Jiandie Lin, PhD
Bradley M Patten Collegiate Professor in the Life Sciences
Research Professor
Life Sciences Institute
Professor of Cell and Developmental Biology
[email protected]

Available to mentor
Jiandie Lin, PhD
Research Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    Metabolic disease, genomics, hormonal signaling, fatty liver disease

    Qualifications
    • Ph.D.
      Northwestern University, United States
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.
    We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.

    Recent Publications See All Publications
    • Presentation
      Interorgan crosstalk and tissue microenvironment in metabolic liver disease
      Lin J. 2024 Sep 9;
    • Presentation
      Interorgan crosstalk and tissue microenvironment in NASH and NASH-related liver cancer
      Lin J. 2024 Jul 16;
    • Presentation
      Interorgan crosstalk and tissue microenvironment in NASH and NASH-related liver cancer
      Lin J. 2024 Jul 15;
    • Journal Article
      Myokines: metabolic regulation in obesity and type 2 diabetes
      Chen ZT, Weng ZX, Lin JD, Meng ZX. Life Metabolism, 2024 Jun 1; 3 (3): DOI:10.1093/lifemeta/loae006
    • Journal Article
      Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
      Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen X-W, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D. Proc Natl Acad Sci U S A, 2024 May 7; 121 (19): e2322164121 DOI:10.1073/pnas.2322164121
      PMID: 38687799
    • Journal Article
      Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866 DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling.
      Meng Z, Zhou L, Hong S, Qiu X, Chen Z, Liu T, Inoki K, Lin JD. Hepatology, 2024 Feb 1; 79 (2): 409 - 424. DOI:10.1097/HEP.0000000000000537
      PMID: 37505219
    • Journal Article
      Bariatric surgery meets TREM2+ macrophages to alleviate MASH independent of weight loss.
      Meng Z, Lin JD. Hepatology, 2024 Oct 17; DOI:10.1097/HEP.0000000000001125
      PMID: 39417882
    Featured News & Stories
    Department News
    New Publication from the Lin Lab
    A new publication from the Lin Lab has been published in Science Translational Medicine.
    Department News
    New Publication from the Lin Lab
    "Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis," has been published in JCI Insight.
    Department News
    New Publication by the Lin Lab
    "Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice," has been published in Hepatology.