Matthias Kretzler, MD

Kretzler
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
Medical School
Email:
[email protected]
Available to mentor
Matthias Kretzler, MD
Kretzler
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
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  • Qualifications

    • PhD
      University of Heidelberg, Heidelberg, Germany
      1992 - 1993
    • MD
      University of Heidelberg, Heidelberg, Germany
      1985 - 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, Germany
      1976 - 1985

    Center Memberships

    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Global Health Equity
    • Center Member
      Global REACH
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    - Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
    - Integrative systems biology of renal disease with a focus on glomerular diseases
    - Molecular diagnostic and target identification of renal disease

    Links

    • MiKTMC

    Recent Publications

    See All Publications
    • Journal Article
      Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition
      Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduction and Targeted Therapy, 2026 Dec 1; 11 (1): DOI:10.1038/s41392-026-02653-0
      PMID: 42009641
    • Journal Article
      Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
      Acera-Mateos M, Adiconis X, Li JK, Marchese D, Caratù G, Hon CC, Tiwari P, Kojima M, Vieth B, Murphy MA, Simmons SK, Lefevre T, Claes I, O’Connor CL, Menon R, Otto EA, Ando Y, Vandereyken K, Kretzler M, Bitzer M, Fraenkel E, Voet T, Enard W, Carninci P, Heyn H, Levin JZ, Mereu E. Genome Biology, 2026 Dec 1; 27 (1): DOI:10.1186/s13059-026-04002-4
      PMID: 41821037
    • Journal Article
      Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial
      Ju W, Nair V, Vart P, Smeijer JD, Hudkins KL, Moedt E, Larkina M, Perco P, Burdet F, Shedden K, Hwang M, Lee E, O’Connor C, Hartman J, Subramanian L, Bitzer M, Ibberson M, Duffin KL, Gomez MF, Alpers CE, Kretzler M, Heerspink HJL. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-68973-5
      PMID: 41654492
    • Journal Article
      Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project
      Schaub JA, Menon R, Melo Ferreira R, Kiernan E, Schmidt IM, Limonte CP, Yennapureddy S, Cheng Y-H, Herlitz L, Rosenberg AZ, Henderson JM, Smith KD, Hodgin JB, Otto E, Moeckel GW, Cantley LG, Setty S, Balis UGJ, Demeke D, Fogo AB, Bomback AS, D’Agati VD, Stillman IE, Torrealba JR, Hendricks AR, Bracamonte E, Moreno V, Bhatraju P, Mottl AK, Brosius FC, Thajudeen B, Coca SG, Palevsky PM, Randhawa PS, Murugan R, Barisoni L, Alpers CE, Menez S, Wilson FP, Moledina DG, Eadon MT, Kretzler M, Himmelfarb J, Parikh CR. JCI Insight, 2026 Aug 12; 11 (15): DOI:10.1172/jci.insight.204127
    • Journal Article
      Individualised treatment effects of corticosteroids in IgA nephropathy
      Hölscher DL, Schmitz NEJ, Niggemeier L, Pilva P, Strauch M, Tesar V, Barratt J, Roberts ISD, Coppo R, Barisoni L, Yanagita M, Alabalik U, Rule AD, Jagtap JM, Abreu ES, Seikrit C, von Stillfried S, Taal MW, Kalra PA, Floege J, Kramann R, Boor P, Bülow RD, Russo ML, Troyanov S, Cook HT, Roberts ISD, Tesar V, Maixnerova D, Lundberg S, Gesualdo L, Emma F, Diomedi F, Beltrame G, Rollino C, Amore A, Camilla R, Peruzzi L, Praga M, Feriozzi S, Polci R, Segoloni G, Colla L, Pani A, Piras D, Angioi A, Cancarini G, Ravera S, Durlik M, Moggia E, Ballarin J, Di Giulio S, Pugliese F, Serriello I, Caliskan Y, Sever M, Kilicaslan I, Locatelli F, Del Vecchio L, Wetzels JFM, Peters H, Berg U, Carvalho F, da Costa Ferreira AC, Maggio M, Wiecek A, Ots-Rosenberg M, Magistroni R, Topaloglu R, Bilginer Y, D’Amico M, Stangou M, Giacchino F, Goumenos D, Kalliakmani P, Papasotiriou M, Galesic K, Geddes C, Siamopoulos K, Balafa O, Galliani M, Stratta P, Quaglia M, Bergia R, Cravero R, Salvadori M, Cirami L, Fellstrom B, Kloster Smerud H, Ferrario F, Stellato T, Egido J, Martin C, Floege J, Eitner F, Lupo A, Bernich P, Menè P, Morosetti M, van Kooten C. Ebiomedicine, 2026 Aug 1; 130: DOI:10.1016/j.ebiom.2026.106396
      PMID: 42447753
    • Journal Article
      Not all reference samples are equal in single-cell transcriptomics of human kidney tissue
      Menon R, Kimmel PL, Otto EA, Subramanian L, O'Connor CL, Godfrey B, Smith C, Alakwaa F, Berthier CC, Sarwal MM, Woodle ES, Pyle L, Choi YJ, Ladd P, Sedor JR, Rosas SE, Waikar SS, Naik AS, Melo Ferreira R, Eadon MT, Bitzer M, Bjornstad P, Hodgin JB, Kretzler M, Kpmp FTKPMP. Jci Insight, 2026 Jul 22; 11 (14): DOI:10.1172/jci.insight.204385
      PMID: 42160485
    • Journal Article
      SGLT2 inhibition modulates metabolic, vascular, and inflammatory molecular markers in the kidney in youth with type 1 diabetes
      Bjornstad P, Choi YJ, Narongkiatikhun P, Karihaloo A, Prasad PV, Li LP, Tommerdahl KL, Sethi M, Ramesh S, Birznieks C, Clarke A, Elia Y, Curtis J, Clarson C, Weissenkampen D, D’antonio M, Pinzon Cortes JA, Hampson H, Yuan L, van Eeghen SA, Kanter JE, Bornfeldt KE, Vaisar T, Ladd P, Heerspink HJL, de Boer IH, Goodrich JA, Street K, Tuttle KR, Bergmann KR, Smith C, Hodgin JB, Schaub JA, Nair V, Menon R, Naik AS, Mccown PJ, Alakwaa F, Eddy S, Otto E, Kim NH, Nelson RG, Puelles VG, van Raalte DH, Cherney DZI, Pyle L, Mahmud FH, Kretzler M. Science Translational Medicine, 2026 Jul 22; 18 (859): DOI:10.1126/scitranslmed.aee1005
    • Preprint
      Atlas of glomerular disease-specific genetic effects on blood transcriptome.
      Liu L, Wang C, Kravets O, Fermin D, Eichinger F, Zanoni F, Khan A, Zhang JY, Ouyang Y, Li Q, Hamilton P, Kalra PA, Chinnadurai R, Reidy K, Kopp J, Mucha K, Smith C, Smith AR, Mcnulty M, Eddy S, Nair V, Helmuth ME, Vasylyeva TL, Smoyer WE, Berthier C, Parekh R, Wenderfer SE, Onugha E, Martin T, Sokolova K, Sealfon RSG, Theesfeld CL, Parsa A, Gbadegesin R, Sampson M, Sanna-Cherchi S, Troyanskaya OG, Paul DS, Petrovski S, Goldstein D, Mariani LH, Gharavi A, Columbia Genomics Consortium, NEPTUNE Consortium, CureGN Consortium , Kretzler M, Kiryluk K. 2026 Jul 20; DOI:10.64898/2026.06.22.26356281
      PMID: 42396300

    Featured News & Stories

    Kretzler
    Department News

    Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award

    Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
    Dr. Kretzler and lab member looking at a sample in the lab
    Great Minds, Greater Discoveries Stories

    Matthias Kretzler, MD: Studying the onset and progression of kidney diseases

    Learn more about the innovative work of research investigators at the University of Michigan Medical School.
    Rare Kidney Disease
    Department News

    University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day

    Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
    kidneys blue yellow
    Health Lab

    New technology called PathoPlex maps the location of proteins inside cells

    Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.