Ormond A MacDougald
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About
After his postdoctoral fellowship in Dan Lane's lab at Johns Hopkins, Ormond MacDougald joined the U-M faculty as an Assistant Professor of Physiology. He currently is the John A Faulkner Collegiate Chair of Physiology and Professor of Molecular & Integrative Physiology, and Internal Medicine. Dr MacDougald’s professional interests include all aspects of adipose tissue biology. He is also dedicated to training the next generation of scientists.
Dr. MacDougald has been recognized with numerous awards and accolades, including a Fulbright Scholar's Award. From U-M he is the recipient of the Rackham Distinguished Graduate Mentoring Award and the Basic Science Achievement Award. He also received the Henry Pickering Bowditch Award and the Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist Award from the APS, and is a Fellow of the American Association for the Advancement of Science.
Outside work he mainly spends time with his wife and four children but he also likes to woodwork, garden, and make music.
Links
MacDougald Lab Website
Qualifications
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Postdoctoral FellowJohns Hopkins University School of Medicine, Biological Chemistry, Baltimore, United States
1992 - 1996
Postdoctoral Fellowship
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Ph.D., AgricultureMichigan State University, East Lansing, United States
1988 - 1992
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M.S., AgricultureMichigan State University, East Lansing, United States
1986 - 1988
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B.Sc., AgricultureUniversity of Guelph, Guelph, Canada
1982 - 1986
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
Research Overview
The MacDougald lab has broad interests in how adipocytes throughout the body develop, function, and interact with other cell types near and afar.
Recent Publications
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Mori H, Hariri H, Moe W, Durham S, Guzman Y, Paulsson E, Simmermon RC, Bhanderi PB, Peterson SK, Dickson MJ, Evans CR, MacDougald OA. 2026 Apr 19; bioRxiv,PreprintAdaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation
DOI:10.64898/2026.04.14.718465 -
Bozadjieva-Kramer N, McMahon G, Li Z, Wean J, Shin JH, Myronovych A, O'Rourke RW, MacDougald OA, Seeley RJ. Diabetes, 2026 Apr 1;Journal ArticleGut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss.
DOI:10.2337/db25-0466 PMID: 41920187 -
Maung JN, Oral EA, MacDougald OA. Trends Endocrinol Metab, 2026 Mar 17;Journal ArticleLamin A/C in health, laminopathies, and familial partial lipodystrophy 2.
DOI:10.1016/j.tem.2026.01.010 PMID: PMC13004169 -
Maung JN, Schill RL, Nishii A, Foss de Freitas M, Obua BN, Nygård M, Mendez-Casillas MD, Hermsmeyer ID, Gilio D, Besci O, Chen Y, Desrosiers B, Adler RE, Gomes AD, Celik Guler M, Mori H, Uranga RM, Li Z, Hariri H, Zhang L, de Paula Souza A, Hoose KS, Lewis KT, Hetrick TA, Cederna P, Lumeng CN, Mandrup S, Oral EA, MacDougald OA. Journal of Clinical Investigation, 2026 Jan 2; 136 (1):Journal ArticleAltered lipid metabolism and inflammatory programs associate with adipocyte loss in familial partial lipodystrophy 2
DOI:10.1172/JCI198387 PMID: 41217838 -
Zhang X, Panicker SS, Bollinger JM, Majumdar A, Kheireddine R, Dabill LF, Kim C, Kleiboeker B, Zhang F, Chen Y, Magee KL, Learman BS, Kepecs A, Meyer GA, Liu J, Thomas SA, Lodhi IJ, MacDougald OA, Scheller EL. Nature Metabolism, 2026 Jan 1;Journal ArticleA catecholamine-independent pathway controlling adaptive adipocyte lipolysis
DOI:10.1038/s42255-025-01424-5 PMID: 41507664 -
Riley N, Kasza I, Hermsmeyer IDK, Trautman ME, Barrett-Wilt G, Jain R, Simcox JA, Yen CLE, MacDougald OA, Lamming DW, Alexander CM. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleDietary lipids are largely deposited in skin and rapidly affect insulating properties
DOI:10.1038/s41467-025-59869-x PMID: 40379673 -
Uranga RM, Nishii A, Maung JN, Mori H, Desrosiers B, Jacobs J, Hoose KS, Schill RL, Bagchi DP, Guak H, Crewe C, Dinov ID, Giles ED, Lumeng CN, MacDougald OA. Molecular Metabolism, 2025 Oct 1; 100:Journal ArticleEffects of β-catenin deficiency on adipose tissue physiology
DOI:10.1016/j.molmet.2025.102226 PMID: 40759324 -
Su J, Hashsham A, Kodur N, Burton C, Mancuso A, Singer A, Wloszek J, Tomlinson AJ, Yacawych WT, Flak JN, Lewis KT, Oles LR, Mori H, Bozadjieva-Kramer N, Turcu AF, MacDougald OA, Myers MG, Affinati AH. Molecular Metabolism, 2025 Sep 1; 99:Journal ArticleControl of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability
DOI:10.1016/j.molmet.2025.102216 PMID: 40684983
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