Lars Fritsche, PhD
Research Associate Professor, Anesthesiology, Medical School
Research Associate Professor, Biostatistics, School of Public Health
[email protected]
Available to mentor
Lars Fritsche, PhD
Research Associate Professor
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About
Statistical geneticist and biostatistician leading scalable precision-medicine methods for EHR-linked biobanks and clinical cohorts. Research integrates GWAS, phenotyping, polygenic risk scoring, pharmacogenetics, and multimodal prediction to support precision mental health and pain-focused translational studies. Building on platform methods and shared resources, including Cancer PRSweb and ExPRSweb, current work deploys these frameworks in ongoing mental health and pain-focused NIH-funded programs. Current program combines genetics, EHRs, and mobile data as MPI on NIH-NIMH U01 MH136025 (COMPASS).
Links
PRSweb Portals Google Scholar
Qualifications
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Postdoctoral Research FellowUniversity of Michigan, Department of Biostatistics, Ann Arbor, United States
2012 - 2014
Postdoctoral Fellowship
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Postdoctoral Research FellowUniversity of Regensburg, Institute of Human Genetics, Regensburg, Germany
2009 - 2012
Postdoctoral Fellowship
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PhD, Human GeneticsUniversity of Regensburg, Regensburg, Germany
2005 - 2009
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Diploma in Biology, GeneticsUniversity of Regensburg, Regensburg, Germany
1999 - 2004
Center Memberships
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Center MemberAI and Digital Health Innovation
Research Overview
- Scalable PRS methods, evaluation, and resource sharing
- Precision mental health and treatment response
- EHR-based pain phenotyping and risk stratification
- Multimodal precision medicine in health-system-linked cohorts
Recent Publications
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Fritsche LG, Higgins LM, Schipper M, Strohbehn G, McMahon BH, Crivelli S, Dai X, Yoo S, Vanderwerff B, Bertucci-Richter E, Elliott D, Green MD, Bryant AK. Clin Cancer Res, 2026 Jun 3;Journal ArticlePolygenic risk scores for prediction of immune checkpoint inhibitor thyroid toxicity in diverse populations.
DOI:10.1158/1078-0432.CCR-26-0620 PMID: 42240401 -
Fritsche L. 2026 Jun 5;Additional ScholarshipNIH Common Forms (SciENcv) Playbook. Independent PI and administrator guide for preparing NIH Common Forms in SciENcv, including role-based quickstarts, templates, troubleshooting, XML upload support, and curated NIH/NCBI references.
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Riedl S, Mai J, Enzendorfer ML, Nugawela MD, Fritsche L, Prevost T, Rueckert D, Menten M, Scholl H, Sivaprasad S, Lotery A, Bogunovic H, Sacu S, Schmidt-Erfurth U. Br J Ophthalmol, 2026 May 8;Journal ArticleOCT-based AI-assisted phenotyping of intermediate AMD in the prospective PINNACLE trial: PINNACLE Study Report 9.
DOI:10.1136/bjo-2025-327938 PMID: 42103449 -
Fritsche L. 2026 Jun 2;PresentationScalable Data Curation: LLM-Driven Harmonization of EHR Medication Labels
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Moolhuijsen LME, Zhu J, Mullin BH, Pujol-Gualdo N, Actkins KV, Mack JA, Rao H, Trivedi B, Kentistou KA, Zhao Y, Westergaard D, Tyrmi JS, Thorleifsson G, Zhang Y, Wittemans L, DeVries A, Brewer K, Sisk R, Danning R, Preuss MH, Jones MR, Ruth KS, Andersen M, Azziz R, Banasik K, Boehnke M, Broer L, Brunak S, Chan Y-M, Chasman DI, Daly M, Ehrmann DA, Fauser BC, Fritsche LG, Hayes MG, He C, Huang H, Kowalska I, Kraft P, Legro RS, Lin N, Loos RJ, Louwers YV, Magi R, McCarthy MI, Morin-Papunen L, Morrison JV, Morton C, Nadkarni GN, Neale BM, Nielsen HS, Nyegaard M, Ostrowski SR, Pedersen OBV, Sørensen E, Mikkelsen C, Erikstrup C, Kaspersen KA, Bruun MT, Aagaard B, Ullum H, Obermayer-Pietsch B, Palotie A, Reeve MP, Salumets A, Saxena R, Spector TD, Stuckey BGA, Thorsteinsdottir U, Uitterlinden AG, Urbanek M, Zöllner S, Genes and Health Research Team , DBDS Genomic Consortium , 23andMe Research Team , van Heel DA, Hirschhorn JN, Stefansson K, Perry JRB, Styrkarsdottir U, Wilson SG, Piltonen T, Laisk T, Jarvelin M-R, Burns K, Justice AE, Laivuori H, Ong KK, Goodarzi MO, Davis LK, Dunaif A, Lindgren CM, Laven JSE, Franks S, Visser JA, Welt CK, Karaderi T, Day FR. Nat Genet, 2026 Apr 23;Journal ArticleGenomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.
DOI:10.1038/s41588-026-02543-9 PMID: 42026183 -
Thakur R, Jayasinghe GJMSR, Xu M, Bui-Raborn L, Shi J, Dutta D, Hoang PH, Seviiri M, Amos CI, Bakshi A, Cust AE, Demenais F, Duffy DL, Fritsche LG, Han J, Hayward NK, Khosrotehrani K, Kumar R, Thompson JF, MacGregor S, Renteria M, Smelser DT, Ward SV, Fargnoli MC, Ghiorzo P, Goldstein AM, Menin C, Millan-Esteban D, Nagore E, Pellegrini C, Puig S, Stratigos A, Whiteman DC, Meta-Analysis Consortium M, Iles MM, Whelees LE, Hartman RI, Landi MT, Law MH, Brown KM. Cancer Research, 2026 Apr 19; 86 (8_Supplement): lb384 - lb384.Journal ArticleAbstract LB384: H3K27ac-HiChIP variant-to-gene mapping confirms the importance of cancer drivers and oncogenic signaling pathways in melanoma risk
DOI:10.1158/1538-7445.am2026-lb384 -
Wang D, Ye W, Zhu J, Xu G, Tang W, Zawistowski M, Fritsche LG, He K. Journal of the Royal Statistical Society Series A (Statistics in Society), 2026 Apr 3; qnag042Journal ArticleIncorporating external risk information with the Cox model under population heterogeneity: applications to trans-ancestry polygenic hazard scores
DOI:10.1093/jrsssa/qnag042 -
Bohnert ASB, Fritsche L, Sen S. Biol Psychiatry Cogn Neurosci Neuroimaging, 2026 Jan 19;Journal ArticlePrecision approaches for scalable digital and clinic-based interventions in mental health.
DOI:10.1016/j.bpsc.2026.01.004 PMID: 41565105
