Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research
Professor of Computational Medicine and Bioinformatics
[email protected]

Available to mentor
Matthias Kretzler, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • PhD
      University of Heidelberg, Heidelberg, 1993
    • MD
      University of Heidelberg, Heidelberg, 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, 1985
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Precision Health Initiative
    • Center Member
      Global REACH
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks

    Integrative systems biology of renal disease with a focus on glomerular diseases

    Molecular diagnostic and target identification of renal disease

    Links
    • MiKTMC
    Recent Publications See All Publications
    • Journal Article
      Perioperative Acute Kidney Injury: Diagnosis, Prediction, Prevention, and Treatment.
      Douville NJ, Mathis M, Kheterpal S, Heung M, Schaub J, Naik A, Kretzler M. Anesthesiology, 2025 Jan 1; 142 (1): 180 - 201. DOI:10.1097/ALN.0000000000005215
      PMID: 39527650
    • Journal Article
      Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
      Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Sep 5; 149: 103296 DOI:10.1016/j.jaut.2024.103296
      PMID: 39241536
    • Journal Article
      Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
      Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM, BEAt-DKD consortium . Nat Commun, 2024 Nov 19; 15 (1): 10018 DOI:10.1038/s41467-024-54089-1
      PMID: 39562547
    • Journal Article
      WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
      Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, Robley C, Anglicheau D, Rabant M, Sannier A, Timsit M-O, Eddy S, Kretzler M, Ju W, Mechta-Grigoriou F. Nat Commun, 2024 Jan 25; 15 (1): 743 DOI:10.1038/s41467-024-44886-z
      PMID: 38272907
    • Preprint
      Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy.
      Yoon J, Liu Z, Alaba M, Bruggeman LA, Janmey PA, Arana CA, Ayenuyo O, Medeiros I, Eddy S, Kretzler M, Henderson JM, Nair V, Naik AS, Chang AN, Miller RT. 2024 Nov 17; DOI:10.1101/2024.02.26.582201
      PMID: 38948788
    • Journal Article
      Association of urinary EGF, FABP3, and VCAM1 levels with the progression of early diabetic kidney disease.
      Keller F, Denicolò S, Leierer J, Kruus M, Heinzel A, Kammer M, Ju W, Nair V, Burdet F, Ibberson M, Menon R, Otto E, Choi YJ, Pyle L, Ladd P, Bjornstad PM, Eder S, Rosivall L, Mark PB, Wiecek A, Heerspink HJL, Kretzler M, Oberbauer R, Mayer G, Perco P. Kidney Blood Press Res, 2024 Nov 7; 1 - 21. DOI:10.1159/000542267
      PMID: 39510044
    • Preprint
      Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest APOL1 Risk Variants Impact Parietal Epithelial Cells
      Gonzalez-Vicente A, Crawford DC, Bush WS, Wu Z, Bruggeman LA, Nair V, Eichinger F, Wessely O, Kretzler M, O’Toole JF, Sedor JR, Project KPM, Network NSS. medRxiv, DOI:10.1101/2024.11.05.24316766
    • Journal Article
      Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response.
      Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network , Guthridge JM, Petri M, Buyon J, James JA. Arthritis Rheumatol, 2024 Nov; 76 (11): 1611 - 1622. DOI:10.1002/art.42941
      PMID: 38962936