James Rae, PhD
Thomas H Simpson Legacy Professor of Cancer Research
Associate Professor of Internal Medicine
Associate Professor of Pharmacology
Medical School
[email protected]
Available to mentor
James Rae, PhD
Associate Professor
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Center Memberships
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Center MemberRogel Cancer Center
Recent Publications
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Cani AK, Dolce EM, Darga EP, Hu K, Liu C, Robinson D, Wu Y, Paoletti C, Luker GD, Tomlins SA, Udager AM, Henderson NC, Thomas DG, Rae JM, Arul CM, Cobain EF, Hayes DF. Clinical Cancer Research, 2026 Feb 23; 32 (4_Supplement): ps2-07-22-ps2-07-22Journal ArticleAbstract PS2-07-22: Serial, multi-omic, multi-analyte, liquid biopsy monitoring of metastatic lobular breast cancer to detect clinically-relevant heterogeneity and evolution
DOI:10.1158/1557-3265.sabcs25-ps2-07-22 -
Simon BG, Weiss CL, Chan D, Mangiante L, Ma Z, Smith NH, Meisner A, Rae JM, Speers CW, Albain KS, Karakas C, Bean GR, Mouron S, Quintela-Fandino M, Curtis C. 2026 Jan 2; bioRxiv,PreprintGenerative AI Enables Breast Cancer Genomic Subtype Prediction from Histology Images
DOI:10.64898/2025.12.29.692457 -
Pisano CE, Zeidane RA, Hochmuth E, Hauk B, Lichtman-Mikol S, Rana P, Tao M, Mercer V, McBean B, Pesch A, Hirsh N, Rae J, Pierce LJ, Cobain E, Lyons J, Speers C. International Journal of Radiation Oncology • Biology • Physics, 2025 Sep 28; 123 (1): e504 - e505.Journal ArticleOptimal Treatment Sequence for CDK4/6 Inhibitors and Radiation Combination Therapy in Triple Negative and Estrogen Receptor Positive Breast Cancer
DOI:10.1016/j.ijrobp.2025.06.2654 -
Jungles KM, Bishop CR, Wilson CM, Liu M, Jungles KR, Wilder-Romans K, Speers CW, Pierce LJ, Rae JM. Neoplasia United States, 2025 Aug 1; 66:Journal ArticleTargeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling
DOI:10.1016/j.neo.2025.101190 PMID: 40499340 -
Hadley A, Buning G, Henderson NC, Milliron KJ, Hulswit BB, Hipp LE, Pleasant VA, Rae JM, Pilewskie ML, Hayes DF, Henry NL, Merajver SD, Cobain EF. Clinical Cancer Research, 2025 Oct 7; 31 (12_Supplement): p1-05-15-p1-05-15 - p1-05-15-p1-05-15.Journal ArticleA real-world analysis of cancer prevention measures among individuals with hereditary breast and ovarian cancer (HBOC) syndromes and no personal history of malignancy
DOI:10.1158/1557-3265.sabcs24-p1-05-15 -
Stecklein SR, Barlow WE, Tsai J, Yablonovitch A, Rodler E, Kuhn P, Hicks J, Pathak HB, Hayes DF, Rae JM, Hortobagyi GN, Thompson AM, Godwin AK, Pusztai L, Sharma P. Journal of Clinical Oncology, 2025 May 30; 43 (16_suppl): 1012 - 1012.Journal ArticleAssessment of ctDNA somatic homologous recombination deficiency (HRD) in triple-negative breast cancer (TNBC) from SWOG S1416 trial.
DOI:10.1200/jco.2025.43.16_suppl.1012 -
Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2025 Apr 24; 68 (8): 9014 - 9015.Journal ArticleCorrection to "Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer".
DOI:10.1021/acs.jmedchem.5c00592 PMID: 40198894 -
Jungles KM, Bishop CR, Wilson C, Liu M, Speers CW, Pierce L, Rae J. Cancer Research, 2025 Apr 24; 85 (8_Supplement_1): 1829 - 1829.Journal ArticleAbstract 1829: Potentiating antitumoral type 1 interferon immune signaling in triple-negative breast cancer (TNBC) via combination treatment of Aurora kinase B (AURKB) inhibition and radiation therapy
DOI:10.1158/1538-7445.am2025-1829
