Julie Ziobro, MD PhD
Assistant Professor of Pediatrics
Medical School
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Julie Ziobro, MD PhD
Assistant Professor
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About
Dr. Ziobro received her MD and PhD degrees from Virginia Commonwealth University, with doctoral studies in Neuroscience. She completed pediatric and pediatric neurology residencies at Children's National Hospital in Washington, DC and a pediatric epilepsy fellowship at Children's Hospital Colorado. She joined the faculty at the University of Michigan in 2018. Her clinical interests include genetic epilepsies and clinical trials for epilepsy.
Qualifications
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Pediatric Epilepsy FellowshipChildren's Hospital Colorado, United States
2017 - 2018
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Child Neurology ResidencyChildren's National Hospital, United States
2014 - 2017
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Pediatrics ResidencyChildren's National Hospital, Washington, DC, United States
2012 - 2014
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MD, PhDVirginia Commonwealth University School of Medicine, Richmond, VA, United States
2005 - 2012
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BSMichigan State University, East Lansing, Michigan, United States
2001 - 2004
Research Overview
Dr. Ziobro is a basic science researcher and focuses on models of genetic epilepsies, including SCN1A and PCDH19. Her studies focus on understanding mechanisms of neuronal hyperexcitability and examining potential therapeutic targets. In addition, she is interested in examining gene-targeted therapies in rodent models of epilepsy. Dr. Ziobro is involved in several clinical research studies of epilepsy genetics and sponsored clinical trials for Dravet Syndrome.
Recent Publications
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Hill* SF, Yu* W, Ziobro J, Chalasani S, Reger F, Meisler MH. Annals of Neurology, 2024 Apr 1; 95 (4): 754 - 759.Journal ArticleLong-Term Downregulation of the Sodium Channel Gene Scn8a Is Therapeutic in Mouse Models of SCN8A Epilepsy
DOI:10.1002/ana.26861 PMID: 38113311 -
Kao HY, Yao Y, Yang T, Ziobro J, Zylinski M, Mir MY, Hu S, Cao R, Borna NN, Banerjee R, Parent JM, Wang S, Leventhal DK, Li P, Wang Y. Annals of Neurology, 2023 Nov 1; 94 (5): 812 - 824.Journal ArticleSudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-Related Epilepsy
DOI:10.1002/ana.26773 PMID: 37606181 -
Chen C, Ziobro J, Robinson-Cooper L, Hodges SL, Chen Y, Edokobi N, Lopez-Santiago L, Habig K, Moore C, Minton J, Bramson S, Scheuing C, Daddo N, Štěrbová K, Weckhuysen S, Parent JM, Isom LL. Brain Communications, 2023 Jan 1; 5 (6):Journal ArticleEpilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy
DOI:10.1093/braincomms/fcad283 -
Coombs ID, Ziobro J, Krotov V, Surtees TL, Cull-Candy SG, Farrant M. Epilepsia, 2022 Dec 1; 63 (12): e156 - e163.Journal ArticleA gain-of-function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment
DOI:10.1111/epi.17419 PMID: 36161652 -
McKnight D, Morales A, Hatchell KE, Bristow SL, Bonkowsky JL, Perry MS, Berg AT, Borlot F, Esplin ED, Moretz C, Angione K, Ríos-Pohl L, Nussbaum RL, Aradhya S, ELEVIATE Consortium , Haldeman-Englert CR, Levy RJ, Parachuri VG, Lay-Son G, de Montellano DJD-O, Ramirez-Garcia MA, Benítez Alonso EO, Ziobro J, Chirita-Emandi A, Felix TM, Kulasa-Luke D, Megarbane A, Karkare S, Chagnon SL, Humberson JB, Assaf MJ, Silva S, Zarroli K, Boyarchuk O, Nelson GR, Palmquist R, Hammond KC, Hwang ST, Boutlier SB, Nolan M, Batley KY, Chavda D, Reyes-Silva CA, Miroshnikov O, Zuccarelli B, Amlie-Wolf L, Wheless JW, Seinfeld S, Kanhangad M, Freeman JL, Monroy-Santoyo S, Rodriguez-Vazquez N, Ryan MM, Machie M, Guerra P, Hassan MJ, Candee MS, Bupp CP, Park KL, Muller E, Lupo P, Pedersen RC, Arain AM, Murphy A, Schatz K, Mu W, Kalika PM, Plaza L, Kellogg MA, Lora EG, Carson RP, Svystilnyk V, Venegas V, Luke RR, Jiang H, Stetsenko T, Dueñas-Roque MM, Trasmonte J, Burke RJ, Hurst ACE, Smith DM, Massingham LJ, Pisani L, Costin CE, Ostrander B, Filloux FM, Ananth AL, Mohamed IS, Nechai A, Dao JM, Fahey MC, Aliu E, Falchek S, Press CA, Treat L, Eschbach K, Starks A, Kammeyer R, Bear JJ, Jacobson M, Chernuha V, Meibos B, Wong K, Sweney MT, Espinoza AC, Van Orman CB, Weinstock A, Kumar A, Soler-Alfonso C, Nolan DA, Raza M, Rojas Carrion MD, Chari G, Marsh ED, Shiloh-Malawsky Y, Parikh S, Gonzalez-Giraldo E, Fulton S, Sogawa Y, Burns K, Malets M, Montiel Blanco JD, Habela CW, Wilson CA, Guzmán GG, Pavliuk M. JAMA Neurol, 2022 Dec 1; 79 (12): 1267 - 1276.Journal ArticleGenetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice.
DOI:10.1001/jamaneurol.2022.3651 PMID: PMC9623482 -
Hill SF, Ziobro JM, Jafar-Nejad P, Rigo F, Meisler MH. Epilepsia, 2022 Oct 1; 63 (10): e125 - e131.Journal ArticleGenetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2
DOI:10.1111/epi.17374 PMID: 35892317 -
Ziobro JM, Eschbach K, Shellhaas RA. Neurotherapeutics, 2021 Jul 1; 18 (3): 1564 - 1581.Journal ArticleNovel Therapeutics for Neonatal Seizures
DOI:10.1007/s13311-021-01085-8 PMID: 34386906 -
Lenk GM, Jafar-Nejad P, Hill SF, Huffman LD, Smolen CE, Wagnon JL, Petit H, Yu W, Ziobro J, Bhatia K, Parent J, Giger RJ, Rigo F, Meisler MH. Annals of Neurology, 2020 Mar 1; 87 (3): 339 - 346.Journal ArticleScn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome
DOI:10.1002/ana.25676 PMID: 31943325
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