Max S Wicha, MD
Madeline and Sidney Forbes Professor of Oncology and Professor of Internal Medicine
[email protected]

Available to mentor
Max S Wicha, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • Biology Degree
      State University of NY at Stony Brook, United States, 1970
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Biointerfaces Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Global REACH
    Research Overview

    Mammary cell biology
    * Regulation of mammary growth, differentiation and apoptosis
    * Stem cells in normal mammary development and breast cancer
    * Cancer stem cell therapeutics

    Recent Publications See All Publications
    • Preprint
      Long Non-Coding RNAs: Key Regulators of Tumor Epithelial/Mesenchymal Plasticity and Cancer Stemness
      Yuan Y, Tang Y, Fang Z, Wen J, Wicha MS, Luo M. Preprints.org, DOI:10.20944/preprints202412.2254.v1
    • Journal Article
      Simultaneous Targeting of NQO1 and SOD1 Eradicates Breast Cancer Stem Cells via Mitochondrial Futile Redox Cycling.
      Luo M, Shen N, Shang L, Fang Z, Xin Y, Ma Y, Du M, Yuan Y, Hu C, Tang Y, Huang J, Wei W, Lee MR, Hergenrother PJ, Wicha MS. Cancer Res, 2024 Dec 16; 84 (24): 4264 - 4282. DOI:10.1158/0008-5472.CAN-24-0800
      PMID: 39264695
    • Journal Article
      Redox regulation of cancer stem cells: Biology and therapeutic implications
      Du M, Zhang J, Wicha MS, Luo M. MedComm - Oncology, 2024 Dec 1; 3 (4): DOI:10.1002/mog2.70005
    • Journal Article
      Abstract IA004: Early cancer dissemination: Circulating tumor cells in ductal carcinoma in situ patients
      Nagrath S, Nagpal N, Rupp B, Hong Y, Behbod F, Wicha M. Clinical Cancer Research, 2024 Nov 13; 30 (21_Supplement): ia004 - ia004. DOI:10.1158/1557-3265.liqbiop24-ia004
    • Journal Article
      SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma.
      Elaimy AL, El-Derany MO, James J, Wang Z, Pearson AN, Holcomb EA, Huber AK, Gijón M, Bell HN, Sanghvi VR, Frankel TL, Su GL, Tapper EB, Tai AW, Ramnath N, Centonze CP, Dobrosotskaya I, Moeller JA, Bryant AK, Elliott DA, Choi E, Evans JR, Cuneo KC, Fitzgerald TJ, Wahl DR, Morgan MA, Chang DT, Wicha MS, Lawrence TS, Shah YM, Green MD. JCI Insight, 2024 Nov 8; 9 (21): DOI:10.1172/jci.insight.184826
      PMID: 39287988
    • Proceeding / Abstract / Poster
      2 Integrin β1 high /β3 high cancer stem cell-directed targeting of melanoma
      Fang J, Wang F, Xin Y, Moon JJ, Chang AE, Wicha M, Deng Z, Li Q. 2024 Nov; a2 - a5. DOI:10.1136/jitc-2024-sitc2024.0002
    • Journal Article
      Natural Killer Cell Regulation of Breast Cancer Stem Cells Mediates Metastatic Dormancy.
      Bushnell GG, Sharma D, Wilmot HC, Zheng M, Fashina TD, Hutchens CM, Osipov S, Burness M, Wicha MS. Cancer Res, 2024 Oct 15; 84 (20): 3337 - 3353. DOI:10.1158/0008-5472.CAN-24-0030
      PMID: 39106452
    • Journal Article
      Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
      Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Cell, 2024 Aug 22; 187 (17): 4713 - 4732.e19. DOI:10.1016/j.cell.2024.06.012
      PMID: 38968937