Sharan Srinivasan
Assistant Professor of Neurology
[email protected]

Available to mentor

Sharan Srinivasan
Assistant Professor
  • About
  • Research Overview
  • Recent Publications
  • About

    Dr. Sharan Srinivasan is an Assistant Professor within the Movement Disorders Division in the Department of Neurology at the University of Michigan. He attended Northwestern University for his bachelor's degree and obtained his combined M.D. Ph.D. at the University of Michigan. He then completed his residency in Neurology at the University of Michigan before pursuing a movement disorders fellowship at Mass General Brigham (Harvard). He returned to the University of Michigan in 2022 to continue his clinical and scientific efforts in caring for and treating cerebellar ataxias.

    Research Overview

    His clinical and research interests involve the pathophysiology of cerebellar ataxias, particularly hereditary polyglutamine disorders. His passion is in developing novel therapeutics via a multidisciplinary approach, combining strategies from organic chemistry, molecular biology, neuro-circuitry, and emerging genetic technologies. His focus has been on targeting impaired neuronal circuitry within these disorders, amelioration of which has been shown to improve motor symptoms and delay degeneration.

    Lab website: srinivasanlab.com

    Recent Publications See All Publications
    • Journal Article
      Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping.
      Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills A-M, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Cerebellum, 2024 Feb; 23 (1): 52 - 53. DOI:10.1007/s12311-022-01501-5
      PMID: 36456723
    • Journal Article
      T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.
      Matthews LG, Puryear CB, Correia SS, Srinivasan S, Belfort GM, Pan M-K, Kuo S-H. Ann Clin Transl Neurol, 2023 Apr; 10 (4): 462 - 483. DOI:10.1002/acn3.51735
      PMID: 36738196
    • Chapter
      Chapter 18 Repeat expansion disorders ∗
      Srinivasan SR, de Gusmao CM, Korecka JA, Khurana V. 2023 Neurobiology of Brain Disorders, 293 - 312. DOI:10.1016/b978-0-323-85654-6.00048-4
    • Chapter
      Seeking Therapies for Spinocerebellar Ataxia: From Gene Silencing to Systems-Based Approaches
      Powers R, Paulson H, Srinivasan S. 2023 Jan 1; Part F6: Contemporary Clinical Neuroscience, 183 - 207. DOI:10.1007/978-3-031-24345-5_6
    • Journal Article
      Targeting Circuit Abnormalities in Neurodegenerative Disease.
      Srinivasan SR. Mol Pharmacol, 2023 Jan; 103 (1): 38 - 44. DOI:10.1124/molpharm.122.000563
      PMID: 36310030
    • Journal Article
      Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia.
      Srinivasan SR, Huang H, Chang W-C, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. Mol Pharmacol, 2022 Jul; 102 (1): 438 - 449. DOI:10.1124/molpharm.121.000478
      PMID: 35489717
    • Journal Article
      Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.
      Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills A-M, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Cerebellum, 2024 Feb; 23 (1): 31 - 51. DOI:10.1007/s12311-022-01471-8
      PMID: 36190676
    • Proceeding / Abstract / Poster
      Augmenting BK Channel Function as Therapy for Spinocerebellar Ataxia (SCA)
      Srinivasan S, Bushart D, Shakkottai V. NEUROLOGY, 2020 94 (15):