Bradley M Patten Collegiate Professor in the Life Sciences
Research Professor
Life Sciences Institute and Professor of Cell and Developmental Biology
[email protected]
Available to mentor
Jiandie Lin, PhD
Research Professor
Metabolic disease, genomics, hormonal signaling, fatty liver disease
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Ph.D.Northwestern University, United States
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
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Center MemberCaswell Diabetes Institute
Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.
We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.
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Chen ZT, Weng ZX, Lin JD, Meng ZX. Life Metabolism, 2024 Jun 1; 3 (3):Journal ArticleMyokines: metabolic regulation in obesity and type 2 diabetes
DOI:10.1093/lifemeta/loae006 -
Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen X-W, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D. Proc Natl Acad Sci U S A, 2024 May 7; 121 (19): e2322164121Journal ArticleFunctional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
DOI:10.1073/pnas.2322164121 PMID: 38687799 -
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866Journal ArticleHepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
DOI:10.1126/scitranslmed.adk1866 PMID: 38478630 -
Meng Z, Zhou L, Hong S, Qiu X, Chen Z, Liu T, Inoki K, Lin JD. Hepatology, 2024 Feb 1; 79 (2): 409 - 424.Journal ArticleMyeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling.
DOI:10.1097/HEP.0000000000000537 PMID: 37505219 -
Chen Z, Zhang P, Liu T, Qiu X, Li S, Lin JD. JCI Insight, 2024 Jan 9; 9 (1):Journal ArticleNeuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.
DOI:10.1172/jci.insight.172957 PMID: 38015639 -
Cheng L, Deepak RNVK, Wang G, Meng Z, Tao L, Xie M, Chi W, Zhang Y, Yang M, Liao Y, Chen R, Liang Y, Zhang J, Huang Y, Wang W, Guo Z, Wang Y, Lin JD, Fan H, Chen L. Hepatology, 2023 Dec 1; 78 (6): 1828 - 1842.Journal ArticleHepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
DOI:10.1097/HEP.0000000000000314 PMID: 36804859 -
Jin L, Han S, Lv X, Li X, Zhang Z, Kuang H, Chen Z, Lv C-A, Peng W, Yang Z, Yang M, Mi L, Liu T, Ma S, Qiu X, Wang Q, Pan X, Shan P, Feng Y, Li J, Wang F, Xie L, Zhao X, Fu J-F, Lin JD, Meng Z-X. Nat Commun, 2023 Jul 19; 14 (1): 4257Journal ArticleThe muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice.
DOI:10.1038/s41467-023-39710-z PMID: 37468484 -
Liu T, Wang Q, Zhou L, Zhang P, Mi L, Qiu X, Chen Z, Kuang H, Li S, Lin JD. Hepatology, 2023 Nov 1; 78 (5): 1478 - 1491.Journal ArticleIntrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice.
DOI:10.1002/hep.32719 PMID: 35950514
Department News
A new publication from the Lin Lab has been published in Science Translational Medicine.
Department News
"Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis," has been published in JCI Insight.
Department News
"Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice," has been published in Hepatology.
