Max S Wicha, MD

 Max Wicha, MD
Madeline and Sidney Forbes Professor of Oncology and Professor of Internal Medicine
Medical School
[email protected]
Available to mentor
Max S Wicha, MD
Max Wicha, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

  • Manage Your Profile

    • Qualifications
    • Biology Degree
      State University of NY at Stony Brook, United States
      1966 - 1970

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Biointerfaces Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Global REACH

    Research Overview

    Mammary cell biology
    * Regulation of mammary growth, differentiation and apoptosis
    * Stem cells in normal mammary development and breast cancer
    * Cancer stem cell therapeutics

    Recent Publications

     See All Publications
    • Journal Article
      Abstract 184: TNF-alpha plays pleiotropic role in innate immune activation and blood-brain barrier disruption driving brain metastasis.
      Celiker N, Alkan FK, Alkan HK, Caglayan A, Lawal A, Al Achkar M, Max WS, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 184 - 184. DOI:10.1158/1538-7445.am2026-184
    • Journal Article
      Abstract 2375: Stress-responsive immune microenvironment in triple-negative breast cancer among African American women
      Lawal AM, Alkan FK, Alkan HK, Caglayan AB, Celiker N, Temby B, WICHA M, Al Achkar M, Purrington K, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 2375 - 2375. DOI:10.1158/1538-7445.am2026-2375
    • Journal Article
      Abstract 3431: Neutrophil-like monocytes (NeuMos) with high levels of CXCL2 expression orchestrate systemic granulopoiesis and drive immunotherapy resistance in TNBC
      Alkan F, Alkan HK, Caglayan A, Caglayan A, Lawal A, Celiker N, Shi H, Vogl T, Neamati N, Max W, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 3431 - 3431. DOI:10.1158/1538-7445.am2026-3431
    • Journal Article
      Abstract 6110: Systemic inflammation induced by calprotectin (S100A8/S100A9 complex) triggers reactivation of dormant cells in mouse models of breast cancer
      Caglayan AB, Xin Y, Caglayan A, Nagaraja S, Sharma D, Hager C, Koksalar-Alkan F, Alkan HK, Burness M, Korkaya H, Wicha MS. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6110 - 6110. DOI:10.1158/1538-7445.am2026-6110
    • Journal Article
      Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.
      Fujiwara H, Seike K, Brooks MD, Mathew AV, Kovalenko I, Pal A, Lee H-J, Peltier D, Kim S, Liu C, Oravecz-Wilson K, Li L, Sun Y, Byun J, Maeda Y, Wicha MS, Saunders TL, Rehemtulla A, Lyssiotis CA, Pennathur S, Reddy P. Nat Immunol, 2026 Mar 24; DOI:10.1038/s41590-026-02504-8
      PMID: 41876720
    • Preprint
      Exploring the Influence of Chemical Exposures in Breast Cancer Disparities: High-Throughput Transcriptomic Analysis in Normal Breast Cells from Diverse Donors
      Zhao N, Zhao P, Tapaswi A, Polemi K, Thong T, Sexton J, Charles S, Wicha MS, Svoboda L, Zhou X, Colacino JA. 2026 Feb 26; bioRxiv, DOI:10.64898/2026.02.23.707203
    • Presentation
      Metabolic and immunologic targeting of breast cancer stem cells
      2026 Feb 4;
    • Journal Article
      Transcriptional profiling clarifies a program of enzalutamide extreme non-response in lethal prostate cancer
      Kumaraswamy A, Hu YM, Yates JA, Zhang C, Rodansky E, Khokhani D, Flores D, Duan Z, Zhang Y, Tabatabaei S, Slottke R, Ye S, Lara P, Foye A, Ryan CJ, Quigley DA, Huang J, Aggarwal R, Reiter RE, Wicha MS, Beer TM, Rettig M, Gleave M, Evans CP, Witte ON, Stuart JM, Thomas GV, Feng FY, Small EJ, Xia Z, Alumkal JJ. Npj Precision Oncology, 2025 Dec 1; 9 (1): DOI:10.1038/s41698-025-01002-8