Yilei Cui, PhD
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About
Yilei Cui is an Assistant Research Scientist in the University of Michigan Department of Dermatology. Dr. Cui's research focuses on cutaneous biology, aging, and cancer; the regulation of dermal extracellular matrix homeostasis; and the role of epidermal and stromal interactions in promoting skin tumorigenesis, and also engages in mechanism-based discovery of novel therapeutic molecules and biomarkers.
Dr. Cui's current research centers on immune-mediated skin disorders and inflammaging; the molecular basis of chronological aging, photoaging, and epigenetic aging clocks; stem cells in skin aging and cancer; and identifying biomarkers for healthy aging and therapeutic targets for cancer treatment, employing state-of-the-art methods.
Center Memberships
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Center MemberAI and Digital Health Innovation
Research Overview
Dr. Cui is involved in basic science, translational, and clinical research to promote health.
• Cancer Immunity
• Cutaneous Aging
• Dermal Fibroblast Function
• Pathophysiology of Skin Disorders
• Compounds and Therapeutic Molecules
Recent Publications
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Cui Y, Shi M, Worthen C, Grill S, Nandakumar J, Zhao Y, Fisher GJ. Journal of Cell Communication and Signaling, 2026 Oct 7; 20 (4):Journal ArticleDermal fibroblasts cultured from aged human skin display a pro‐inflammatory phenotype
DOI:10.1002/ccs3.70117 -
Parnell N, Cao X, Beumer JH, Braun TM, Cui Y, Fisher GJ, Hou G, Holleran J, Churay T, Rozwadowski M, Heider L, Vander Lugt MT, Kitko CL, Rahrig AL, Peres E, Williams KM, Talano J-A, Fabrizio VA, Abusin G, Yanik GA, Magenau J, Riwes M, Geer MJ, Anand S, Ghosh M, Pawarode A, Votruba K, Reddy P, Choi SW. JCI Insight, 2026 Sep 24;Journal ArticleVorinostat for graft-versus-host disease prevention in pediatric and young adult patients with hematologic malignancies.
DOI:10.1172/jci.insight.210272 PMID: 42784255 -
Parnell N, Cao X, Beumer J, Braun T, Cui Y, Fisher G, Hou G, Holleran J, Churay T, Rozwadowski M, Heider L, Vander Lugt M, Kitko CL, Rahrig A, Peres E, Williams K, Tolano JA, Fabrizio V, Abusin G, Yanik G, Magenau J, Riwes M, Geer M, Anand S, Ghosh M, Pawarode A, Votruba KL, Reddy P, Choi S. JCI Insight, 2026 Sep 15;Journal ArticleVorinostat for Graft-Versus-Host Disease Prevention in Pediatric, Adolescent, and Young Adult Allogeneic Transplant
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Chen W, Fisher G, Cui Y, Baalawi H, Larson JL. Geriatric Nursing, 2026 Sep 1; 72:Journal ArticleFeasibility and effectiveness of a multimodal exercise intervention on physical activity and physical functions in low-income older adults
DOI:10.1016/j.gerinurse.2026.104160 -
Cui Y, Gau CC, Wang CW, Chen CB, Chung WH, Fisher GJ, Choi SW. Frontiers in Immunology, 2026 Jun 11; 17:Journal ArticleAdvances in graft-versus-host disease: emerging therapeutic strategies, biomarker discoveries, and innovative treatment approaches
DOI:10.3389/fimmu.2026.1816067 PMID: 42367753 -
Chen CB, Hung SI, Chang JWC, Yang CK, Ma DHK, Teng YC, Lu CW, Chen WT, Yang HY, Tsai CC, Wang CL, Chiang PH, Wu J, Tsai YW, Lu LY, Lin YYW, Hui RCY, Hsieh FM, Hsu CK, Lee CN, Chen YJ, Chen CC, Cui Y, Hsu HC, Chang YC, Chang CJ, Lin HC, Chang CJ, Lin YJ, Ku CL, Wang CW, Chung WH. Nature Communications, 2024 Dec 1; 15 (1):Journal ArticleImmune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade
DOI:10.1038/s41467-024-54180-7 PMID: 39737932 -
Cui Y, Shi M, Voorhees JJ, Zhou Y, Fisher GJ. Journal of Investigative Dermatology, 2023 Apr 18; 143 (5): s64Proceeding / Abstract / Poster374 Dermal fibroblasts from aged human skin express elevated levels of pro-inflammatory mediators
DOI:10.1016/j.jid.2023.03.379 -
Cui Y, Worthen C, Haas R, Grill S, Shi M, Tsoi LC, Nandakumar J, Voorhees J, Zhao Y, Fisher GJ. Journal of Investigative Dermatology, 2022 Jul 21; 142 (8): s24Proceeding / Abstract / Poster142 The phenotype of dermal fibroblasts in young vs. aged human skin: Adaptation to dermal extracellular matrix deterioration and cell autonomous responses
DOI:10.1016/j.jid.2022.05.148
