Miriam H Meisler

 portrait of Miriam H Meisler
Myron Levine Distinguished University Professor of Human Genetics
Professor of Human Genetics
Professor of Neurology
Medical School
[email protected]
Available to mentor
Miriam H Meisler
portrait of Miriam H Meisler
Professor
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    • Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design

    Recent Publications

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    • Journal Article
      Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model
      Reever CM, Boscia AR, Deutsch TC, Patel MP, Miralles RM, Kittur S, Fleischel EJ, Buo AM, Yorek MS, Meisler MH, Farber CR, Patel MK. Journal of Clinical Investigation, 2026 Feb 2; 136 (3): DOI:10.1172/JCI196402
      PMID: 41623181
    • Preprint
      Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy
      Reever CM, Boscia AR, Deutsch TCJ, Patel MP, Miralles RM, Kittur S, Fleischel EJ, Buo AML, Yorek MS, Meisler MH, Farber CR, Patel MK. 2025 Apr 12; bioRxiv, DOI:10.1101/2025.04.09.647983
    • Journal Article
      Protein family FAM241 in human and mouse
      Doctrove Q, Park Y, Calame DG, Kitzman J, Lenk GM, Meisler MH. Mammalian Genome, 2025 Mar 1; 36 (1): 83 - 92. DOI:10.1007/s00335-024-10096-7
      PMID: 39715844
    • Journal Article
      Allele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects against Seizures and Lethality in a Murine Model
      Yu W, Hill SF, Huang Y, Zhu L, Demetriou Y, Ziobro J, Reger F, Jia X, Mattis J, Meisler MH. Annals of Neurology, 2024 Nov 1; 96 (5): 958 - 969. DOI:10.1002/ana.27053
      PMID: 39158034
    • Journal Article
      Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy
      Yu W, Hill S, Zhu L, Demetriou Y, Reger F, Mattis J, Meisler M. Neurobiology of Disease, 2024 Jul 8; 199:
    • Journal Article
      A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants
      Meyer-Schuman R, Cale AR, Pierluissi JA, Jonatzke KE, Park YN, Lenk GM, Oprescu SN, Grachtchouk MA, Dlugosz AA, Beg AA, Meisler MH, Antonellis A. Human Genetics and Genomics Advances, 2024 Jul 18; 5 (3): DOI:10.1016/j.xhgg.2024.100324
      PMID: 38956874
    • Chapter
      Sodium Channelopathies in Human and Animal Models of Epilepsy and Neurodevelopmental Disorders
      Yamakawa K, Meisler MH, Isom LL. 2024 Jul 29; Jasper's Basic Mechanisms of the Epilepsies, 881 - 920. DOI:10.1093/med/9780197549469.003.0044
    • Journal Article
      Biallelic loss-of-function variants of SLC12A9 cause lysosome dysfunction and a syndromic neurodevelopmental disorder
      Accogli A, Park YN, Lenk GM, Severino M, Scala M, Denecke J, Hempel M, Lessel D, Kortüm F, Salpietro V, de Marco P, Guerrisi S, Torella A, Nigro V, Srour M, Turro E, Labarque V, Freson K, Piatelli G, Capra V, Kitzman JO, Meisler MH. Genetics in Medicine, 2024 May 1; 26 (5): DOI:10.1016/j.gim.2024.101097
      PMID: 38334070

    Featured News & Stories
    Department News

    Highlighted Publications - April 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - January 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - October 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - September 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - August 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - July 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.