S P Hicks Endowed Professor of Pathology
Section Head, Michigan Center for Translational Pathology
Professor of Pathology and Professor of Urology
Medical School
[email protected]
Available to mentor
Arul M Chinnaiyan
Professor
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Center MemberMM-PKUHSC Joint Institute
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Center MemberPrecision Health Initiative
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Center MemberTaubman Institute
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Center MemberGlobal REACH
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
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Gondal MN, Cieslik M, Chinnaiyan AM. Scientific Data, 2025 Dec 1; 12 (1):Journal ArticleIntegrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients
DOI:10.1038/s41597-025-04381-6 PMID: 39843468 -
Eyunni S, Mannan R, Zhang Y, Young E, Zhang Q, Luo J, Pang M, Mahapatra S, Tien JC-Y, George JM, Jaber M, Hakkani H, Carson SE, Todd AJ, Hosseini N, Gondal M, Rebernick RJ, Cao X, Su F, Wang R, Mehra R, Li J, Cieslik M, Chinnaiyan AM, Parolia A. Science, 2025 Jun 26; eadv2367Journal ArticleDivergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.
DOI:10.1126/science.adv2367 PMID: 40570057 -
Iczkowski KA, De Marzo AM, Agarwal N, Berman DM, Cimadamore A, Fine SW, Greenland N, Khani F, Loda M, Lotan TL, Varma M, Chinnaiyan A, Giannarini G, Huang J, Montironi R, Netto GJ, Osunkoya AO, Ratliff T, Kristiansen G, Cheng L, van Leenders GJLH, Members of the ISUP GU Cancer Precursor Consensus Panel . Am J Surg Pathol, 2025 Jun 23;Journal ArticleInternational Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate.
DOI:10.1097/PAS.0000000000002430 PMID: 40545966 -
Mayr L, Neyazi S, Schwark K, Trissal M, Beck A, Labelle J, Eder SK, Weiler-Wichtl L, Marques JG, de Biagi-Junior CAO, Lo Cascio C, Chapman O, Sridhar S, Kenkre R, Dutta A, Wang S, Wang J, Hack O, Nascimento A, Nguyen CM, Castellani S, Rozowsky JS, Groves A, Panditharatna E, Cruzeiro GAV, Haase RD, Tabatabai K, Madlener S, Wadden J, Adam T, Kong S, Miclea M, Patel T, Bruckner K, Senfter D, Lämmerer A, Supko J, Guntner AS, Palova H, Neradil J, Stepien N, Lötsch-Gojo D, Berger W, Leiss U, Rosenmayr V, Dorfer C, Dieckmann K, Peyrl A, Azizi AA, Baumgartner A, Slaby O, Pokorna P, Clark LM, Cameron A, Nguyen QD, Wakimoto H, Dubois F, Greenwald NF, Bandopadhayay P, Beroukhim R, Ligon K, Kramm C, Bronsema A, Bailey S, Stucklin AG, Mueller S, Skrypek M, Martinez N, Bowers DC, Jones DTW, Jones C, Jäger N, Sterba J, Müllauer L, Haberler C, Kumar-Sinha C, Chinnaiyan A, Mody R, Chavez L, Furtner J, Koschmann C, Gojo J, Filbin MG. Cancer Cell, 2025 Apr 14; 43 (4): 740 - 756.e8.Journal ArticleEffective targeting of PDGFRA-altered high-grade glioma with avapritinib
DOI:10.1016/j.ccell.2025.02.018 PMID: 40086436 -
Yang J, Chang Y, Zhou K, Huang W, Tien JCY, Zhang P, Liu W, Zhou L, Zhou Y, Ren X, Mannan R, Mahapatra S, Zhang Y, Hamadeh R, Ervine G, Wang Z, Wang GX, Chinnaiyan AM, Ding K. Journal of Medicinal Chemistry, 2025 Mar 27; 68 (6): 6718 - 6734.Journal ArticleDiscovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition
DOI:10.1021/acs.jmedchem.5c00127 PMID: 40080446 -
Humble R, Paturu R, Xiao H, Yang C, Otsubo A, Brown N, Betz B, Kim A, Chinnaiyan A, Shao L, Mehra R. Laboratory Investigation, 2025 Mar 25; 105 (3): 103050Journal Article817 Clinical Utility of an ERG Fluorescent in situ Hybridization (FISH) Assay: Practical Use and Lessons from an 8-Year Tertiary Institution Experience
DOI:10.1016/j.labinv.2024.103050 -
Mannan R, Zhang Y, Paturu R, Hu J, Mahapatra S, Chinnaiyan A, Wang X, Cao X, Su F, Wang R, Picken M, Palapattu G, Hafez K, Vaishampayan U, Gupta S, Sangoi A, Argani P, Chinnaiyan A, Dhanasekaran S, Mehra R. Laboratory Investigation, 2025 Mar 25; 105 (3): 103086Journal Article853 Genomic Insights and Cell of Origin Concepts Reveal Distal Nephron Origin for SDH-B Deficient Renal Cell Carcinoma
DOI:10.1016/j.labinv.2024.103086 -
Harms PW, Verhaegen ME, Vo JN, Tien JC, Pratt D, Su F, Dhanasekaran SM, Cao X, Mangelberger D, VanGoor J, Choi JE, Ma VT, Dlugosz AA, Chinnaiyan AM. Journal of Investigative Dermatology, 2022 Mar 1; 142 (3): 641 - 652.Journal ArticleViral Status Predicts the Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma
DOI:10.1016/j.jid.2021.07.173 PMID: 34474081
Health Lab
A study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer—drive tumor initiation formation and therapeutic resistance.
Health Lab
A study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer – and offers a potential pathway for new treatments.
Points of Blue
Mahnoor Gondal is a PhD Candidate in Bioinformatics.
Health Lab
A study identifies an enzyme as a new therapeutic target for “cold” tumors.
Health Lab
In two separate papers, U-M researchers describe how a gene alteration drives prostate cancer and a potential degrader that stops it
Health Lab
Researchers have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development.
