Lili Liu, PhD
Internal Medicine and Computational Medicine and Bioinformatics
11500 West Medical Center Drive
Ann Arbor, MI 481096
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About
Dr. Liu’s research focuses on dissecting the genetic and molecular architecture of complex kidney diseases, with a specialized interest in glomerular disorders. Her work leverages an integrative, multi-disciplinary approach that combines genomic and multi-omics data with advanced imaging and detailed clinical phenotyping to investigate how genetic and molecular variation influence kidney structure, function, and disease progression.
Motivated by the promise of precision medicine, Dr. Liu aims to move beyond identifying disease-associated risk factors to uncovering causal biological pathways that may inform the development of targeted, personalized therapies. Her research sits at the intersection of data science, molecular biology, and clinical pathology, with a strong emphasis on translational impact. Through this integrative framework, Dr. Liu seeks to identify actionable biomarkers and therapeutic targets to ultimately improve the clinical management and outcomes of patients with kidney disease.
Links
https://medschool.umich.edu/department-news/advancing-kidney-precision-medicine-conversation-dr-lili-liu
Qualifications
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PhD, BioinformaticsZhejiang University, Hangzhou, China
2010 - 2016
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B.Sc., BiotechnologyNortheast Agricultural University, Harbin, China
2006 - 2010
Research Overview
Defining genetic basis of glomerular disease and related traits for the development of targeted therapies and improved disease management.
Joint analysis of biopsy images and multi-omics data to uncover genetic and molecular basis of kidney structure and function.
Identification of non-invasive biomarkers of renal disease through systems genetics.
Recent Publications
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Liu L. 2026 Feb 5;PresentationAtlas of Glomerular Disease-Specific Genetic Effects on Gene Regulation in Blood Empowers New Gene Discovery Studies: TH-OR031
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Liu L. 2026 Feb 5;Proceeding / Abstract / PosterGenome-Wide Association Study (GWAS) of Serum Galactose-Deficient IgA1 Uncovers Shared Genetic Determinants with IgAN: TH-PO0633
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Liu L. 2026 Feb 5;Proceeding / Abstract / PosterImpact of Polygenic Scores on Kidney Failure Risk Prediction Models in IgAN: FR-OR028
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Pottinger T, Liu Z, Liu L, Buschur KL, Curtis JL, Manichaikul A, Rich SS, Ortega VE, Bleecker ER, Meyers DA, Hoffman EA, Smith B, Novak J, Kiryluk K, Barr RG. Thorax, 2025 Nov 1; 80 (11): 829 - 837.Journal ArticleSerum IgA isotypes are associated with percent emphysema, wall thickness and lung function decline
DOI:10.1136/thorax-2025-222990 PMID: 40846486 -
Batal I, Mikhailov AV, Husain SA, Nuccitelli RA, Zanoni F, Liu L, Lim TY, Mohan S, DiFranza LT, Kudose S, Santoriello D, Sekulic M, Stokes MB, Markowitz GS, Ratner LE, D'Agati VD, Vasilescu E-R, Gardner KL, Sanna-Cherchi S, Freedman BI, Kiryluk K, Mena Gutierrez AM. Clin J Am Soc Nephrol, 2025 Jul 7; 20 (9): 1268 - 1276.Journal ArticleAssociation of Collapsing Glomerulopathy with Donor Apolipoprotein L1 Risk Variants in Kidney Allografts from Black Donors.
DOI:10.2215/CJN.0000000778 PMID: PMC12445388 -
Luo Y, Khan A, Liu L, Lee CH, Perreault GJ, Pomenti SF, Gourh P, Kiryluk K, Bernstein EJ. Arthritis Rheumatol, 2025 Jun; 77 (6): 727 - 739.Journal ArticleCross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.
DOI:10.1002/art.43081 PMID: PMC12124972 -
Zee J, Hogan JJ, Abdullah A, Liu L, Kiryluk K, Beck LH. Clin J Am Soc Nephrol, 2025 May 1; 20 (5): 697 - 705.Journal ArticleNoninvasive Diagnostic Strategies for Membranous Nephropathy in the Nephrotic Syndrome Study Network.
DOI:10.2215/CJN.0000000671 PMID: PMC12097183 -
Liu L. 2026 Jan 16;Presentation“Novel Mechanisms and Therapies for Pediatric IgA-Associated Vasculitis”
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