2800 Plymouth Rd
Ann Arbor, MI 48109
Available to mentor
Changyang Linghu is an assistant professor in the Department of Cell and Developmental Biology, member of the Single Cell Spatial Analysis Program and the Michigan Neuroscience Institute, affiliate faculty in the Department of Biomedical Engineering, and leader of the Spatial Biodynamics Lab (spatialbiodynamics.org) at the University of Michigan. His research focuses on developing and applying enabling technologies for scalable and multiplexable interrogation of cell physiology in vivo. Before joining U-M, he completed his PhD and postdoctoral training at the Massachusetts Institute of Technology. Dr. Linghu is the recipient of the Biological Sciences Scholar (BSSP), MIT Spot Award, MIT Technology Review 35 Innovators Under 35 (TR35) China, Bioengineering Rising Star Speaker by Princeton University, J. Douglas Tan Postdoctoral Fellow, McGovern Graduate Fellow, and MIT Presidential Fellow.
The Spatial Biodynamics Lab are at the intersection of the Medical School, Neuroscience Institute, Biosciences Initiative, and Biomedical Engineering at the University of Michigan, and provide a unique and world's top interdisciplinary research and training environment. The Spatial Biodynamics Lab is on a mission to unravel emergent properties of cell populations that drive essential mammalian functions, via scalable and multiplexable interrogation of cell physiology in vivo.
Spatial Biodynamics Lab Google Scholar twitter
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Postdoctoral FellowMassachusetts Institute of Technology, McGovern Institute for Brain Research, 2022
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Ph.D.Massachusetts Institute of Technology, Cambridge, 2019
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M.S.Massachusetts Institute of Technology, Cambridge, 2016
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B.E.Tsinghua University, Beijing, 2013
Biotechnology, Neuroscience, Biosensors and Bioactuators, Biomedical and Optical Imaging, Protein Engineering, Signaling Network Dynamics, Gene Expression Histories, Mechanobiology
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Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES. Nat Biotechnol, 2023 May; 41 (5): 640 - 651.Journal ArticleRecording of cellular physiological histories along optically readable self-assembling protein chains.
DOI:10.1038/s41587-022-01586-7 PMID: 36593405 -
Linghu C, Chen I-W, Tanese D, Zampini V, Shemesh OA. Methods Mol Biol, 2022 2501: 229 - 257.ChapterSingle-Cell Resolution Optogenetics Via Expression of Soma-Targeted Rhodopsins.
DOI:10.1007/978-1-0716-2329-9_11 PMID: 35857231 -
Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao C-C, Yu C-CJ, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES. Cell, 2020 Dec 10; 183 (6): 1682 - 1698.e24.Journal ArticleSpatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics.
DOI:10.1016/j.cell.2020.10.035 PMID: 33232692 -
Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu C-CJ, Tseng H-A, Bensussen S, Narayan S, Yang C-T, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon Y-G, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. Neuron, 2020 Aug 5; 107 (3): 470 - 486.e11.Journal ArticlePrecision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator.
DOI:10.1016/j.neuron.2020.05.029 PMID: 32592656 -
Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. Nat Commun, 2024 May 27; 15 (1): 4480Journal ArticlePixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
DOI:10.1038/s41467-024-48765-5 PMID: 38802338 -
Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. 2024 May 2;PreprintPixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
DOI:10.1101/2023.06.27.546748 PMID: 37425952 -
Bando Y, Pillai R, Kajita A, Hakeem FA, Quemener Y, Tseng H-A, Piatkevich KD, Linghu C, Han X, Boyden ES. 2024 Mar 25; arXiv,PreprintReal-time Neuron Segmentation for Voltage Imaging
DOI:10.48550/arxiv.2403.16438 -
Bando Y, Pillai R, Kajita A, Hakeem FA, Quemener Y, Tseng HA, Piatkevich KD, Linghu C, Han X, Boyden ES. Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023, 2023 Jan 1; 813 - 818.Proceeding / Abstract / PosterReal-time Neuron Segmentation for Voltage Imaging
DOI:10.1109/BIBM58861.2023.10385929