Hiroyuki Arakawa
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Qualifications
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Associate ProfessorUniversity of the Ryukyus, School of Medicine, Okinawa, Japan
2020 - 2023
Other
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Assistant ProfessorUniversity of Maryland, Baltimore, Anatomy and Neurobiology, Baltimore, United States
2018 - 2020
Other
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Director of Rodent behavior coreCase Western Reserve University, Cleveland, United States
2014 - 2018
Other
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Visiting lecturerConcordia College - Minnesota, Psychology, Moorhead, United States
2013 - 2014
Internship
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Postdoctoral fellowUniversity of Maryland, Baltimore, Baltimore, United States
2010 - 2013
Postdoctoral Research
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Research associateBinghamton University, Psychology, Binghamton, United States
2007 - 2010
Postdoctoral Fellowship
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Postdoctoral fellowUniversity of Hawaii at Manoa, Honolulu, United States
2005 - 2007
Postdoctoral Fellowship
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PhDNagoya University, Nagoya, Japan
2000 - 2006
Research Overview
I have recently moved from University of the Ryukyus, Japan served as an Associate Professor of Physiology to U-M Pharmacology, as an Assistant Research Scientist, to ensure my enthusiasm for research proceed further. My background are psychology and neuroscience, with specific training and expertise in behavioral mechanisms and circuit-manipulation in rodent models. My research aims to illustrate neural circuits dynamics regulating sociability that sustains amicable social life and deficiency relevant to autism spectrum disorders (ASD). In particular, neuropeptides, oxytocin and vasopressin are my primary targets both of which play a key role in the neural regulation of socioemotional behaviors and also as a mediator for opioid-related neural processes. With this in my mind, I have pursued to uncover 1) how prosocial (i.e., positive social) relationship can sustain development of neural circuits and mental health, 2) how ensemble of neural circuits determines sequence of natural social behaviors and 3) responsible decifiency for behavioral symptoms of ASD. Furthermore, I would examine the neural circuits of these neuropeptides in the regulation of opioid neural processes.
Recent Publications
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Arakawa H. Behavioural Brain Research, 2026 Jan 5; 496:Journal ArticleModern assays for assessing pain and related nociceptive and defensive actions in rodent models
DOI:10.1016/j.bbr.2025.115854 PMID: 41022255 -
Higuchi Y, Ozawa A, Kobayashi R, Konno T, Arakawa H. Open Biology, 2025 Aug 27; 15 (8):Journal ArticleFunctional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism
DOI:10.1098/rsob.240387 PMID: 40858267 -
Arakawa H. Lab Animal, 2025 Jun 1; 54 (6): 139 - 140.Journal ArticleInterpreting mouse’s intention from analysis of prosocial behavior
DOI:10.1038/s41684-025-01561-0 PMID: 40437233 -
Hiroyuki A, Akihiko O. Addiction Neuroscience, 2025 Mar 1; 14:Journal ArticleSerotonin circuits act cooperatively with pathophysiology of opioid use disorder
DOI:10.1016/j.addicn.2024.100187 -
Arakawa H, Tokashiki M. European Journal of Neuroscience, 2024 Oct 1; 60 (7): 5731 - 5749.Journal ArticleThe posterior intralaminar thalamic nucleus promotes nose-to-nose contacts leading to prosocial reception in the sequence of mouse social interaction
DOI:10.1111/ejn.16520 PMID: 39210622 -
Arakawa H, Tokashiki M, Higuchi Y, Konno T. Peptides, 2024 May 1; 175:Journal ArticleAdolescent social isolation disrupts developmental tuning of neuropeptide circuits in the hypothalamus to amygdala regulating social and defensive behavior
DOI:10.1016/j.peptides.2024.171178 PMID: 38368908 -
Arakawa H. 2024 Apr 11; The Palgrave Encyclopedia of Disability, 1 - 7.ChapterAssessing Disability in Rodent Models of Human Disorders
DOI:10.1007/978-3-031-40858-8_104-1 -
Arakawa H, Higuchi Y. 2024 Jan 1; Neurobiology of Autism Spectrum Disorders, 105 - 121.ChapterThe Usability of Mouse Models to Study the Neural Circuity in Autism Spectrum Disorder: Regulatory Mechanisms of Core Behavioral Symptoms
DOI:10.1007/978-3-031-42383-3_6
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