Jacob L Mueller, PhD
Associate Professor of Human Genetics
Associate Chair, Department of Human Genetics
Program Director, Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
Medical School
[email protected]
Available to mentor
Jacob L Mueller, PhD
Associate Professor
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Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
Recent Publications
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Swanepoel CM, Wang G, Zhang L, Brändl B, Bauer H, Tsaytler P, Müller FJ, Herrmann BG, Mueller JL. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleAcquisition of ampliconic sequences marks a selfish mouse t-haplotype
DOI:10.1038/s41467-025-66616-9 PMID: 41326354 -
Mier IF, Arlt MF, Lawson AM, Dulka EA, Wooldridge TB, Hoekstra HE, Mueller JL. Curr Biol, 2026 May 13;Journal ArticleAn X-to-autosome-to-Y chromosome amplified retrogene family functions in spermatids.
DOI:10.1016/j.cub.2026.04.045 PMID: 42134326 -
Mueller J. 2026 Jun 3;PresentationTBD
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Lawson AM, Mueller JL. Proceedings of the National Academy of Sciences of the United States of America, 2025 Jun 24; 122 (25):Journal ArticleHeightened interest in the human X and Y chromosomes
DOI:10.1073/pnas.2511505122 PMID: 40523195 -
Arlt MF, Kruger AN, Swanepoel CM, Mueller JL. Proceedings of the National Academy of Sciences of the United States of America, 2025 Feb 19; 122 (7):Journal ArticleReenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins
DOI:10.1073/pnas.2421446122 PMID: 39928872 -
Swanepoel CM, Wang G, Zhang L, Brändl B, Bauer H, Tsaytler P, Müller F-J, Herrmann BG, Mueller JL. 2025 Jan 29;PreprintAcquisition of ampliconic sequences marks a selfish mouse t-haplotype.
DOI:10.1101/2025.01.28.635315 PMID: 39975218 -
Swanepoel CM, Mueller JL. Seminars in Cell and Developmental Biology, 2024 Nov 1; 163: 14 - 21.Journal ArticleOut with the old, in with the new: Meiotic driving of sex chromosome evolution
DOI:10.1016/j.semcdb.2024.04.004 PMID: 38664120 -
Arlt MF, Kruger AN, Swanepoel CM, Mueller JL. bioRxiv, 2024 Oct 22;Journal ArticleReenacting a mouse genetic evolutionary arms race in yeast reveals SLXL1/SLX compete with SLY1/2 for binding to Spindlins.
DOI:10.1101/2024.10.18.619120 PMID: PMC11526915
Featured News & Stories
Health Lab
The Y chromosome is home to surprising jumping genes
Researchers at Michigan Medicine are studying deer mice to outline how the Y chromosome defends itself against decay by acquiring gene families while holding its own to maintain fertility.
Health Lab
Battle of the sex chromosomes
A study from University of Michigan researchers has uncovered the mechanism behind the arms race for mouse X and Y bearing sperm to fertilize an egg.
Department News
Highlighted Publications - February 2025
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
PNAS Comments on Dr. Martin Arlt's Study
PNAS comments on Dr. Martin Arlt's study "Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins" on March 3, 2025.
Department News
Highlighted Publications - April 2024
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Next Generation GENE-iuses
This summer, a group of local 4th and 5th grade students made a visit to the Department of Human Genetics to meet scientists and get hands-on experience with genetics. Their visit was coordinated by Dr. Diane Robins and Dr. Cristen Willer.
