Santhosh A Upadhyaya, MBBS
Clinical Associate Professor of Pediatrics
Medical Director
C&W Pediatric Hematology/Oncology
Pediatric Cancer Infusion Center
Medical School
Email:
[email protected]
Phone:
Available to mentor
Santhosh A Upadhyaya, MBBS
Clinical Associate Professor
Manage Your Profile
About
My research focuses on advancing the clinical care of children with brain tumors, with a special interest in patients with atypical teratoid/rhabdoid
tumors (AT/RT) and ependymoma.
Qualifications
-
Pediatric Neuro-Oncology FellowSt. Jude Children's Research Hospital, Memphis, United States
2015 - 2016
Clinical Fellowship
-
Pediatric Hematology Oncology FellowC. S. Mott Children's Hospital, Ann Arbor, United States
2012 - 2015
Clinical Fellowship
-
Pediatric ResidentSt. John Hospital & Medical Center, Detroit, United States
2009 - 2012
Residency
-
Pediatric ResidentKasturba Medical College, Manipal, India
2001 - 2004
Residency
-
MBBSKasturba Medical College, Mangalore, India
1994 - 2000
Research Overview
My current and ongoing research is focused on translational studies and clinical trials for children with ependymoma and ATRT. Young children with brain tumors continue to have poor outcomes compared to those with other cancers in this age group. However, a better understanding of the biological and molecular aspects of pediatric brain tumors more recently are transforming the care of these children. I have analyzed the outcomes of treatment for ATRT and ependymoma in children, with special emphasis on combining traditional modes of therapy, such as surgery, chemotherapy, and radiation therapy, with molecularly targeted therapy. By identifying clinical and molecular risk factors associated with poor outcomes in these children, we can tailor therapy to improve outcomes in those at highest risk of treatment failures.
Recent Publications
-
Wang LD, Taravella Oill AM, Lindner SE, Stiller T, Blanchard MS, Mudunuri RV, Wu M, Hibbard JC, Egelston C, Sepulveda SM, Peter L, Kilpatrick JL, Stratman J, Mee ED, Chen DG, Oliveira G, Muñoz M, Wagner J, Dolatabadi AM, Nisis M, Shepphird JK, Sanchez G, Burmayan A, Langeliers K, Paul J, Villasenor Y, Wadden J, Adam T, de la Nava D, Natri HM, Oliver-Cervantes C, Feldman L, Shahani S, Aftabizadeh M, Forman SJ, Ressler J, Arvanitis L, Campbell KM, Cotter JA, Richman SA, D’Apuzzo M, Tamrazi B, Badie B, Wu CJ, Read JA, Upadhyaya SA, Koschmann C, Davidson TB, Banovich NE, Brown CE. 2026 Sep 3; medRxiv,PreprintLymphodepletion mitigates anti-CAR immunity in pediatric and young adult patients with recurrent or refractory brain tumors: clinical trial results
DOI:10.64898/2026.08.27.26361261 -
Lau BC, Ajaero DP, Hoff BA, Pearson A, Sajjakulnukit P, Wadden J, Adam T, Ji S, Green AL, Nabavizadeh A, Cao Y, Aryal M, Upadhyaya S, Franson A, Galban S, Venneti S, Federowicz B, Shapiro MA, Stuhlmiller TJ, Lyssiotis C, Galban CJ, Parmar HA, Ibrahim M, Koschmann C. Neuro Oncol, 2026 Jul 28;Journal ArticleEarly increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma.
DOI:10.1093/neuonc/noag164 -
Bagchi A, Kostecka A, Upadhyaya S, Billups C, Dhanda S, Smith KS, Soliman T, Baxter P, Bendel A, Aguilera D, Kilburn L, Crawford J, Partap S, Hanzlik E, Tran Q, Breuer A, Qi W, Lu C, Singh A, Richardson M, Soans E, Klimo P, Zhou X, Orr B, Merchant T, Robinson G, Onar-Thomas A, Northcott P, Gajjar A. Neuro-Oncology Pediatrics, 2026 Jun 25; 2 (Supplement_1): wuag026.513Journal ArticleID #1131 Predicting Early Tumor Progression in Patients with Atypical Teratoid/Rhabdoid Tumor with Longitudinal CSF Liquid Biopsies: A Report from Phase 2 Study (SJATRT) stratum B1.
DOI:10.1093/neuped/wuag026.513 -
Wang L, Oill AT, Lindner S, Stiller T, Blanchard MS, Mudunuri R, Kilpatrick J, Stratman J, Hibbard J, Sepulveda S, Peter L, Chen D, Munoz M, Wagner J, Nisis M, Dolatabadi A, Gomez G, Natri H, Forman S, Ressler J, Arvanitis L, Campbell K, Cotter J, Richman S, D’Apuzzo M, Tamrazi B, Badie B, Read J, Upadhyaya S, Koschmann C, Davidson T, Banovich N, Brown C. Neuro-Oncology Pediatrics, 2026 Jun 25; 2 (Supplement_1): wuag026.186Journal ArticleID #510 Intraventricular delivery of IL13Rα2-targeting CAR T cells in pediatric and young adult patients with recurrent or refractory central nervous system tumors: results of a Phase 1 trial
DOI:10.1093/neuped/wuag026.186 -
Bagchi A, Upadhyaya S, Ashford JM, Billups C, Singh A, Soans E, Klimo P, Merchant TE, Robinson G, Thomas AO, Gajjar A, Conklin H. Neuro-Oncology Pediatrics, 2026 Jun 25; 2 (Supplement_1): wuag026.433Journal ArticleID #991 Title: Neurocognitive and Quality of Life Outcomes of Patients with Atypical Teratoid/Rhabdoid Tumor (AT/RT)- A Report from Phase 2 Study (SJATRT) Strata B & C
DOI:10.1093/neuped/wuag026.433 -
Schwark K, Wink K, De Cola A, Miclea M, Patel T, Kong S, Stanczak A, Doherty R, Pearson A, Murthy B, Lau B, Cartaxo RT, Messinger D, Ji S, Wadden J, Clausen M, de la Nava D, Goethe P, Momen F, Adam T, Hutchinson A, Niculcea M, Serhan H, Merrill NM, Edmonds A, Mayr L, Neyazi S, Muñoz DP, Hwang Y, Nuechterlein NK, Fernández EC, Califano A, Pavisic J, Garton H, Rao R, Upadhyaya SA, Skrypek M, Bendel AE, Lobbous M, Klawinski D, Merajver SD, Koptyra MP, Resnick AC, Nazarian J, Venneti S, Waszak SM, Chavez L, Gojo J, Filbin MG, Beck A, Pathania M, Coppe J-PF, Koschmann C. 2026 Jun 24;PreprintCombinatorial Targeting of Avapritinib-Driven MAP Kinase Activation in High-Grade Glioma.
DOI:10.21203/rs.3.rs-9974885/v1 PMID: 42396537 -
Siada R, Banerjee K, Malhotra P, Ibrahim M, Moreira DC, Prensner JR, Upadhyaya SA. Cancers, 2026 Apr 8; 18 (7): 1171Journal ArticlePediatric Spinal Atypical Teratoid Rhabdoid Tumor: Recent Advances in Biology and Management Options
DOI:10.3390/cancers18071171 -
Malhotra V, Lieberman AP, Prensner JR, Quinonez SC, Muraszko K, Marupudi NI, Upadhyaya SA. Pediatr Blood Cancer, 2026 Mar 15; e70215Journal ArticleFGFR1:TACC1-Fused Pilocytic Astrocytoma in a Child With Muenke Syndrome: A Case Report.
DOI:10.1002/1545-5017.70215 PMID: 41834352
