Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research
Professor
Computational Medicine and Bioinformatics
[email protected]

Available to mentor
Matthias Kretzler, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • PhD
      University of Heidelberg, Heidelberg, 1993
    • MD
      University of Heidelberg, Heidelberg, 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, 1985
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Global REACH
    • Center Member
      Precision Health Initiative
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks

    Integrative systems biology of renal disease with a focus on glomerular diseases

    Molecular diagnostic and target identification of renal disease

    Links
    • MiKTMC
    Recent Publications See All Publications
    • Journal Article
      Perioperative Acute Kidney Injury: Diagnosis, Prediction, Prevention, and Treatment.
      Douville NJ, Mathis M, Kheterpal S, Heung M, Schaub J, Naik A, Kretzler M. Anesthesiology, 2025 Jan 1; 142 (1): 180 - 201. DOI:10.1097/ALN.0000000000005215
      PMID: 39527650
    • Journal Article
      Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.
      Choi YJ, Richard G, Zhang G, Hodgin JB, Demeke DS, Yang Y, Schaub JA, Tamayo IM, Gurung BK, Naik AS, Nair V, Birznieks C, MacDonald A, Narongkiatikhun P, Gross S, Driscoll L, Flynn M, Tommerdahl K, Nadeau KJ, Shah VN, Vigers T, Snell-Bergeon JK, Kendrick J, van Raalte DH, Li L-P, Prasad P, Ladd P, Chin BB, Cherney DZ, McCown PJ, Alakwaa F, Otto EA, Brosius FC, Saulnier PJ, Puelles VG, Goodrich JA, Street K, Venkatachalam MA, Ruiz A, de Boer IH, Nelson RG, Pyle L, Blondin DP, Sharma K, Kretzler M, Bjornstad P. J Clin Invest, 2024 Oct 22; 134 (24): DOI:10.1172/JCI183984
      PMID: 39436695
    • Preprint
      Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy.
      Yoon J, Liu Z, Alaba M, Bruggeman LA, Janmey PA, Arana CA, Ayenuyo O, Medeiros I, Eddy S, Kretzler M, Henderson JM, Nair V, Naik AS, Chang AN, Miller RT. 2024 Dec 9; DOI:10.1101/2024.02.26.582201
      PMID: 38948788
    • Journal Article
      Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
      Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Dec; 149: 103296 DOI:10.1016/j.jaut.2024.103296
      PMID: 39241536
    • Journal Article
      Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
      Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM, BEAt-DKD consortium . Nat Commun, 2024 Nov 19; 15 (1): 10018 DOI:10.1038/s41467-024-54089-1
      PMID: 39562547
    • Journal Article
      Proteomic Analysis Uncovers Multiprotein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus.
      Pyle L, Choi YJ, Narongkiatikhun P, Sharma K, Waikar S, Layton A, Tommerdahl KL, de Boer I, Vigers T, Nelson RG, Lynch J, Brosius F, Saulnier PJ, Goodrich JA, Tryggestad JB, Isganaitis E, Bacha F, Nadeau KJ, van Raalte D, Kretzler M, Heerspink H, Bjornstad P. Clin J Am Soc Nephrol, 2024 Dec 1; 19 (12): 1603 - 1612. DOI:10.2215/CJN.0000000000000559
      PMID: 39432369
    • Journal Article
      WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
      Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, Robley C, Anglicheau D, Rabant M, Sannier A, Timsit M-O, Eddy S, Kretzler M, Ju W, Mechta-Grigoriou F. Nat Commun, 2024 Jan 25; 15 (1): 743 DOI:10.1038/s41467-024-44886-z
      PMID: 38272907
    • Preprint
      Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest APOL1 Risk Variants Impact Parietal Epithelial Cells
      Gonzalez-Vicente A, Crawford DC, Bush WS, Wu Z, Bruggeman LA, Nair V, Eichinger F, Wessely O, Kretzler M, O’Toole JF, Sedor JR, Project KPM, Network NSS. medRxiv, DOI:10.1101/2024.11.05.24316766