Robert A Koeppe, PhD
Department of Radiology
2276 Medical Science Building ,1301 Catherine St
Ann Arbor, MI 48109
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Qualifications
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PhDUniversity of Wisconsin, Madison, WI, United States
1982 - 1984
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MSUniversity of Wisconsin, Madison, WI, United States
1980 - 1982
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MSUniversity of Missouri, Columbia, MO, United States
1978 - 1980
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BSUniversity of Missouri, Columbia, MO, United States
1973 - 1977
Research Overview
Robert Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.
Recent Publications
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Li X, Rockall AG, Edison P, Mintzer J, Hu W, Seshadri S, Lowe V, Graff-Radford J, Botha H, Knopman D, Jones D, Boeve B, Petersen R, Heidebrink J, Frascino J, Gama A, Brewer J, Boudreau J, Becerra M, Dagerman K, Trejo E, Pawluczyk S, O’Leary K, Martin K, Conant C, Munoz C, Schneider LS, Shang Y, Nguyen M, Ryan J, Taylor J, Devereux G, Schwartz D, Clay T, Thomas A, Pierce A, White S, Kaye J, Silbert L, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Khachaturian Z, Thal L, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Lagarde J, Windon C, Chiotis K, La Joie R, Soleimani-Meigooni D, Shen L, Kaddurah-Daouk R, Lacy K, Apostolova LG, Craft H, Risacher SL, Foroud TM, Trojanowski JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Taylor-Reinwald L, Cairns NJ, Bernhardt H, Franklin E, Morris JC, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Ward C, Reyes C, Borowski B, Forghanian-Arani A, DeCarli C, Thompson P, Fox NC, Felmlee J, Strong J, Germano KK, Hoang I, Glittenberg M. Scientific Reports, 2026 Dec 1; 16 (1):Journal ArticleA computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer’s disease
DOI:10.1038/s41598-026-54109-8 PMID: 42289440 -
Zhang W, Raghavan S, Tian J, Przybelski SA, Wiste HJ, Fought AJ, Senjem ML, Schwarz CG, Reid RI, Machulda MM, Petersen RC, Graff-Radford J, Jack CR, Lowe VJ, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Kachaturian Z, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Shen L, Kaddurah-Daouk R, Lacy K, Potter Z, Faber K, Nudelman K, Apostolova LG, Craft H, Risacher SL, Jo T, Foroud TM, Neu S, Crawford K, Trojanowki JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Franklin E, Morris J, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Talavera S, Di Benedetto J, Ajayi A, Guzman V, Thomas L, Magana F, Weisensel T, Strong J, Germano KK, Hoang I, Glittenberg M, Ayo O, Parkins S, Thao MS, Amaza H, Hussen KA, Saito N, Jenkins C, Pizzola J, Mahboubi P, Adegoke O, Ogwang S, Smith S, Hergesheimer L, Webb C, Shaffer E, Clanton T, Walter S, Cabrera Y, Zimmerman C, Robison J, Boatwright V, Fidell A, Salazar J, Donohue M, Jimenez G, Raman R, Rafii M, Kormos A, Flenniken D. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleDivergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
DOI:10.1038/s41467-026-70707-6 PMID: 41851083 -
Paranhos T, Katsumi Y, Brickhouse MJ, Eloyan A, Eckbo R, Zaitsev A, Du A, La Joie R, Thangarajah M, Taurone A, Vemuri P, Jack CR, Hammers DB, Aisen PS, Beckett LA, Koeppe R, Kukull WA, Toga AW, Atri A, Clark DG, Day GS, Duara R, Graff-Radford NR, Grant IM, Honig LS, Johnson E, Jones DT, Masdeu JC, Mendez MF, Musiek ES, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo T, Wolk DA, Womack KB, Carrillo MC, Rabinovici GD, Apostolova LG, Dickerson BC, Eldaief MC, Touroutoglou A. Neurology, 2026 Oct 13; 107 (7): 1 - 11.Journal ArticleEOAD-Signature Atrophy Predicts Dementia in Early-Onset MCI due to Alzheimer Disease: An MRI-Based Prognostic Biomarker
DOI:10.1212/WNL.0000000000218519 PMID: 42647766 -
Blazhenets G, Soleimani-Meigooni DN, Chiotis K, Allen IE, Rabinovici GD, La Joie R, Apostolova LG, Asken BM, Bejanin A, Benzinger TLS, Betthauser TJ, Bluma M, Bombois S, Bourgeat P, Bouteloup V, Braskie MN, Brendel M, Brickman AM, Bryant N, Bullich S, Carrillo MC, Casaletto K, Cash DM, Chang CC, Chang HI, Chao Y, Chêne G, Chételat G, Coath W, Collij LE, Colmant L, Corrada MM, Craft S, Dickerson BC, Dubois B, Dufouil C, Fajardo A, Farrar G, Fortea J, Frings L, Frisoni GB, Gardner RC, Garibotto V, Gnörich JS, Gordon BA, Gu Y, Guan Y, Guo T, Hanseeuw BJ, Hansson O, Harrison TM, Huang Q, Huang SH, Iaccarino L, Ishii K, Ishi K, Jagust WJ, Johnson SC, Kato T, Katsumi Y, Kaye J, Koeppe RA, Kolinger GD, Kramer JH, Landau SM, Landeau B, Lao PJ, Lee S, Lleó A, Lopresti BJ, Lowe VJ, Luchsinger JA, Malpetti M, Mao X, March A, Masters CL, Meyer PT, Mezenge F, Mormino EC, Franquesa-Mullerat M, Nakamura A, Nordberg A, O'brien JT, O'bryant SE, Pappas I, Peretti DE, Quenon L, Rowe CC, Rowe JB, Rudolph MD, Salvadó G, Schott JM, Schwartz DL, Schwarz CG, Seo SW, Shekari M, Silbert LC, Smith R, Snyder HM, Sokolowski A. JAMA, 2026 Oct 6; 336 (13): 1135 - 1148.Journal ArticleAmyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis
DOI:10.1001/jama.2026.13116 PMID: 42441390 -
Devignes Q, Pruitt PJ, Petscavage K, Koeppe RA, Albin RL, Peltier SJ, Rahman-Filipiak A, Giordani B, Iordan AD, Hampstead BM. Alzheimer S and Dementia, 2026 Oct 1; 22 (10):Journal ArticleBrain microstructure mediates the relationship between Alzheimer's proteinopathies and memory
DOI:10.1002/alz.71899 PMID: 42869850 -
Liu P, Harrison TM, Snyder HM, DeCarli C, Maillard P, Vemuri P, Harvey D, Koeppe R, Jagust W, Baker LD, Landau SM, Alzheimer's Disease Neuroimaging Initiative (ADNI)¹ and the U.S. POINTER Study Group. . Neuroimage Clin, 2026 Sep 18; 52: 104064Journal ArticleAre the factors associated with cognitive performance generalizable across cohorts?
DOI:10.1016/j.nicl.2026.104064 PMID: PMC13631531 -
Buckley RF, Townsend DL, Birkenbihl CJ, Cuppels M, Coughlan GT, Seto MT, Brown JA, Properzi MJ, Hönig MC, Li A, Schultz AP, Chhatwal J, Yang H-S, Arnold S, Kivisäkk P, James BD, O'Bryant S, Rissman RA, Petersen M, Caldwell JZK, Betthauser T, Oomens JE, Carrigan M, Healy B, Condado JG, Johnson SC, Yau W-YW, Langford O, Farrell M, Amariglio RE, Rentz DM, Papp KV, Brookmeyer R, Hohman TJ, Donohue M, Aisen PS, Johnson KA, Sperling RA, Alzheimer’s Disease Neuroimaging Initiative, Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies, Harvard Aging Brain Study (HABS), Health & Aging Brain Study – Health D , Alzheimer’s Disease Neuroimaging Initiative, Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies, Harvard Aging Brain Study (HABS), Health & Aging Brain Study – Health Disparities (HABS-HD), and Wisconsin Registry for Alzheimer’s Prevention (WRAP) . JAMA, 2026 Sep 15; 336 (11): 950 - 959.Journal ArticlePrognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.
DOI:10.1001/jama.2026.12556 PMID: PMC13370474 -
Kim JP, Nho K, Wang T, Huynh K, Arnold M, Risacher SL, Bice PJ, Han X, Kristal BS, Blach C, Baillie R, Kastenmüller G, Meikle PJ, Saykin AJ, Kaddurah-Daouk R, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Risacher SL, Foroud TM, Cairns NJ, Morris J, Rabinovici G, Koeppe RA, DeCarli C, Thompson P, Fox NC, Tosun D, Perrin RJ, Nho K, Green RC, Harvey D, Beckett L, Toga AW, Lee EB, Shaw LM, Okonkwo O, Rivera-Mindt M, Landau S, Jagust W, Jack CR, Petersen R, Aisen P, Weiner M, Sacks F, Foroud T, Hernandez I, Newman J, Suhre K, Krumsiek J, Greenwood A, Koal T, Würtz P, Qiu W, Au R, Farrer L, Brinton R, Wishart D, Jia W, Baloni P, Funk C, Thiele I, Hankemeier T, Ikram A, Vogt R, Keshavarzian A, Krishnan R, Bennett D, Nevado-Holgado A, Amin N, Duijn CV, Shaw L, Rader D, Mazmanian S, Meikle P, Barupal D, Fiehn O, Gupta A, Baldi P, Labus J, Mayer E, Brewer J, Dorrestein P, Knight R, Arnold M, Risacher S, Plassman B, Welsh-Balmer K, Mahmoudiandehkhordi S, Moseley A, Doraiswamy PM, Kueider-Paisley A. Molecular Psychiatry, 2026 Sep 1; 31 (9): 5395 - 5408.Journal ArticleCirculating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer’s disease
DOI:10.1038/s41380-026-03626-z PMID: 42304066