Peter K Todd, MD, PhD
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About
I am a physician scientist who studies inherited neurological disorders and a board-certified neurologist with specialty training in Movement Disorders and Neurogenetics. My lab studies nucleotide repeat expansion disorders, including work on Fragile X-associated disorders, C9orf72-associated ALS and Frontotemporal Dementia, Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS), Huntington's Disease and Myotonic Dystrophy. We use drosophila, mice and cell based (including human inducible pluripotent stem cells) model systems to explore the mechanisms underlying these diseases with a goal of developing novel therapeutics. We also explore novel means by which repetitive elements influence native neuronal function and contribute to common neurological conditions.
Clinically, I see patients with inherited neurodegenerative disorders, including Parkinson's Disease, Dementia, and Ataxia. I direct both the University of Michigan Fragile X Clinic and our Multidisciplinary Ataxia Clinic while also seeing patients and teaching residents and medical students at the Ann Arbor VA Medical Center. Administratively, I serve as Associate Chair for Research in the Department of Neurology at Michigan where I play active roles in faculty recruitment and retention, promotion, clinical trial infrastructure and help guide our department’s overall research strategy.
Links
https://sites.google.com/site/toddlabmichigan/todd-lab
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberAI and Digital Health Innovation
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Center MemberFrankel Institute for Heart and Brain Health
Recent Publications
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Tang Z, Ovunc SS, Iwase R, Mehinovic E, Thomas S, Ulibarri J, Li Z, Baldridge D, Cruchaga C, Liu M, Johnson M, Milbrandt J, Callaghan B, PNRR Study Group , Höke A, Todd PK, Jin SC. Ann Neurol, 2026 Apr 11;Journal ArticleHomozygous RFC1 AAGGG Repeat Expansions Are Common in Idiopathic Peripheral Neuropathy.
DOI:10.1002/ana.78226 PMID: 41964406 -
Li C, Daw JA, Pittman SK, Maltby CJ, Sakurai H, Todd PK, Weihl CC. Acta Neuropathol Commun, 2026 Mar 6;Journal ArticleTranslation of expanded CGG repeats in LRP12 associated oculopharyngodistal myopathy.
DOI:10.1186/s40478-026-02272-4 PMID: 41792844 -
He D, Yano S, Li S, Gary A, Mook A, Lu H, Srinivasan S, Todd P, Shakkottai V, Das S. Genetics in Medicine Open, 2026 Mar 7; 4: 104134Journal ArticleP644: Spinocerebellar ataxia type 50: Recurrent p.(Gly389Arg) variant highlights a shared molecular mechanism and expands the clinical spectrum
DOI:10.1016/j.gimo.2026.104134 -
Krans A, Albertson RM, Maltby C, Todd PK. 2025 Sep 7; bioRxiv,PreprintComparative analysis of RAN translation from CAG repeats within the Huntingtin coding sequence
DOI:10.1101/2025.09.02.673827 -
Miller SL, Green KM, Crone B, Switzenberg JA, Tank EMH, Krans A, Jansen-West K, Wieland CM, Ji EW, Petrucelli L, Barmada SJ, Boyle AP, Todd PK. Proceedings of the National Academy of Sciences of the United States of America, 2025 Aug 12; 122 (32):Journal ArticleCryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation
DOI:10.1073/pnas.2507334122 PMID: 40758885 -
Tang Z, Ovunc SS, Mehinovic E, Thomas S, Ulibarri J, Li Z, Baldridge D, Cruchaga C, Johnson M, Milbrandt J, Callaghan B, PNRR Study Group , Höke A, Todd PK, Jin SC. 2025 Apr 23;PreprintHeterozygous and Homozygous RFC1 AAGGG Repeat Expansions are Common in Idiopathic Peripheral Neuropathy.
DOI:10.1101/2025.04.18.25325809 PMID: 40313272 -
Hall D, Krans A, Killinger B, Todd P. Neurology, 2025 Apr 9; 104 (7_Supplement_1):Journal ArticleFragile X-associated Tremor/Ataxia Syndrome: A Feasibility Study of Measurement of Skin FMRpolyG (P6-5.011)
DOI:10.1212/wnl.0000000000211475 -
Albertson R, Chen A, Todd P. 2025 Apr 29;Proceeding / Abstract / PosterThe Temporal Landscape of Age-Related Genetically Triggered Neurodegeneration