Sharan Srinivasan, MD, PhD
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About
Dr. Sharan Srinivasan is an Assistant Professor within the Movement Disorders Division in the Department of Neurology at the University of Michigan. He attended Northwestern University for his bachelor's degree and obtained his combined M.D. Ph.D. at the University of Michigan. He then completed his residency in Neurology at the University of Michigan before pursuing a movement disorders fellowship at Mass General Brigham (Harvard). He returned to the University of Michigan in 2022 to continue his clinical and scientific efforts in caring for and treating cerebellar ataxias.
Links
http://www.srinivasanlab.com/
Qualifications
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FellowshipMass General Brigham, Neurology, Boston, United States
2020 - 2022
Clinical Fellowship
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ResidencyUniversity of Michigan–Ann Arbor, Neurology, Ann Arbor, United States
2017 - 2020
Residency
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InternshipUniversity of Michigan–Ann Arbor, Internal Medicine, Ann Arbor, United States
2016 - 2017
Internship
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MDUniversity of Michigan, Ann Arbor, United States
2009 - 2016
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PhDUniversity of Michigan, Ann Arbor, United States
2011 - 2016
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BANorthwestern University, Evanston, United States
2005 - 2009
Center Memberships
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Center MemberFrankel Institute for Heart and Brain Health
Research Overview
His clinical and research interests involve the pathophysiology of cerebellar ataxias, particularly hereditary polyglutamine disorders. His passion is in developing novel therapeutics via a multidisciplinary approach, combining strategies from organic chemistry, molecular biology, neuro-circuitry, and emerging genetic technologies. His focus has been on targeting impaired neuronal circuitry within these disorders, amelioration of which has been shown to improve motor symptoms and delay degeneration.
Lab website: www.srinivasanlab.com
Recent Publications
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Soto I, Bonomo M, Nelthrope BS, Carr BD, Palmer E, Sierra M, Erturk I, Peppercorn D, Cox E, Vasconcellos TK, Paulson HL, Shorrock HK, Srinivasan SR. Annals of Neurology, 2026 Jan 1;Journal ArticleCardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing
DOI:10.1002/ana.78282 -
He D, Yano S, Li S, Gary A, Mook A, Lu H, Srinivasan S, Todd P, Shakkottai V, Das S. Genetics in Medicine Open, 2026 Mar 7; 4: 104134Journal ArticleP644: Spinocerebellar ataxia type 50: Recurrent p.(Gly389Arg) variant highlights a shared molecular mechanism and expands the clinical spectrum
DOI:10.1016/j.gimo.2026.104134 -
Srinivasan S, Mook A, Rochman M, Yun J, Chen H, Mu W, Wilmot G, Rosenthal L, Uhlmann W. 2025 Aug 28;Journal ArticlePractice Recommendations for Genetic Testing of Ataxias
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Peppel L, Lai R-Y, Rummey C, Opal P, Schmahmann JD, Gomez CM, Paulson H, Zesiewicz TA, Perlman S, Wilmot G, Ying SH, Onyike CU, Bushara KO, Geschwind MD, Figueroa KP, Pulst SM, Subramony SH, Duquette A, Ashizawa T, Hamedani AG, Davis MY, Srinivasan SR, Burns MR, Amokrane N, Moore LR, Shakkottai VG, Rosenthal LS, Kuo S-H, Lin C-YR. J Neuropsychiatry Clin Neurosci, 2025 May 12; appineuropsych20250006Journal ArticleSuicidal Ideation in Spinocerebellar Ataxia.
DOI:10.1176/appi.neuropsych.20250006 PMID: 40350965 -
Soto I, Bonomo M, Nelthrope B, Sierra M, Paulson H, Shorrock H, Srinivasan S. 2025 May 27;Proceeding / Abstract / PosterImproving Neuronal Function as Treatment for Spinocerebellar Ataxias (SCAs)
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Bonomo M, Soto I, Guo A, Paulson H, Srinivasan S. 2024 Nov 27;Proceeding / Abstract / PosterCircuit Modulation as a Pharmacomimetic of Cardiovascular Exercise in Spinocerebellar Ataxia
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Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. Neurology, 2024 Apr 11; 102 (7_supplement_1):Journal ArticleDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic (P7-3.017)
DOI:10.1212/wnl.0000000000205545 -
Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. 2024 Apr 17;Proceeding / Abstract / PosterDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic
DOI:10.1212/WNL.0000000000205545
