Jacob L Mueller, PhD

 J_Mueller.jpg
Associate Professor of Human Genetics
Associate Chair, Department of Human Genetics
Program Director, Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
Medical School
Office:
MM Medical School
Human Genetics
1241 Catherine St, 4909 Buhl
Ann Arbor, MI 48109-5618
Email:
[email protected]
Phone:
Available to mentor
Jacob L Mueller, PhD
J_Mueller.jpg
Associate Professor
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    • Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design

    Recent Publications

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    • Journal Article
      Acquisition of ampliconic sequences marks a selfish mouse t-haplotype
      Swanepoel CM, Wang G, Zhang L, Brändl B, Bauer H, Tsaytler P, Müller FJ, Herrmann BG, Mueller JL. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-025-66616-9
      PMID: 41326354
    • Journal Article
      An X-to-autosome-to-Y chromosome amplified retrogene family functions in spermatids
      Mier IF, Arlt MF, Lawson AM, Dulka EA, Wooldridge TB, Hoekstra HE, Mueller JL. Current Biology, 2026 Jun 8; 36 (11): 2930 - 2937.e6. DOI:10.1016/j.cub.2026.04.045
      PMID: 42134326
    • Presentation
      Molecular Arms Races Hidden Within Sex Chromosomes
      Mueller J. 2026 Jun 3;
    • Journal Article
      Heightened interest in the human X and Y chromosomes
      Lawson AM, Mueller JL. Proceedings of the National Academy of Sciences of the United States of America, 2025 Jun 24; 122 (25): DOI:10.1073/pnas.2511505122
      PMID: 40523195
    • Journal Article
      Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins
      Arlt MF, Kruger AN, Swanepoel CM, Mueller JL. Proceedings of the National Academy of Sciences of the United States of America, 2025 Feb 19; 122 (7): DOI:10.1073/pnas.2421446122
      PMID: 39928872
    • Journal Article
      Out with the old, in with the new: Meiotic driving of sex chromosome evolution
      Swanepoel CM, Mueller JL. Seminars in Cell and Developmental Biology, 2024 Nov 1; 163: 14 - 21. DOI:10.1016/j.semcdb.2024.04.004
      PMID: 38664120
    • Journal Article
      Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions
      Alektiar JM, Shan M, Radyk MD, Zhang L, Halbrook CJ, Lin L, Espinoza C, Mier IF, Lavoie BL, Salvatore L, di Magliano MP, Cantley LC, Mueller JL, Lyssiotis CA. Plos One, 2024 Jun 1; 19 (6 June): DOI:10.1371/journal.pone.0303577
      PMID: 38843233
    • Presentation
      The mouse t-haplotype: Masquerading as a Sex Chromosome
      Mueller J. 2026 Jun 3;

    Featured News & Stories
    Department News

    Highlighted Publications: January - May 2026

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
         cells floating one looks like an x one looks like a y fuzzy blue vague blue white grey background
    Health Lab

    The Y chromosome is home to surprising jumping genes

    Researchers at Michigan Medicine are studying deer mice to outline how the Y chromosome defends itself against decay by acquiring gene families while holding its own to maintain fertility.
    Department News

    Highlighted Publications: August - December 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
         sperm moving to cell all blue and cell red
    Health Lab

    Battle of the sex chromosomes

    A study from University of Michigan researchers has uncovered the mechanism behind the arms race for mouse X and Y bearing sperm to fertilize an egg.
    Department News

    Highlighted Publications - February 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    PNAS Comments on Dr. Martin Arlt's Study

    PNAS comments on Dr. Martin Arlt's study "Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins" on March 3, 2025.