Professor of Radiology
Associate Chair, Department of Radiology
Professor of Biomedical Engineering
Radiology
109 Zina Pitcher Place, BSRB A710
Ann Arbor, MI 48109-2200
[email protected]
109 Zina Pitcher Place, BSRB A710
Ann Arbor, MI 48109-2200
Available to mentor
Gary D Luker, MD
Professor
I am a physician-scientist whose research centers at the interface of cancer biology and molecular imaging. I serve as the Editor of the RSNA journal, Radiology: Imaging Cancer.
Lab website
-
Research FellowshipWashington University in St. Louis School of Medicine, Laboratory of Molecular Radiopharmacology, 2002
-
FellowshipMallinckrodt Institute of Radiology, Pediatric Radiology, 1996
-
ResidencyWashington University in St. Louis School of Medicine, Diagnostic Radiology, 1995
-
Center MemberRogel Cancer Center
The Luker Lab investigates tumor-stromal interactions in cancer that drive tumor growth, metastasis, and drug resistance. The lab applies multi-scale imaging methods to understand tumor heterogeneity and predict early responses to therapy in models ranging from single cells to clinical studies.
-
Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ. NPJ Syst Biol Appl, 2024 Apr 18; 10 (1): 42Journal ArticleCharacterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays.
DOI:10.1038/s41540-024-00369-x PMID: 38637530 -
Liu Y, Yao C-Y, Rambo TM, Li B, Juhong A, Doredla JS, Luker GD, Han M, Miller AJ, Qiu Z. Optics Letters, 2024 Nov 15; 49 (22): 6349Journal ArticleSuperconducting nanowire single-photon detector enhanced near-infrared II portable confocal microscopy for tissue imaging with indocyanine green
DOI:10.1364/ol.537612 -
Rafsanjani Nejad P, Lamichhane A, Guragain P, Luker G, Tavana H. Lab Chip, 2024 Nov 1;Journal ArticleA gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics.
DOI:10.1039/d4lc00404c PMID: 39485368 -
Sinha S, Callow BW, Farfel AP, Roy S, Chen S, Masotti M, Rajendran S, Buschhaus JM, Espinoza CR, Luker KE, Ghosh P, Luker GD. J Clin Invest, 2024 Oct 31;Journal ArticleBreast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels.
DOI:10.1172/JCI170953 PMID: 39480488 -
Kinnunen PC, Srivastava S, Wang Z, Ho KKY, Humphries BA, Chen S, Linderman JJ, Luker GD, Luker KE, Garikipati K. 2024 Oct 24;PreprintInference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells.
PMID: 39502887 -
Juhong A, Li B, Liu Y, Yang CW, Yao CY, Agnew DW, Lei YL, Luker GD, Bumpers H, Huang X, Piyawattanametha W, Qiu Z. Advanced Intelligent Systems, 2024 Oct 1; 6 (10):Journal ArticleMultihead Attention U-Net for Magnetic Particle Imaging–Computed Tomography Image Segmentation
DOI:10.1002/aisy.202400007 -
Akter M, Moghimianavval H, Luker GD, Liu AP. 2024 Sep 15;PreprintLight-triggered protease-mediated release of actin-bound cargo from synthetic cells.
DOI:10.1101/2024.09.15.613133 PMID: 39314483 -
Sinha S, Callow BW, Farfel AP, Roy S, Chen S, Rajendran S, Buschhaus JM, Espinoza CR, Luker KE, Ghosh P, Luker GD. 2024 Aug 10;PreprintBreast Cancers That Disseminate to Bone Marrow Acquire Aggressive Phenotypes through CX43-related Tumor-Stroma Tunnels.
DOI:10.1101/2023.03.18.533175 PMID: 36993616
Health Lab
A new study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.
