Gabriel Corfas, PhD
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About
Gabriel Corfas obtained an MSc in Biological Sciences from the University of Buenos Aires and a doctorate in Neurobiology from the Weizmann Institute of Science. During his postdoctoral training, first at Washington University in St. Louis, MO, and then at Harvard Medical School, he contributed to identifying and cloning the trophic factor Neuregulin 1 and its mechanism of action. In 1996 he obtained a faculty position at Harvard Medical School and Boston Children’s Hospital (BCH), eventually becoming a Professor of Neurology and Otolaryngology and director of basic research in Otolaryngology at BCH.
Since 2014 Corfas has been the Director of the Kresge Hearing Research Institute and associate chair for research for the Department of Otolaryngology and Head and Neck Surgery at the University of Michigan in Ann Arbor.
Dr. Corfas’s research focuses on the cellular and molecular mechanisms of nervous system development, plasticity, degeneration, and regeneration. Current efforts are devoted to identifying the mechanisms of noise-induced and age-related hearing loss and developing therapies for these prevalent disorders. The lab also investigates how social isolation alters brain structure and function.
For his work, Dr. Corfas has received many honors and awards, including a Klingenstein Fellowship in the Neurosciences, an Alfred P. Sloan Research Fellowship, an award from the EJLB Foundation, a Young and an Independent Investigator Award from NARSAD, as well as being elected secretary and treasurer of the Association for Research in Otolaryngology and a fellow of the American Association for the Advancement of Science.
Center Memberships
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Center MemberKresge Hearing Research Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Molecular and cellular mechanisms of brain development and plasticity
Cellular and molecular mechanisms of inner ear development and function
Hearing loss and Balance disorders
Neuron-glia interactions
Mechanisms of peripheral neuropathies
Development of drugs for peripheral neuropathies
Recent Publications
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Tripathy S, Budak M, Maddox R, Mehta AH, Roberts MT, Corfas G, Booth V, Zochowski M. 2026 Feb 4;PreprintImpacts of heminode disruption on auditory processing of noisy sound stimuli.
DOI:10.64898/2026.02.02.703242 PMID: 41676699 -
Radyk MD, Nelson BS, Ruckert MT, Halbrook CJ, Shan M, Alektiar JM, Lavoie BL, Salvatore L, Yan W, Perricone MD, Buscher K, Wood A, Hong HS, Sajjakulnukit P, Zhang L, Corfas G, Bednar F, Frankel TL, Pasca di Magliano M, Colacino JA, Shah YM, Crawford HC, Lyssiotis CA. Nature Metabolism, 2026 Jan 1;Journal ArticleNADPH-producing enzymes restrict the formation of pancreatic precancerous lesions
DOI:10.1038/s42255-026-01496-x PMID: 41922743 -
Komur FN, Genc B, Cassinotti LR, Corfas G, Ciprut A, Yumusakhuylu AC. Frontiers in Integrative Neuroscience, 2026 Jan 1; 19:Journal ArticleNoise-induced vestibular dysfunction in rats: longitudinal assessment using cVEMP and behavioral testing after low-frequency acoustic trauma
DOI:10.3389/fnint.2025.1677019 -
Radyk M, Nelson B, Halbrook C, Shan M, Ruckert MT, Alektiar J, Lavoie B, Hong H, Wood A, Salvatore L, Sajjakulnukit P, Yan W, Perricone M, Zhang L, Corfas G, Bednar F, Colacino J, Frankel T, Pasca di Magliano M, Shah Y, Crawford H, Lyssiotis C. Cancer Research, 2025 Dec 6; 85 (23_Supplement): pr003 - pr003.Journal ArticleAbstract PR003: NADPH-producing enzymes restrict precancer progression in the pancreas
DOI:10.1158/1538-7445.canevol25-pr003 -
Zhou X, Chen J, Patel JS, Ran W, Li Y, Van RS, Ibrahim MMH, Zhao C, Gao Y, Rong J, Chaudhary AF, Li G, Hu J, Davenport AT, Daunais JB, Shao Y, Ran C, Collier TL, Haider A, Schuster DM, Levey AI, Wang L, Corfas G, Liang SH. Acta Pharmaceutica Sinica B, 2025 Oct 1; 15 (10): 5036 - 5049.Journal ArticleImaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with18F-labeled brain penetrant positron emission tomography (PET) ligand
DOI:10.1016/j.apsb.2025.05.020 -
2025 Aug 8;Presentation4th International Symposium on Inner Ear Therapeutics
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Wallace G, Ji L, Cassinotti LR, Kachman M, Lyssiotis CA, Burant CF, Corfas G. 2025 Mar 26;PreprintLipidomics profiling identifies β-oxidation as a key process in noise-induced hearing loss.
DOI:10.1101/2025.03.25.645361 PMID: 40196644 -
Kostrikov S, Hjortkjaer J, Dau T, Corfas G, Liberman LD, Liberman MC. Hearing Research, 2025 Feb 1; 456:Journal ArticleA modiolar-pillar gradient in auditory-nerve dendritic length: A novel post-synaptic contribution to dynamic range?
DOI:10.1016/j.heares.2024.109172 PMID: 39708764
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