Hiroyuki Arakawa

Hiroyuki Arakawa
Assistant Research Scientist
Pharmacology
Medical School
[email protected]
Available to mentor
Hiroyuki Arakawa
Hiroyuki Arakawa
Assistant Research Scientist
  • Qualifications
  • Research Overview
  • Recent Publications
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  • Qualifications

    • Associate Professor
      University of the Ryukyus, School of Medicine, Okinawa, Japan
      2020 - 2023
      Other
    • Assistant Professor
      University of Maryland, Baltimore, Anatomy and Neurobiology, Baltimore, United States
      2018 - 2020
      Other
    • Director of Rodent behavior core
      Case Western Reserve University, Cleveland, United States
      2014 - 2018
      Other
    • Visiting lecturer
      Concordia College - Minnesota, Psychology, Moorhead, United States
      2013 - 2014
      Internship
    • Postdoctoral fellow
      University of Maryland, Baltimore, Baltimore, United States
      2010 - 2013
      Postdoctoral Research
    • Research associate
      Binghamton University, Psychology, Binghamton, United States
      2007 - 2010
      Postdoctoral Fellowship
    • Postdoctoral fellow
      University of Hawaii at Manoa, Honolulu, United States
      2005 - 2007
      Postdoctoral Fellowship
    • PhD
      Nagoya University, Nagoya, Japan
      2000 - 2006

    Research Overview

    I have recently moved from University of the Ryukyus, Japan served as an Associate Professor of Physiology to U-M Pharmacology, as an Assistant Research Scientist, to ensure my enthusiasm for research proceed further. My background are psychology and neuroscience, with specific training and expertise in behavioral mechanisms and circuit-manipulation in rodent models. My research aims to illustrate neural circuits dynamics regulating sociability that sustains amicable social life and deficiency relevant to autism spectrum disorders (ASD). In particular, neuropeptides, oxytocin and vasopressin are my primary targets both of which play a key role in the neural regulation of socioemotional behaviors and also as a mediator for opioid-related neural processes. With this in my mind, I have pursued to uncover 1) how prosocial (i.e., positive social) relationship can sustain development of neural circuits and mental health, 2) how ensemble of neural circuits determines sequence of natural social behaviors and 3) responsible decifiency for behavioral symptoms of ASD. Furthermore, I would examine the neural circuits of these neuropeptides in the regulation of opioid neural processes.

    Recent Publications

    See All Publications
    • Journal Article
      Modern assays for assessing pain and related nociceptive and defensive actions in rodent models
      Arakawa H. Behavioural Brain Research, 2026 Jan 5; 496: DOI:10.1016/j.bbr.2025.115854
      PMID: 41022255
    • Journal Article
      Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism
      Higuchi Y, Ozawa A, Kobayashi R, Konno T, Arakawa H. Open Biology, 2025 Aug 27; 15 (8): DOI:10.1098/rsob.240387
      PMID: 40858267
    • Journal Article
      Interpreting mouse’s intention from analysis of prosocial behavior
      Arakawa H. Lab Animal, 2025 Jun 1; 54 (6): 139 - 140. DOI:10.1038/s41684-025-01561-0
      PMID: 40437233
    • Journal Article
      Serotonin circuits act cooperatively with pathophysiology of opioid use disorder
      Hiroyuki A, Akihiko O. Addiction Neuroscience, 2025 Mar 1; 14: DOI:10.1016/j.addicn.2024.100187
    • Journal Article
      The posterior intralaminar thalamic nucleus promotes nose-to-nose contacts leading to prosocial reception in the sequence of mouse social interaction
      Arakawa H, Tokashiki M. European Journal of Neuroscience, 2024 Oct 1; 60 (7): 5731 - 5749. DOI:10.1111/ejn.16520
      PMID: 39210622
    • Journal Article
      Adolescent social isolation disrupts developmental tuning of neuropeptide circuits in the hypothalamus to amygdala regulating social and defensive behavior
      Arakawa H, Tokashiki M, Higuchi Y, Konno T. Peptides, 2024 May 1; 175: DOI:10.1016/j.peptides.2024.171178
      PMID: 38368908
    • Chapter
      Assessing Disability in Rodent Models of Human Disorders
      Arakawa H. 2024 Apr 11; The Palgrave Encyclopedia of Disability, 1 - 7. DOI:10.1007/978-3-031-40858-8_104-1
    • Chapter
      The Usability of Mouse Models to Study the Neural Circuity in Autism Spectrum Disorder: Regulatory Mechanisms of Core Behavioral Symptoms
      Arakawa H, Higuchi Y. 2024 Jan 1; Neurobiology of Autism Spectrum Disorders, 105 - 121. DOI:10.1007/978-3-031-42383-3_6

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