Available to mentor
Evan T. Keller, DVM, PhD is a Professor of Urology and Pathology, School of Medicine, University of Michigan. He is Director of the Single Cell Spatial Analysis Program; Associate Director for Shared Resource for the University of Michigan Comprehensive Rogel Cancer Center; Directs an NIH-funded Program Project on Prostate Cancer Bone Metastasis; and Co-Director of the Single Cell Analysis Core. Dr. Keller obtained Doctor of Veterinary Medicine (DVM) and Master of Preventive Veterinary Medicine (MPVM) degrees at University of California and attained American College of Veterinary Internal Medicine certification in Oncology and a PhD in Developmental Biology at the University of Wisconsin, Madison. His areas of research include (1) prostate cancer metastasis research, with a special emphasis on bone metastasis and the tumor microenvironment and (2) single cell and spatial analytic methods. Key research accomplishments include (1) defining importance of osteoclastic activity and targeting it in prostate cancer leading to clinical use of RANKL inhibitor (Denosumab); (2) identification of raf kinase inhibitor protein (RKIP) as a novel metastasis suppressor gene; (3) determining the importance of the Wnt pathway in bone metastasis; and (4) defining interleukin-6 as a contributor to castration resistant prostate cancer.
https://sites.google.com/umich.edu/keller-lab/home
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DVMUniversity of California, Davis, United States
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MPVMUniversity of California, Davis, Ann Arbor
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PhDUniversity of Wisconsin, Madison, United States
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
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Center MemberCaswell Diabetes Institute
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Center MemberBiointerfaces Institute
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Center MemberPrecision Health Initiative
Research interests include (1) prostate cancer metastasis research, with a special emphasis on bone metastasis and the tumor microenvironment; (2) single cell analytic methods; (3) drug resistance; (4) spatial analytics.
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May AM, Williams C, Hagler S, McNiff M, Robinson T, Salami S, Udager A, Keller ET. Journal of Urology, 2024 May; 211 (5S): e366Journal ArticlePD16-04 SPATIAL ANALYSIS OF PRIMARY AND METASTATIC LESIONS IN SARCOMATOID RENAL CELL CARCINOMA REVEALS INSIGHT TO TUMOR BIOLOGY AND IMMUNE MICROENVIRONMENT
DOI:10.1097/01.ju.0001009560.23593.56.04 -
May AM, Wainstein M, McGue J, Robinson T, Mehra R, Salami SS, Frankel T, Udager A, Keller ET. Journal of Urology, 2024 May; 211 (5S): e367Journal ArticlePD16-05 EPITHELIAL TO MESENCHYMAL TRANSITION (EMT) AND PD-1/PD-L1 SIGNALING PROVIDE RECIPROCAL FEEDBACK IN RENAL CELL CARCINOMA PROGRESSION WITH IMPLICATIONS FOR IMMUNOTHERAPY RESPONSE
DOI:10.1097/01.ju.0001009560.23593.56.05 -
Dong L, Hu C, Ma Z, Huang Y, Shelley G, Kuczler MD, Kim C-J, Witwer KW, Keller ET, Amend SR, Xue W, Pienta KJ. 2024 Mar 29;PreprintUrinary extracellular vesicle-derived miR-126-3p predicts lymph node invasion in patients with high-risk prostate cancer.
DOI:10.21203/rs.3.rs-4164213/v1 PMID: 38585988 -
Wainstein MD, McGue J, Robinson T, Mehra R, Salami SS, Frankel T, Udager A, Keller ET, May AM, Jiang J. Urologic Oncology Seminars and Original Investigations, 2024 Mar; 42: s5 - s6.Journal ArticleEPITHELIAL TO MESENCHYMAL TRANSITION (EMT) AND PD-1/PD-L1 SIGNALING PROVIDE RECIPROCAL FEEDBACK IN RENAL CELL CARCINOMA PROGRESSION WITH IMPLICATIONS FOR IMMUNOTHERAPY RESPONSE
DOI:10.1016/j.urolonc.2024.01.048 -
May A, Williams C, The S, McGue J, Wainstein M, Shelley G, Robinson T, Salami SS, Mehra R, Frankel T, Udager AM, Keller ET. Journal of Clinical Oncology, 2024 Feb 1; 42 (4_suppl): 480 - 480.Journal ArticleAssociation of transitional gradient from clear cell to sarcomatoid renal cell carcinoma with macrophage/tumor cell crosstalk.
DOI:10.1200/jco.2024.42.4_suppl.480 -
Zheng C, Yao H, Lu L, Li H, Zhou L, He X, Xu X, Xia H, Ding S, Yang Y, Wang X, Wu M, Xue L, Chen S, Peng X, Cheng Z, Wang Y, He G, Fu S, Keller ET, Liu S, Jiang Y-Z, Deng X. Int J Biol Sci, 2024 20 (6): 2130 - 2148.Journal ArticleDysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin.
DOI:10.7150/ijbs.94058 PMID: 38617541 -
Robinson T, Escara-Wilke J, Dai J, Zimmermann J, Keller ET. Prostate, 2023 Sep; 83 (13): 1247 - 1254.Journal ArticleA CXCR4 inhibitor (balixafortide) enhances docetaxel-mediated antitumor activity in a murine model of prostate cancer bone metastasis.
DOI:10.1002/pros.24584 PMID: 37244751 -
May A, Williams C, The S, McGue J, Kim S, Schurman N, Shelley G, Robinson T, Salami S, Mehra R, Frankel T, Udager A, Keller E. Cancer Research, 2023 Aug 15; 83 (16_Supplement): pr014 - pr014.Journal ArticleAbstract PR014: Macrophage induced epithelial to mesenchymal transition in sarcomatoid renal cell carcinoma
DOI:10.1158/1538-7445.kidney23-pr014