ph.D., one of the Medical School’s top biomedical researchers, both in longevity (47 years at the U-M) and success (2023 recipient of the National Medal of Science). She delivered the keynote address at the third annual Celebration of Women in Academic Medicine and Science on Feb. 5.
    Sally A. Camper, Ph.D., and Lori J. Pierce, M.D.
    Medical School News

    Sally A. Camper, Ph.D., and Lori J. Pierce, M.D., to receive Muraszko Award

    Two Medical School leaders are being honored for their efforts to help women forge successful careers in academic medicine and science. Sally A. Camper, Ph.D., and Lori J. Pierce, M.D., will receive the Karin Muraszko, M.D., Advancing Women in Academic Medicine and Science Award on Feb. 5 at the third annual Celebration of Women in Academic Medicine and Science.