Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research
Professor
Computational Medicine and Bioinformatics
[email protected]
Available to mentor
Matthias Kretzler, MD
Professor
-
PhDUniversity of Heidelberg, Heidelberg, 1993
-
MDUniversity of Heidelberg, Heidelberg, 1992
-
BaccalaureateSt. Paulusheim, Bruchsal, 1985
-
Center MemberBiosciences Initiative
-
Center MemberGlobal REACH
-
Center MemberPrecision Health Initiative
-
Center MemberMM-PKUHSC Joint Institute
-
Center MemberCenter for Computational Medicine and Bioinformatics
-
Center MemberCaswell Diabetes Institute
Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
Integrative systems biology of renal disease with a focus on glomerular diseases
Molecular diagnostic and target identification of renal disease
MiKTMC
-
Douville NJ, Mathis M, Kheterpal S, Heung M, Schaub J, Naik A, Kretzler M. Anesthesiology, 2025 Jan 1; 142 (1): 180 - 201.Journal ArticlePerioperative Acute Kidney Injury: Diagnosis, Prediction, Prevention, and Treatment.
DOI:10.1097/ALN.0000000000005215 PMID: 39527650 -
Choi YJ, Richard G, Zhang G, Hodgin JB, Demeke DS, Yang Y, Schaub JA, Tamayo IM, Gurung BK, Naik AS, Nair V, Birznieks C, MacDonald A, Narongkiatikhun P, Gross S, Driscoll L, Flynn M, Tommerdahl K, Nadeau KJ, Shah VN, Vigers T, Snell-Bergeon JK, Kendrick J, van Raalte DH, Li L-P, Prasad P, Ladd P, Chin BB, Cherney DZ, McCown PJ, Alakwaa F, Otto EA, Brosius FC, Saulnier PJ, Puelles VG, Goodrich JA, Street K, Venkatachalam MA, Ruiz A, de Boer IH, Nelson RG, Pyle L, Blondin DP, Sharma K, Kretzler M, Bjornstad P. J Clin Invest, 2024 Oct 22; 134 (24):Journal ArticleAttenuated kidney oxidative metabolism in young adults with type 1 diabetes.
DOI:10.1172/JCI183984 PMID: 39436695 -
Yoon J, Liu Z, Alaba M, Bruggeman LA, Janmey PA, Arana CA, Ayenuyo O, Medeiros I, Eddy S, Kretzler M, Henderson JM, Nair V, Naik AS, Chang AN, Miller RT. 2024 Dec 9;PreprintGlomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy.
DOI:10.1101/2024.02.26.582201 PMID: 38948788 -
Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Dec; 149: 103296Journal ArticleLupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
DOI:10.1016/j.jaut.2024.103296 PMID: 39241536 -
Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM, BEAt-DKD consortium . Nat Commun, 2024 Nov 19; 15 (1): 10018Journal ArticleProfiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
DOI:10.1038/s41467-024-54089-1 PMID: 39562547 -
Pyle L, Choi YJ, Narongkiatikhun P, Sharma K, Waikar S, Layton A, Tommerdahl KL, de Boer I, Vigers T, Nelson RG, Lynch J, Brosius F, Saulnier PJ, Goodrich JA, Tryggestad JB, Isganaitis E, Bacha F, Nadeau KJ, van Raalte D, Kretzler M, Heerspink H, Bjornstad P. Clin J Am Soc Nephrol, 2024 Dec 1; 19 (12): 1603 - 1612.Journal ArticleProteomic Analysis Uncovers Multiprotein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus.
DOI:10.2215/CJN.0000000000000559 PMID: 39432369 -
Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, Robley C, Anglicheau D, Rabant M, Sannier A, Timsit M-O, Eddy S, Kretzler M, Ju W, Mechta-Grigoriou F. Nat Commun, 2024 Jan 25; 15 (1): 743Journal ArticleWNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
DOI:10.1038/s41467-024-44886-z PMID: 38272907 -
Gonzalez-Vicente A, Crawford DC, Bush WS, Wu Z, Bruggeman LA, Nair V, Eichinger F, Wessely O, Kretzler M, O’Toole JF, Sedor JR, Project KPM, Network NSS. medRxiv,PreprintAnalysis of Glomerular Transcriptomes from Nephrotic Patients Suggest APOL1 Risk Variants Impact Parietal Epithelial Cells
DOI:10.1101/2024.11.05.24316766