2800 Plymouth Rd
Ann Arbor, MI 48109
Available to mentor
Changyang Linghu is an assistant professor in the Department of Cell and Developmental Biology, member of the Single Cell Spatial Analysis Program and the Michigan Neuroscience Institute, and affiliate faculty in the Department of Biomedical Engineering at the University of Michigan, Ann Arbor. Before joining U-M, he obtained a Bachelor of Engineering from Tsinghua University and completed his Ph.D. at Massachusetts Institute of Technology working with Dr. Ed Boyden. His lab (Spatial Biodynamics Lab: spatialbiodynamics.org) is on a mission to unravel emergent properties of cell populations that drive essential brain functions, via scalable and multiplexable interrogation of cell physiology in vivo.
Dr. Linghu is the recipient of the NIH Director's New Innovator Award (2024), MIT Technology Review's Global 35 Innovators Under 35 (TR35) (2024), Glenn and AFAR Junior Faculty Grant (2024), Chan Zuckerberg Initiative Collaborative Pairs Pilot Project Award (2024), Whitehall Foundation Three-Year Research Grant (2024), GenScript Life Science Research Grant (2024), Bioengineering in Brain Cancer Challenge Seed Fund Award from UMich (2024), Spatial Analytics of Cancer Challenge Seed Fund Award from UMich (2023), Biological Sciences Scholar (BSSP) from UMich (2022), MIT Spot Award (for community service) (2022), MIT Technology Review 35 Innovators Under 35 China (TR35 China) (2021), Bioengineering Rising Star Speaker from Princeton University (2021), J. Douglas Tan Postdoctoral Fellow (2020), McGovern Graduate Fellow (2018), and MIT Presidential Fellow (supported by Irwin Mark Jacobs and Joan Klein Jacobs) (2013).
The Spatial Biodynamics Lab is at the intersection of the Medical School, Neuroscience Institute, Biosciences Initiative, and Biomedical Engineering at the University of Michigan, and provides a unique and world's top interdisciplinary research and training environment.
Spatial Biodynamics Lab Google Scholar twitter
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Postdoctoral FellowMassachusetts Institute of Technology, McGovern Institute for Brain Research, 2022
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Ph.D.Massachusetts Institute of Technology, 2019
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M.S.Massachusetts Institute of Technology, 2016
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B.E.Tsinghua University, 2013
Biotechnology, Neuroscience, Biosensors and Bioactuators, Biomedical and Optical Imaging, Protein Engineering, Signaling Network Dynamics, Gene Expression Histories, Mechanobiology
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Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES. Nature Biotechnology, 2023 May 1; 41 (5): 640 - 651.Journal ArticleRecording of cellular physiological histories along optically readable self-assembling protein chains
DOI:10.1038/s41587-022-01586-7 PMID: 36593405 -
Linghu C, Chen IW, Tanese D, Zampini V, Shemesh OA. 2022 Jan 1; 2501: Methods in Molecular Biology, 229 - 257.ChapterSingle-Cell Resolution Optogenetics Via Expression of Soma-Targeted Rhodopsins
DOI:10.1007/978-1-0716-2329-9_11 PMID: 35857231 -
Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao CC, Yu CC, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES. Cell, 2020 Dec 10; 183 (6): 1682 - 1698.e24.Journal ArticleSpatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
DOI:10.1016/j.cell.2020.10.035 PMID: 33232692 -
Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CC, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. Neuron, 2020 Aug 5; 107 (3): 470 - 486.e11.Journal ArticlePrecision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
DOI:10.1016/j.neuron.2020.05.029 PMID: 32592656 -
Zheng L, Yan Y, Zhou B, Lim J, Shi D, An B, Ko B, Klyder E, Pitchiaya S, Cai DJ, Boyden ES, Wei D, Liò P, Linghu C. 2025 May 15; bioRxiv,PreprintMultiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes
DOI:10.1101/2025.05.10.653182 -
Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. Nature Communications, 2024 Dec 1; 15 (1):Journal ArticlePixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy
DOI:10.1038/s41467-024-48765-5 PMID: 38802338 -
Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. 2024 May 2;PreprintPixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
DOI:10.1101/2023.06.27.546748 PMID: 37425952 -
Bando Y, Pillai R, Kajita A, Hakeem FA, Quemener Y, Tseng H-A, Piatkevich KD, Linghu C, Han X, Boyden ES. 2024 Mar 27; arXiv,PreprintReal-time Neuron Segmentation for Voltage Imaging
DOI:10.48550/arxiv.2403.16438
