Lili Liu, PhD

Lili Liu
Assistant Professor of Internal Medicine
Assistant Professor of Computational Medicine and Bioinformatics
Medical School
University of Michigan
Internal Medicine and Computational Medicine and Bioinformatics
11500 West Medical Center Drive
Ann Arbor, MI 481096
[email protected]
Available to mentor
Lili Liu, PhD
Lili Liu
Assistant Professor
  • About
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  • Qualifications
  • Research Overview
  • Recent Publications
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  • About

    Dr. Liu’s research focuses on dissecting the genetic and molecular architecture of complex kidney diseases, with a specialized interest in glomerular disorders. Her work leverages an integrative, multi-disciplinary approach that combines genomic and multi-omics data with advanced imaging and detailed clinical phenotyping to investigate how genetic and molecular variation influence kidney structure, function, and disease progression.

    Motivated by the promise of precision medicine, Dr. Liu aims to move beyond identifying disease-associated risk factors to uncovering causal biological pathways that may inform the development of targeted, personalized therapies. Her research sits at the intersection of data science, molecular biology, and clinical pathology, with a strong emphasis on translational impact. Through this integrative framework, Dr. Liu seeks to identify actionable biomarkers and therapeutic targets to ultimately improve the clinical management and outcomes of patients with kidney disease.

    Links

    • https://medschool.umich.edu/department-news/advancing-kidney-precision-medicine-conversation-dr-lili-liu

    Qualifications

    • PhD, Bioinformatics
      Zhejiang University, Hangzhou, China
      2010 - 2016
    • B.Sc., Biotechnology
      Northeast Agricultural University, Harbin, China
      2006 - 2010

    Research Overview

    Defining genetic basis of glomerular disease and related traits for the development of targeted therapies and improved disease management.

    Joint analysis of biopsy images and multi-omics data to uncover genetic and molecular basis of kidney structure and function.

    Identification of non-invasive biomarkers of renal disease through systems genetics.

    Recent Publications

    See All Publications
    • Presentation
      Atlas of Glomerular Disease-Specific Genetic Effects on Gene Regulation in Blood Empowers New Gene Discovery Studies: TH-OR031
      Liu L. 2026 Feb 5;
    • Proceeding / Abstract / Poster
      Genome-Wide Association Study (GWAS) of Serum Galactose-Deficient IgA1 Uncovers Shared Genetic Determinants with IgAN: TH-PO0633
      Liu L. 2026 Feb 5;
    • Proceeding / Abstract / Poster
      Impact of Polygenic Scores on Kidney Failure Risk Prediction Models in IgAN: FR-OR028
      Liu L. 2026 Feb 5;
    • Journal Article
      Serum IgA isotypes are associated with percent emphysema, wall thickness and lung function decline
      Pottinger T, Liu Z, Liu L, Buschur KL, Curtis JL, Manichaikul A, Rich SS, Ortega VE, Bleecker ER, Meyers DA, Hoffman EA, Smith B, Novak J, Kiryluk K, Barr RG. Thorax, 2025 Nov 1; 80 (11): 829 - 837. DOI:10.1136/thorax-2025-222990
      PMID: 40846486
    • Journal Article
      Association of Collapsing Glomerulopathy with Donor Apolipoprotein L1 Risk Variants in Kidney Allografts from Black Donors.
      Batal I, Mikhailov AV, Husain SA, Nuccitelli RA, Zanoni F, Liu L, Lim TY, Mohan S, DiFranza LT, Kudose S, Santoriello D, Sekulic M, Stokes MB, Markowitz GS, Ratner LE, D'Agati VD, Vasilescu E-R, Gardner KL, Sanna-Cherchi S, Freedman BI, Kiryluk K, Mena Gutierrez AM. Clin J Am Soc Nephrol, 2025 Jul 7; 20 (9): 1268 - 1276. DOI:10.2215/CJN.0000000778
      PMID: PMC12445388
    • Journal Article
      Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.
      Luo Y, Khan A, Liu L, Lee CH, Perreault GJ, Pomenti SF, Gourh P, Kiryluk K, Bernstein EJ. Arthritis Rheumatol, 2025 Jun; 77 (6): 727 - 739. DOI:10.1002/art.43081
      PMID: PMC12124972
    • Journal Article
      Noninvasive Diagnostic Strategies for Membranous Nephropathy in the Nephrotic Syndrome Study Network.
      Zee J, Hogan JJ, Abdullah A, Liu L, Kiryluk K, Beck LH. Clin J Am Soc Nephrol, 2025 May 1; 20 (5): 697 - 705. DOI:10.2215/CJN.0000000671
      PMID: PMC12097183
    • Presentation
      “Novel Mechanisms and Therapies for Pediatric IgA-Associated Vasculitis”
      Liu L. 2026 Jan 16;

    Featured News & Stories

    Lili Liu
    Department News

    Advancing Kidney Precision Medicine: A Conversation with Dr. Lili Liu

    Lili Liu, PhD is a newly appointed faculty member at Michigan Medicine in the Department of Internal Medicine Division of Nephrology and Department of Computational Medicine and Bioinformatics who brings a dynamic background spanning bioinformatics, genetics, and translational nephrology. With a passion for precision medicine and a drive to translate genomic discoveries into clinical applications, Dr. Liu is poised to make a significant impact on kidney research and mentorship at Michigan.