Jeffrey L Curtis, MD
Professor of Internal Medicine
[email protected]

Available to mentor

Jeffrey L Curtis, MD
Professor
  • About
  • Recent Publications
  • About

    Dr. Curtis received his medical degree from the Georgetown University School of Medicine. After a clinical residency in internal medicine and a year as Chief Medical Resident at the Johns Hopkins Bayview Medical Center, he spent two years as a Clinical Immunology Fellow at the National Institute on Aging, NIH. He then trained in Pulmonary & Critical Care Medicine (PCCM) at the University of California San Francisco, then joined the UCSF faculty at the San Francisco VA. Dr. Curtis was previously Chief, PCCM Section at the VA Ann Arbor Healthcare System (VAAAHS, 1990-2014) where he was scientific director of a Research Enhancement Award Program center in tobacco-induced lung diseases (1999-2012). He has held leadership roles in multiple COPD clinical trials, including the ongoing SPIROMICS, SOURCE, and COPDGene® studies. He is an Associate Editor of the American Journal of Respiratory & Critical Care Medicine and past-Chair of the American Thoracic Society (ATS) Scientific Assembly on Allergy, Immunology & Inflammation, from which he received a lifetime scientific achievement award in 2019. He received the Roger B. Grekin award from VAAAHS (2017); the John B. Barnwell award (named for the University of Michigan’s first Pulmonary Division Chief), VA’s highest award for clinical research (2019; and a Distinguished Achievement Award from ATS (2024). Dr. Curtis is an avid cyclist and downhill skier who enjoys cooking and eating many international cuisines, and reading, especially fiction and world history.

    Recent Publications See All Publications
    • Journal Article
      Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.
      Moll M, Hecker J, Platig J, Zhang J, Ghosh AJ, Pratte KA, Wang R-S, Hill D, Konigsberg IR, Chiles JW, Hersh CP, Castaldi PJ, Glass K, Dy JG, Sin DD, Tal-Singer R, Mouded M, Rennard SI, Anderson GP, Kinney GL, Bowler RP, Curtis JL, McDonald M-L, Silverman EK, Hobbs BD, Cho MH. EBioMedicine, 2024 Nov 6; 110: 105429 DOI:10.1016/j.ebiom.2024.105429
      PMID: 39509750
    • Journal Article
      Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.
      Arjomandi M, Zeng S, Barjaktarevic I, Bleecker ER, Bowler RP, Criner GJ, Comellas AP, Couper DJ, Curtis JL, Dransfield MT, Drummond MB, Fortis S, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Kanner RE, Krishnan JA, Labaki W, Ortega VE, Peters SP, Rennard SI, Cooper CB, Tashkin DP, Paine R, Woodruff PG. Ann Am Thorac Soc, 2024 Nov 25; DOI:10.1513/AnnalsATS.202405-527OC
      PMID: 39586032
    • Journal Article
      Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease
      Guo CJ, Godbole S, Labaki WW, Pratte KA, Curtis JL, Paine R, Hoffman E, Han M, Ohar J, Cooper C, Kechris KJ, DeMeo DL, Bowler RP. Metabolites, 14 (12): 647 DOI:10.3390/metabo14120647
    • Journal Article
      The Effect of Chronic Altitude Exposure on Chronic Obstructive Pulmonary Disease Outcomes in the SPIROMICS Cohort: An Observational Cohort Study.
      Suri R, Markovic D, Woo H, Arjomandi M, Barr RG, Bowler RP, Criner G, Curtis JL, Dransfield MT, Drummond MB, Fortis S, Han MK, Hoffman EA, Kaner RJ, Kaufman JD, Krishnan JA, Martinez FJ, Ohar J, Ortega VE, Paine R, Soler X, Woodruff PG, Hansel NN, Cooper CB, Tashkin DP, Buhr RG, Barjaktarevic IZ. Am J Respir Crit Care Med, 2024 Nov 15; 210 (10): 1210 - 1218. DOI:10.1164/rccm.202310-1965OC
      PMID: 38507607
    • Journal Article
      Validation of Systemic Complement Signatures in the Progression of Chronic Obstructive Pulmonary Disease.
      DiLillo KM, Ruvuna L, Pratte KA, Serban KA, Labaki WW, Han MK, Freeman CM, Bowler RP, Curtis JL, Arnold KB. Am J Respir Crit Care Med, 2024 Nov 15; 210 (10): 1269 - 1272. DOI:10.1164/rccm.202311-2059LE
      PMID: 39311978
    • Journal Article
      Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.
      Burnim M, Putcha N, LaFon D, Woo H, Azar A, Groenke L, Stampfli M, Schaub A, Fawzy A, Balasubramanian A, Fedarko N, Cooper CB, Bowler RP, Comellas A, Krishnan JA, Han MK, Couper D, Peters SP, Drummond MB, O'Neal W, Paine R, Criner G, Martinez FJ, Curtis JL, Barr G, Huang YJ, Woodruff P, Dransfield M, Hansel NN. Am J Respir Crit Care Med, 2024 Oct 23; DOI:10.1164/rccm.202311-2184OC
      PMID: 39441116
    • Journal Article
      B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort.
      Moll M, Xu Z, Boueiz A, Ryu MH, Silverman EK, Cho MH, Hersh CP, Sauler M, Polverino F, Kinney GL, Curtis JL, Crotty-Alexander LE, Vollmers C, Castaldi PJ. medRxiv, 2024 Oct 8; DOI:10.1101/2024.10.07.24315038
      PMID: 39417147
    • Journal Article
      Effect of sodium-glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, controlled, platform trial.
      Kosiborod MN, Windsor SL, Vardeny O, Berger JS, Reynolds HR, Boumakis S, Althouse AD, Solomon SD, Bhatt AS, Peikert A, Luther JF, Leifer ES, Kindzelski AL, Cushman M, Ng Gong M, Kornblith LZ, Khatri P, Kim KS, Baumann Kreuziger L, Javaheri A, Carpio C, Wahid L, Lopez-Sendon Moreno J, Alonso A, Ho MQ, Lopez-Sendon J, Lopes RD, Curtis JL, Kirwan B-A, Geraci MW, Neal MD, Hochman JS, ACTIV-4a Investigators . Lancet Diabetes Endocrinol, 2024 Oct; 12 (10): 725 - 734. DOI:10.1016/S2213-8587(24)00218-3
      PMID: 39250922