Scott F Leiser
Associate Professor of Molecular and Integrative Physiology
Associate Professor of Internal Medicine and Associate Director Academic Program, Molecular and Integrative Physiology, Medical School
109 Zina Pitcher Place, BSRB 3027
Ann Arbor, MI 48109
[email protected]
Ann Arbor, MI 48109
Available to mentor
Scott F Leiser
Associate Professor
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Qualifications
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Postdoctoral Research FellowUniversity of Washington, Seattle, WA, USA
2009 - 2015
Center Memberships
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Research in the Leiser lab is focused on the molecular mechanisms of aging, specifically how stress and metabolism affect the aging process. They utilize a translational, multi-system approach, including the nematode Caenorhabditis elegans, multiple mammalian in vitro tissue culture models, and mouse models, toward achieving a long-term goal of developing treatments to prevent age-related diseases and both improve and extend human lifespan. With this model in mind, they study how environmental perception, metabolism and the flavin-containing monooxygenase gene family each regulate healthspan and longevity.
Links
Leiser Lab
Recent Publications
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Choi HS, Bhat A, Howington MB, Schaller ML, Cox RL, Huang S, Beydoun S, Miller HA, Tuckowski AM, Mecano J, Dean ES, Jensen L, Beard DA, Evans CR, Leiser SF. Nature Communications, 2023 Dec 1; 14 (1):Journal ArticleFMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans
DOI:10.1038/s41467-023-36181-0 PMID: 36732543 -
Miller HA, Huang S, Dean ES, Schaller M, Tuckowski A, Munneke A, Beydoun S, Pletcher SP, Leiser SF. Nature Communications, 2022 Jan 1; 13:Journal ArticleSerotonin and dopamine modulate aging in response to food odor and availability.
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Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF. Communications Biology, 2021 Dec 1; 4 (1):Journal ArticleAn alternative food source for metabolism and longevity studies in Caenorhabditis elegans
DOI:10.1038/s42003-021-01764-4 PMID: 33637830 -
Huang S, Howington MB, Dobry CJ, Evans CR, Leiser SF. Frontiers in Cell and Developmental Biology, 2021 Feb 12; 9:Journal ArticleFlavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism
DOI:10.3389/fcell.2021.630188 -
Miller HA, Dean ES, Pletcher SD, Leiser SF. Elife, 2020 Dec 1; 9: 1 - 28.Journal ArticleCell non-autonomous regulation of health and longevity
DOI:10.7554/ELIFE.62659 PMID: 33300870 -
Rossner R, Kaeberlein M, Leiser SF. Journal of Biological Chemistry, 2017 Jul 7; 292 (27): 11138 - 11146.Journal ArticleFlavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes
DOI:10.1074/jbc.R117.779678 PMID: 28515321 -
Miller H, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Aging Cell, 2017 Jan 1; 16 (6): 1425 - 1429.Journal ArticleGenetic interaction with temperature is an important determinant of nematode longevity.
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Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M. Science, 2015 Dec 11; 350 (6266): 1375 - 1377.Journal ArticleCell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span
DOI:10.1126/science.aac9257 PMID: 26586189
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