Warren W Pan, MD, PhD, MPhil
Ophthalmology and Visual Sciences
1000 Wall Street
Ann Arbor, MI 48105
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Qualifications
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FellowshipUniversity of Michigan, Ophthalmology, Ann Arbor, United States
2024 - 2026
Clinical Fellowship
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ResidencyUniversity of Michigan, Ophthalmology, Ann Arbor, United States
2021 - 2024
Residency
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InternshipUniversity of Michigan, Internal Medicine, Ann Arbor, United States
2020 - 2021
Internship
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MDUniversity of Michigan, Ann Arbor, United States
2012 - 2020
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MPhilUniversity of Cambridge, Cambridge, United Kingdom
2018 - 2019
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PhDUniversity of Michigan, Ann Arbor, United States
2014 - 2017
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ABHarvard University, Cambridge, United States
2007 - 2011
Research Overview
- My laboratory focuses on understanding and treating retinal vascular diseases, including diabetic retinopathy and radiation retinopathy—two of the most common causes of vision loss. My research integrates high-throughput quantitative proteomics, multimodal retinal imaging, and preclinical animal models to build a translational pipeline from molecular discovery to therapeutic validation. Ultimately, my goal is to complete the preclinical evidence base necessary to launch early-phase clinical trials to treat patients with these blinding conditions.
- We also investigate the economics of retinal care to improve value, access, and sustainability. Using time-driven activity-based costing and large-scale claims analysis, my research examines the true cost of vitreoretinal procedures, geographic and community-level disparities in care delivery, and the impact of economics on practice pattern changes. Ultimately, my goal is to generate evidence that informs reimbursement policy, reduces unnecessary variation, and ensures that high-quality retinal care remains accessible and financially viable for all patients.
Recent Publications
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Dell'Orco J, Pan W, Allison MB, Tomlinson AJ, Wean J, Sabatini PV, Rhodes CJ, Olson DP, Myers MG, Goforth PB. Molecular Metabolism, 2026 Jun 1; 108:Journal ArticleIncreased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity
DOI:10.1016/j.molmet.2026.102378 PMID: 42082152 -
Pan WW, Waters I, Yousif J, Reichert ZR, Johnson MW, Miller J, Jayasundera KT. JAMA Ophthalmology, 2026 Feb 19; 144 (2): 204 - 206.Journal ArticleAcute and Substantial Vision Loss After Pembrolizumab Immunotherapy for Bladder Cancer
DOI:10.1001/jamaophthalmol.2025.5068 PMID: 41379437 -
Pan WW, Demirci H, Sundstrom J, Wubben T. 2025 Oct 6;Proceeding / Abstract / PosterVitreous proteomics identifies critical mechanistic and therapeutic markers in radiation retinopathy
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Pan WW, Mansoor M, Riccardi D, Madison JA, Wubben TJ, Kodati S, Miller J. Ocular Immunology and Inflammation, 2025 Jun 20; 33 (8): 1869 - 1872.Journal ArticleTocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment
DOI:10.1080/09273948.2025.2519849 PMID: PMC12255164 -
Eton EA, Pan WW, Besirli CG, Zacks DN, Wubben TJ. Journal of Vitreoretinal Diseases, 2025 Sep 1; 9 (5): 607 - 613.Journal ArticleIncidence and Impact of Outer Retinal Folds After Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment Repair
DOI:10.1177/24741264251350023 -
Pan WW, Weh KM, Chaudhury S, Fernando R, Hager H, Wen B, Chinnaswamy K, Stuckey JA, Rech JC, Besirli CG, Weh E, Wubben TJ. Translational Vision Science and Technology, 2025 Jul 1; 14 (7):Journal ArticleA Novel, Long-Acting, Small Molecule PKM2 Activator and Its Potential Broad Application Against Photoreceptor Degeneration
DOI:10.1167/tvst.14.7.26 PMID: 40742037 -
Pan WW, Young C, Portney D, Fowler A, Mian SI, Eton EA, Wubben TJ. 2025 Jul 6;Proceeding / Abstract / PosterComparative Cost Analysis of Secondary Intraocular Lens Surgeries Using Time-Driven, Activity -Based Costing
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Besirli C, Valikodath N, Pan WW, Fleifil S, Portney DS. 2025 Jul 30;Proceeding / Abstract / PosterComparative cost analysis of pediatric and adult retinal detachment repairs using time-driven, activity-based costing