Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
[email protected]
Available to mentor
Matthias Kretzler, MD
Professor
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PhDUniversity of Heidelberg, Heidelberg, 1993
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MDUniversity of Heidelberg, Heidelberg, 1992
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BaccalaureateSt. Paulusheim, Bruchsal, 1985
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Center MemberBiosciences Initiative
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Center MemberPrecision Health Initiative
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberCaswell Diabetes Institute
Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
Integrative systems biology of renal disease with a focus on glomerular diseases
Molecular diagnostic and target identification of renal disease
MiKTMC
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Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, Robley C, Anglicheau D, Rabant M, Sannier A, Timsit M-O, Eddy S, Kretzler M, Ju W, Mechta-Grigoriou F. Nat Commun, 2024 Jan 25; 15 (1): 743Journal ArticleWNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
DOI:10.1038/s41467-024-44886-z PMID: 38272907 -
Heerspink HJL, Kretzler M. Journal of the American Society of Nephrology, 2024 Aug 1; 35 (8): 1123 - 1126.Journal ArticleClinical Trials for Kidney Disease in the Era of Personalized Medicine
DOI:10.1681/ASN.0000000000000412 -
Troost JP, D'Souza J, Buxton M, Kshirsagar AV, Engel LS, O'Lenick CR, Smoyer WE, Klein J, Ju W, Eddy S, Helmuth M, Mariani LH, Kretzler M, Trachtman H. Kidney Int Rep, 2024 Aug; 9 (8): 2527 - 2536.Journal ArticleElevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.
DOI:10.1016/j.ekir.2024.05.013 PMID: 39156153 -
Yoon J, Liu Z, Alaba M, Bruggeman LA, Janmey P, Arana C, Ayenuyo O, Medeiros I, Nair V, Eddy S, Kretzler M, Henderson JM, Naik A, Chang AN, Miller RT. 2024 Jul 5;PreprintGlomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy.
DOI:10.1101/2024.02.26.582201 PMID: 38948788 -
Juliar BA, Stanaway IB, Sano F, Fu H, Smith KD, Akilesh S, Scales SJ, El Saghir J, Bhatraju PK, Liu E, Yang J, Lin J, Eddy S, Kretzler M, Zheng Y, Himmelfarb J, Harder JL, Freedman BS. Cell Rep, 2024 Jun 25; 43 (6): 114310Journal ArticleInterferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease.
DOI:10.1016/j.celrep.2024.114310 PMID: 38838223 -
Subramanian A, Vernon KA, Zhou Y, Marshall JL, Alimova M, Arevalo C, Zhang F, Slyper M, Waldman J, Montesinos MS, Dionne D, Nguyen LT, Cuoco MS, Dubinsky D, Purnell J, Keller K, Sturner SH, Grinkevich E, Ghoshal A, Kotek A, Trivioli G, Richoz N, Humphrey MB, Darby IG, Miller SJ, Xu Y, Weins A, Chloe-Villani A, Chang SL, Kretzler M, Rosenblatt-Rosen O, Shaw JL, Zimmerman KA, Clatworthy MR, Regev A, Greka A. Cell Rep, 2024 Jun 25; 43 (6): 114253Journal ArticleProtective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury.
DOI:10.1016/j.celrep.2024.114253 PMID: 38781074 -
Gyarmati G, Shroff UN, Riquier-Brison A, Desposito D, Ju W, Stocker SD, Izuhara A, Deepak S, Becerra Calderon A, Burford JL, Kadoya H, Moon J-Y, Chen Y, Rinschen MM, Ahmadi N, Lau L, Biemesderfer D, James AW, Minichiello L, Zlokovic BV, Gill IS, Kretzler M, Peti-Peterdi J. J Clin Invest, 2024 Apr 10; 134 (11):Journal ArticleNeuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.
DOI:10.1172/JCI174558 PMID: 38598837 -
Reznichenko A, Nair V, Eddy S, Fermin D, Tomilo M, Slidel T, Ju W, Henry I, Badal SS, Wesley JD, Liles JT, Moosmang S, Williams JM, Quinn CM, Bitzer M, Hodgin JB, Barisoni L, Karihaloo A, Breyer MD, Duffin KL, Patel UD, Magnone MC, Bhat R, Kretzler M. Kidney Int, 2024 Jun; 105 (6): 1263 - 1278.Journal ArticleUnbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine.
DOI:10.1016/j.kint.2024.01.012 PMID: 38286178
