Changyang Linghu
Assistant Professor
Michigan Neuroscience Institute
2800 Plymouth Rd
Ann Arbor, MI 48109
[email protected]

Available to mentor

Changyang Linghu
Assistant Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Changyang Linghu is an assistant professor in the Department of Cell and Developmental Biology, member of the Single Cell Spatial Analysis Program and the Michigan Neuroscience Institute, affiliate faculty in the Department of Biomedical Engineering, and leader of the Spatial Biodynamics Lab (spatialbiodynamics.org) at the University of Michigan. His research focuses on developing and applying enabling technologies for scalable and multiplexable interrogation of cell physiology in vivo. Before joining U-M, he completed his PhD and postdoctoral training at the Massachusetts Institute of Technology. Dr. Linghu is the recipient of the Biological Sciences Scholar (BSSP), MIT Spot Award, MIT Technology Review 35 Innovators Under 35 (TR35) China, Bioengineering Rising Star Speaker by Princeton University, J. Douglas Tan Postdoctoral Fellow, McGovern Graduate Fellow, and MIT Presidential Fellow.

    The Spatial Biodynamics Lab are at the intersection of the Medical School, Neuroscience Institute, Biosciences Initiative, and Biomedical Engineering at the University of Michigan, and provide a unique and world's top interdisciplinary research and training environment. The Spatial Biodynamics Lab is on a mission to unravel emergent properties of cell populations that drive essential mammalian functions, via scalable and multiplexable interrogation of cell physiology in vivo.

    Links
    • Spatial Biodynamics Lab
    • Google Scholar
    • twitter
    Qualifications
    • Postdoctoral Fellow
      Massachusetts Institute of Technology, McGovern Institute for Brain Research, 2022
    • Ph.D.
      Massachusetts Institute of Technology, Cambridge, 2019
    • M.S.
      Massachusetts Institute of Technology, Cambridge, 2016
    • B.E.
      Tsinghua University, Beijing, 2013
    Research Overview

    Biotechnology, Neuroscience, Biosensors and Bioactuators, Biomedical and Optical Imaging, Protein Engineering, Signaling Network Dynamics, Gene Expression Histories, Mechanobiology

    Recent Publications See All Publications
    • Journal Article
      Recording of cellular physiological histories along optically readable self-assembling protein chains.
      Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES. Nat Biotechnol, 2023 May; 41 (5): 640 - 651. DOI:10.1038/s41587-022-01586-7
      PMID: 36593405
    • Chapter
      Single-Cell Resolution Optogenetics Via Expression of Soma-Targeted Rhodopsins.
      Linghu C, Chen I-W, Tanese D, Zampini V, Shemesh OA. Methods Mol Biol, 2022 2501: 229 - 257. DOI:10.1007/978-1-0716-2329-9_11
      PMID: 35857231
    • Journal Article
      Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics.
      Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao C-C, Yu C-CJ, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES. Cell, 2020 Dec 10; 183 (6): 1682 - 1698.e24. DOI:10.1016/j.cell.2020.10.035
      PMID: 33232692
    • Journal Article
      Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator.
      Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu C-CJ, Tseng H-A, Bensussen S, Narayan S, Yang C-T, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon Y-G, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. Neuron, 2020 Aug 5; 107 (3): 470 - 486.e11. DOI:10.1016/j.neuron.2020.05.029
      PMID: 32592656
    • Journal Article
      Pixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
      Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. Nat Commun, 2024 May 27; 15 (1): 4480 DOI:10.1038/s41467-024-48765-5
      PMID: 38802338
    • Preprint
      Pixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
      Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. 2024 May 2; DOI:10.1101/2023.06.27.546748
      PMID: 37425952
    • Preprint
      Real-time Neuron Segmentation for Voltage Imaging
      Bando Y, Pillai R, Kajita A, Hakeem FA, Quemener Y, Tseng H-A, Piatkevich KD, Linghu C, Han X, Boyden ES. 2024 Mar 25; arXiv, DOI:10.48550/arxiv.2403.16438
    • Proceeding / Abstract / Poster
      Real-time Neuron Segmentation for Voltage Imaging
      Bando Y, Pillai R, Kajita A, Hakeem FA, Quemener Y, Tseng HA, Piatkevich KD, Linghu C, Han X, Boyden ES. Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023, 2023 Jan 1; 813 - 818. DOI:10.1109/BIBM58861.2023.10385929
    Featured News & Stories
    News Release
    NIH High-Risk, High-Reward program awards three U-M Medical School investigators
    Three U-M investigators—Changyang Linghu, Longhua Guo and Sundeep Kalantry—have been acknowledged by the National Institutes of Health’s (NIH) prestigious High-Risk, High-Reward Research program.
    Department News
    Congratulations to Changyang Linghu!
    Changyang has been chosen as one of MIT Technology Review’s 2024 Innovators Under 35.
    Department News
    New Publication by Changyang Linghu
    "Recording of cellular physiological histories along optically readable self-assembling protein chains" has been published in Nature Biotechnology!