Gary D Luker, MD

 Gary D. Luker
Reed Dunnick Research Professor of Radiology
Associate Chair, Radiology Clinical Research
Professor of Biomedical Engineering
Medical School
Office:
University of Michigan
Radiology
109 Zina Pitcher Place, BSRB A710
Ann Arbor, MI 48109-2200
Email:
[email protected]
Available to mentor
Gary D Luker, MD
Gary D. Luker
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    I am a physician-scientist whose research centers at the interface of cancer biology and molecular imaging. I serve as the Editor of the RSNA journal, Radiology: Imaging Cancer.

    Links
    • Lab website

    Qualifications
    • Research Fellowship
      Washington University in St. Louis School of Medicine, Laboratory of Molecular Radiopharmacology, St Louis, United States
      1996 - 2002
      Postdoctoral Fellowship
    • Fellowship
      Mallinckrodt Institute of Radiology, Pediatric Radiology, St. Louis, United States
      1995 - 1996
      Postdoctoral Fellowship
    • Residency
      Washington University in St. Louis School of Medicine, Diagnostic Radiology, St Louis, United States
      1991 - 1995
      Residency
    • MD
      Washington University School of Medicine, St Louis, MO, United States
      1987 - 1991

    Center Memberships
    • Center Member
      Rogel Cancer Center

    Research Overview

    The Luker Lab investigates tumor-stromal interactions in cancer that drive tumor growth, metastasis, and drug resistance. The lab applies multi-scale imaging methods to understand tumor heterogeneity and predict early responses to therapy in models ranging from single cells to clinical studies.

    Recent Publications

     See All Publications
    • Journal Article
      Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis
      Viola H, Carter H, Griffin K, Costa RM, McDonald R, Callow B, Gonzalez de Los Santos F, Panovich P, Carey S, Martinez M, Chen R, Hunter Z, Piotrowski-Daspit A, Luker G, Moore BB, Shea L. Biomaterials, 2026 Dec 1; 335: DOI:10.1016/j.biomaterials.2026.124388
    • Journal Article
      FP-IRL: Fokker–Planck inverse reinforcement learning — A physics-constrained approach to Markov decision processes
      Huang C, Srivastava S, Ho KKY, Luker KE, Luker GD, Huan X, Garikipati K. Computer Methods in Applied Mechanics and Engineering, 2026 Aug 15; 458: DOI:10.1016/j.cma.2026.119010
    • Journal Article
      Quantitative Spatiotemporal Analysis of Intracellular Kinase Activity in Metastatic Breast Cancer Cells Using a Microfluidic-Based Lateral Diffusion Assay
      Fuller BT, Jones TH, Chan ET, D’Souza MW, Luker KE, Luker GD, Song JW. Analytical Chemistry, 2026 Jun 30; 98 (25): 18607 - 18622. DOI:10.1021/acs.analchem.6c01060
    • Journal Article
      On-Scanner Correction of Gradient Nonlinearity Bias for Accurate Assessment of Diffusion Heterogeneity Across Bone Sites in Myelofibrosis Patients
      Malyarenko D, Ross BD, Peeters JM, Devaraj A, Jafari R, Tariq H, Pettit KM, Talpaz M, Luker GD, Chenevert TL. Magnetic Resonance in Medicine, 2026 Jun 1; 95 (6): 3386 - 3395. DOI:10.1002/mrm.70273
      PMID: 41612146
    • Preprint
      FP-IRL: Fokker--Planck Inverse Reinforcement Learning -- A Physics-Constrained Approach to Markov Decision Processes
      Huang C, Srivastava S, Ho KKY, Luker KE, Luker GD, Huan X, Garikipati K. 2023 Jun 22; arXiv, DOI:10.48550/arxiv.2306.10407
    • Journal Article
      2025 Manuscript Reviewers: A Note of Thanks
      Radiology Imaging Cancer, 2026 Mar 1; 8 (2): e260186 DOI:10.1148/rycan.260186
      PMID: 41891823
    • Journal Article
      Editor's Recognition Awards
      Radiology Imaging Cancer, 2026 Mar 1; 8 (2): e260187 DOI:10.1148/rycan.260187
      PMID: 41891824
    • Journal Article
      Abstract PS2-07-22: Serial, multi-omic, multi-analyte, liquid biopsy monitoring of metastatic lobular breast cancer to detect clinically-relevant heterogeneity and evolution
      Cani AK, Dolce EM, Darga EP, Hu K, Liu C, Robinson D, Wu Y, Paoletti C, Luker GD, Tomlins SA, Udager AM, Henderson NC, Thomas DG, Rae JM, Arul CM, Cobain EF, Hayes DF. Clinical Cancer Research, 2026 Feb 23; 32 (4_Supplement): ps2-07-22-ps2-07-22 DOI:10.1158/1557-3265.sabcs25-ps2-07-22

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    Health Lab

    How breast cancer cells survive in bone marrow after remission

    A new study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.