Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research
Professor, Computational Medicine and Bioinformatics
[email protected]

Available to mentor
Matthias Kretzler, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
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    Qualifications
    • PhD
      University of Heidelberg, 1993
    • MD
      University of Heidelberg, 1992
    • Baccalaureate
      St. Paulusheim, 1985
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      MExperts-Center for Global Health Equity
    • Center Member
      Global REACH
    • Center Member
      Precision Health Initiative
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks

    Integrative systems biology of renal disease with a focus on glomerular diseases

    Molecular diagnostic and target identification of renal disease

    Links
    • MiKTMC
    Recent Publications See All Publications
    • Journal Article
      Risk Factors for Disease Progression for Adults and Children With Membranous Nephropathy in the Cure Glomerulonephropathy Network (CureGN)
      Laurin LP, Helmuth M, Almaani S, Ayoub I, Chen DP, Villegas LA, Nast CC, Robinson BM, Derebail VK, Waldman M, Bomback AS. Kidney International Reports, 2025 Jun 1; 10 (6): 1917 - 1928. DOI:10.1016/j.ekir.2025.03.027
    • Journal Article
      Loss of genome maintenance is linked to mTORC1 signaling and accelerates podocyte damage.
      Braun F, Mandel AM, Blomberg L, Wong MN, Chatzinikolaou G, Meyer DH, Reinelt A, Nair V, Akbar-Haase R, McCown PJ, Haas F, Chen H, Rahmatollahi M, Fermin D, Ebbestad R, Slaats GG, Bork T, Schell C, Koehler S, Brinkkoetter PT, Lindenmeyer MT, Cohen CD, Kann M, Unnersjö-Jess D, Bloch W, Sampson MG, Dollé ME, Puelles VG, Kretzler M, Garinis GA, Huber TB, Schermer B, Benzing T, Schumacher B, Kurschat CE. JCI Insight, 2025 May 20; DOI:10.1172/jci.insight.172370
      PMID: 40392611
    • Journal Article
      The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure.
      Cusick M, Nair V, Fermin D, Hartman J, Beamish JA, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon MC, Kretzler M, Wiggins RC, Naik AS. JCI Insight, 2025 May 6; DOI:10.1172/jci.insight.188485
      PMID: 40327402
    • Journal Article
      Alternative splicing of uromodulin enhances mitochondrial metabolism for adaptation to stress in kidney epithelial cells.
      Nanamatsu A, Rhodes GJ, LaFavers KA, Micanovic R, Lazar V, Khan S, Barwinska D, Makino S, Zollman A, Cheng Y-H, Doud EH, Mosley AL, Repass MJ, Kamocka MM, Baride A, Phillips CL, Kelly KJ, Eadon MT, Himmelfarb J, Kretzler M, Bacallao RL, Dagher PC, Hato T, El-Achkar TM. J Clin Invest, 2025 Apr 8; DOI:10.1172/JCI183343
      PMID: 40198127
    • Journal Article
      Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study.
      Glenn DA, Andrews C, Liu Q, Zee J, Mansfield S, Smith A, O'Shaughnessy MM, Bomback A, Gibson K, Greenbaum LA, Falk RJ, Hogan SL, Mottl A, Denburg MR, CureGN Consortium . Am J Kidney Dis, 2025 Apr; 85 (4): 528 - 531. DOI:10.1053/j.ajkd.2024.10.008
      PMID: PMC11952743
    • Preprint
      Not all controls are made equal: Definition of human kidney reference samples by single cell gene expression profiles.
      Menon R, Kimmel PL, Otto EA, Subramanian L, Berthier CC, O' Connor CL, Godfrey B, Naik AS, Sarwal M, Woodle ES, Pyle L, Choi YJ, Ladd P, Sedor JR, Rosas SE, Waikar SS, Bitzer M, Bjornstad P, Hodgin JB, Kretzler M, Kidney Precision Medicine Project (KPMP) . 2025 Mar 25; DOI:10.1101/2025.03.17.25324134
      PMID: 40166576
    • Journal Article
      Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.
      Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E, Hancock B, Dominguez ST, Gurra MG, Gurajala S, Jonsson AH, Seifert JA, Feser ML, Norris JM, Cao Y, Apruzzese W, Bridges SL, Bykerk VP, Goodman S, Donlin LT, Firestein GS, Bathon JM, Hughes LB, Filer A, Pitzalis C, Anolik JH, Moreland L, Hacohen N, Guthridge JM, James JA, Cuda CM, Perlman H, Brenner MB, Raychaudhuri S, Sparks JA, Accelerating Medicines Partnership RA/SLE Network , Holers VM, Deane KD, Lederer J, Rao DA, Zhang F. J Clin Invest, 2025 Mar 17; 135 (6): DOI:10.1172/JCI185217
      PMID: PMC11910230
    • Journal Article
      Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases.
      Alakwaa F, Das V, Majumdar A, Nair V, Fermin D, Dey AB, Slidel T, Reilly DF, Myshkin E, Duffin KL, Chen Y, Bitzer M, Pennathur S, Brosius FC, Kretzler M, Ju W, Karihaloo A, Eddy S. JCI Insight, 2025 Mar 10; 10 (5): DOI:10.1172/jci.insight.186070
      PMID: PMC11949029