Available to mentor
Dr. Sharan Srinivasan is an Assistant Professor within the Movement Disorders Division in the Department of Neurology at the University of Michigan. He attended Northwestern University for his bachelor's degree and obtained his combined M.D. Ph.D. at the University of Michigan. He then completed his residency in Neurology at the University of Michigan before pursuing a movement disorders fellowship at Mass General Brigham (Harvard). He returned to the University of Michigan in 2022 to continue his clinical and scientific efforts in caring for and treating cerebellar ataxias.
His clinical and research interests involve the pathophysiology of cerebellar ataxias, particularly hereditary polyglutamine disorders. His passion is in developing novel therapeutics via a multidisciplinary approach, combining strategies from organic chemistry, molecular biology, neuro-circuitry, and emerging genetic technologies. His focus has been on targeting impaired neuronal circuitry within these disorders, amelioration of which has been shown to improve motor symptoms and delay degeneration.
Lab website: srinivasanlab.com
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Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills A-M, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Cerebellum, 2024 Feb; 23 (1): 31 - 51.Journal ArticleClinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.
DOI:10.1007/s12311-022-01471-8 PMID: 36190676 -
Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills A-M, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Cerebellum, 2024 Feb; 23 (1): 52 - 53.Journal ArticleCorrection to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping.
DOI:10.1007/s12311-022-01501-5 PMID: 36456723 -
Matthews LG, Puryear CB, Correia SS, Srinivasan S, Belfort GM, Pan M-K, Kuo S-H. Ann Clin Transl Neurol, 2023 Apr; 10 (4): 462 - 483.Journal ArticleT-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.
DOI:10.1002/acn3.51735 PMID: 36738196 -
Srinivasan SR, de Gusmao CM, Korecka JA, Khurana V. 2023 Neurobiology of Brain Disorders, 293 - 312.ChapterChapter 18 Repeat expansion disorders ∗
DOI:10.1016/b978-0-323-85654-6.00048-4 -
Powers R, Paulson H, Srinivasan S. 2023 Jan 1; Part F6: Contemporary Clinical Neuroscience, 183 - 207.ChapterSeeking Therapies for Spinocerebellar Ataxia: From Gene Silencing to Systems-Based Approaches
DOI:10.1007/978-3-031-24345-5_6 -
Srinivasan SR. Mol Pharmacol, 2023 Jan; 103 (1): 38 - 44.Journal ArticleTargeting Circuit Abnormalities in Neurodegenerative Disease.
DOI:10.1124/molpharm.122.000563 PMID: 36310030 -
Srinivasan SR, Huang H, Chang W-C, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. Mol Pharmacol, 2022 Jul; 102 (1): 438 - 449.Journal ArticleDiscovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia.
DOI:10.1124/molpharm.121.000478 PMID: 35489717 -
Srinivasan S, Bushart D, Shakkottai V. NEUROLOGY, 2020 94 (15):Proceeding / Abstract / PosterAugmenting BK Channel Function as Therapy for Spinocerebellar Ataxia (SCA)
