Peter K Todd, MD, PhD

profile-peter-todd-2014
Chester and Anne Alecks Sackett Endowed Professor
Professor of Neurology
Associate Chair for Research
Department of Neurology
Medical Director, Neurology
Professor of Human Genetics
Medical School
[email protected]
Available to mentor
Peter K Todd, MD, PhD
profile-peter-todd-2014
Professor
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  • About

    I am a physician scientist who studies inherited neurological disorders and a board-certified neurologist with specialty training in Movement Disorders and Neurogenetics. My lab studies nucleotide repeat expansion disorders, including work on Fragile X-associated disorders, C9orf72-associated ALS and Frontotemporal Dementia, Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS), Huntington's Disease and Myotonic Dystrophy. We use drosophila, mice and cell based (including human inducible pluripotent stem cells) model systems to explore the mechanisms underlying these diseases with a goal of developing novel therapeutics. We also explore novel means by which repetitive elements influence native neuronal function and contribute to common neurological conditions.

    Clinically, I see patients with inherited neurodegenerative disorders, including Parkinson's Disease, Dementia, and Ataxia. I direct both the University of Michigan Fragile X Clinic and our Multidisciplinary Ataxia Clinic while also seeing patients and teaching residents and medical students at the Ann Arbor VA Medical Center. Administratively, I serve as Associate Chair for Research in the Department of Neurology at Michigan where I play active roles in faculty recruitment and retention, promotion, clinical trial infrastructure and help guide our department’s overall research strategy.

    Links

    • https://sites.google.com/site/toddlabmichigan/todd-lab

    Center Memberships

    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Frankel Institute for Heart and Brain Health

    Recent Publications

    See All Publications
    • Journal Article
      Homozygous RFC1 AAGGG Repeat Expansions Are Common in Idiopathic Peripheral Neuropathy.
      Tang Z, Ovunc SS, Iwase R, Mehinovic E, Thomas S, Ulibarri J, Li Z, Baldridge D, Cruchaga C, Liu M, Johnson M, Milbrandt J, Callaghan B, PNRR Study Group , Höke A, Todd PK, Jin SC. Ann Neurol, 2026 Apr 11; DOI:10.1002/ana.78226
      PMID: 41964406
    • Journal Article
      Translation of expanded CGG repeats in LRP12 associated oculopharyngodistal myopathy.
      Li C, Daw JA, Pittman SK, Maltby CJ, Sakurai H, Todd PK, Weihl CC. Acta Neuropathol Commun, 2026 Mar 6; DOI:10.1186/s40478-026-02272-4
      PMID: 41792844
    • Journal Article
      P644: Spinocerebellar ataxia type 50: Recurrent p.(Gly389Arg) variant highlights a shared molecular mechanism and expands the clinical spectrum
      He D, Yano S, Li S, Gary A, Mook A, Lu H, Srinivasan S, Todd P, Shakkottai V, Das S. Genetics in Medicine Open, 2026 Mar 7; 4: 104134 DOI:10.1016/j.gimo.2026.104134
    • Preprint
      Comparative analysis of RAN translation from CAG repeats within the Huntingtin coding sequence
      Krans A, Albertson RM, Maltby C, Todd PK. 2025 Sep 7; bioRxiv, DOI:10.1101/2025.09.02.673827
    • Journal Article
      Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation
      Miller SL, Green KM, Crone B, Switzenberg JA, Tank EMH, Krans A, Jansen-West K, Wieland CM, Ji EW, Petrucelli L, Barmada SJ, Boyle AP, Todd PK. Proceedings of the National Academy of Sciences of the United States of America, 2025 Aug 12; 122 (32): DOI:10.1073/pnas.2507334122
      PMID: 40758885
    • Preprint
      Heterozygous and Homozygous RFC1 AAGGG Repeat Expansions are Common in Idiopathic Peripheral Neuropathy.
      Tang Z, Ovunc SS, Mehinovic E, Thomas S, Ulibarri J, Li Z, Baldridge D, Cruchaga C, Johnson M, Milbrandt J, Callaghan B, PNRR Study Group , Höke A, Todd PK, Jin SC. 2025 Apr 23; DOI:10.1101/2025.04.18.25325809
      PMID: 40313272
    • Journal Article
      Fragile X-associated Tremor/Ataxia Syndrome: A Feasibility Study of Measurement of Skin FMRpolyG (P6-5.011)
      Hall D, Krans A, Killinger B, Todd P. Neurology, 2025 Apr 9; 104 (7_Supplement_1): DOI:10.1212/wnl.0000000000211475
    • Proceeding / Abstract / Poster
      The Temporal Landscape of Age-Related Genetically Triggered Neurodegeneration
      Albertson R, Chen A, Todd P. 2025 Apr 29;

    Featured News & Stories

    Department News

    Highlighted Publications - February 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - January 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - December 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - September 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - August 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.