What I'm Reading in APS Research: April 2026

April 13, 2026

Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome

A new study from Johns Hopkins University sheds light on why some people with antiphospholipid syndrome (APS) develop the rare but life-threatening complication known as catastrophic APS (CAPS). CAPS is marked by overwhelming inflammation, and prior studies suggest that drugs targeting the “complement system” may help in some cases.

In this work, researchers focused on a protein called CR1, which normally helps “turn off” complement-driven inflammation by clearing activated proteins from the bloodstream. They found that patients with CAPS had much lower levels of CR1 on their blood cells compared to other APS patients.

This finding suggests that in CAPS, the body may lose an important brake on inflammation, allowing the complement system to spiral out of control. Looking ahead, CR1 could help doctors better identify patients at risk and point toward more targeted treatment strategies. This is an exciting area to watch!

Cardiovascular risk factor control in antiphospholipid syndrome, and differences between primary and systemic lupus erythematosus-related antiphospholipid syndrome (SURF-SLE and APS project): a cross-sectional study of 1003 individuals from 11 countries

In a large international study spanning 11 countries, researchers examined cardiovascular health in more than 1,000 people with APS. The results were striking. Many patients had risk factors that were not well controlled. 41% had elevated blood pressure, 34% had high cholesterol, 32% had obesity, and 19% were current smokers.

The message is simple but important: managing APS is only part of the picture. Traditional cardiovascular risk factors, including blood pressure, cholesterol, weight, and smoking, also play a major role in long-term health. For patients and doctors alike, this is a reminder to take a comprehensive approach. Small, consistent steps to improve these factors can make a meaningful difference over time.

In This Story

Jason Scott Knight, MD, PhD

Professor

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