Tools and Technology Seminar: Jim Clauwaert

"Discovering coding sequences using Transformer networks"

Tool Link: https://github.com/TRISTAN-ORF/TRISTANAbstract

Abstract

The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Accurate delineation of RNA translation variation represents a significant challenge due to the complexity of the process and technical limitations. We explore the use of a transformer-based networks to leverage the analysis of transcript sequences and ribosome profiling data. I will detail the implementation of this model and how it is currently used in ongoing studies to discover translation products.