Jiandie Lin, PhD
Bradley M Patten Collegiate Professor in the Life Sciences
Professor of Cell and Developmental Biology
Medical School and Research Professor
Life Sciences Institute
[email protected]

Available to mentor
Jiandie Lin, PhD
Research Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Manage Your Profile
    About

    Metabolic disease, genomics, hormonal signaling, fatty liver disease

    Qualifications
    • Ph.D.
      Northwestern University
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.
    We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.

    Recent Publications See All Publications
    • Journal Article
      Bariatric surgery meets TREM2+ macrophages to alleviate MASH independent of weight loss
      Meng Z, Lin JD. Hepatology, 2025 Jun 1; 81 (6): 1638 - 1640. DOI:10.1097/HEP.0000000000001125
      PMID: 39417882
    • Journal Article
      Famsin and fasting adaptation: A glucagon connection
      Li S, Meng Z, Lin JD. Cell Metabolism, 2025 Mar 4; 37 (3): 561 - 563. DOI:10.1016/j.cmet.2025.01.030
      PMID: 40043687
    • Journal Article
      Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms
      Zhou L, Lu Y, Qiu X, Chen Z, Tang Y, Meng Z, Yan C, Du H, Li S, Lin JD. Cell Reports, 2025 Feb 25; 44 (2): DOI:10.1016/j.celrep.2025.115310
      PMID: 39954254
    • Presentation
      Remodeling of liver microenvironment in metabolic liver disease and cancer
      Lin J. 2025 Feb 27;
    • Presentation
      Interorgan crosstalk and tissue microenvironment in metabolic liver disease
      Lin J. 2024 Dec 10;
    • Presentation
      Interorgan crosstalk and tissue microenvironment in NASH and NASH-related liver cancer
      Lin J. 2024 Dec 11;
    • Presentation
      Interorgan crosstalk and tissue microenvironment in NASH and NASH-related liver cancer
      Lin J. 2024 Dec 11;
    • Journal Article
      Myokines: metabolic regulation in obesity and type 2 diabetes
      Chen ZT, Weng ZX, Lin JD, Meng ZX. Life Metabolism, 2024 Jun 1; 3 (3): DOI:10.1093/lifemeta/loae006
    Featured News & Stories Cell Reports image
    Department News
    New Publication by the Jiandie Lin Lab!
    Cell Reports published "Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms."
    Department News
    New Publication from the Lin Lab
    A new publication from the Lin Lab has been published in Science Translational Medicine.
    Department News
    New Publication from the Lin Lab
    "Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis," has been published in JCI Insight.
    Department News
    New Publication by the Lin Lab
    "Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice," has been published in Hepatology.