Yaqing Zhang
Research Assistant Professor
Surgery
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[email protected]

Available to mentor
Yaqing Zhang
Research Assistant Professor
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
    • About

    Dr. Zhang, Research Assistant Professor, has been a pancreatic cancer researcher in the Department of Surgery at the University of Michigan since 2010. She joined the laboratory of Dr. Marina Pasca di Magliano as a post-doctoral fellow after receiving her PhD from the Fourth Military Medical University in China. She is also board-certified in Anatomic Pathology in China and has years of experience in surgical and forensic pathology. Dr. Zhang's research focuses on the mechanisms underlying the establishment of immune suppression in pancreatic cancer, with the goal of discovering novel immune-modulatory approaches to effectively treating pancreatic cancer.

    Qualifications
    • Postdoctoral Research Fellow, Pancreatic Cancer
      University of Michigan Medical School, Ann Arbor, 2014
    • Pathology Resident
      Qingdao Municipal Hospital, Department of Pathology, 2002
    • PhD
      Fourth Military Medical University, Xi'an, 2010
    • MS
      Qingdao University Medical College, Qingdao, 2003
    • MB BS
      Qingdao University Medical College, Qingdao, 1997
    Research Overview

    Dr. Zhang's research interests include: 1) crosstalk between tumor cells and different types of stromal cells during both pancreatic cancer initiation and progression; 2) metabolic regulation of immunosuppressive myeloid cells in the tumor microenvironment of pancreatic cancer; 3) targeting the immunosuppressive microenvironment as a therapeutic strategy in pancreatic cancer.

    Recent Publications See All Publications
    • Presentation
      CCR1 drives immunosuppressive properties of tumor associated macrophages in pancreatic cancer.
      Zhang Y. 2024 Nov 18;
    • Journal Article
      Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth.
      Donahue KL, Watkoske HR, Kadiyala P, Du W, Brown K, Scales MK, Elhossiny AM, Espinoza CE, Lasse Opsahl EL, Griffith BD, Wen Y, Sun L, Velez-Delgado A, Renollet NM, Morales J, Nedzesky NM, Baliira RK, Menjivar RE, Medina-Cabrera PI, Rao A, Allen B, Shi J, Frankel TL, Carpenter ES, Bednar F, Zhang Y, Pasca di Magliano M. Cancer Discov, 2024 Oct 4; 14 (10): 1964 - 1989. DOI:10.1158/2159-8290.CD-24-0100
      PMID: 38958646
    • Preprint
      WITHDRAWN: Oncogenic KRASG12D extrinsically induces an immunosuppressive microenvironment in lung adenocarcinoma
      Lasse-Opsahl E, Baliira R, Barravecchia I, McLintock E, Lee JM, Ferris SF, Espinoza CE, Hinshaw R, Cavanaugh S, Robotti M, Brown K, Donahue K, Abdelmalak KY, Galban CJ, Frankel TL, Zhang Y, di Magliano MP, Galban S. bioRxiv, DOI:10.1101/2024.01.16.568090
    • Journal Article
      Notch Signaling Regulates Immunosuppressive Tumor-Associated Macrophage Function in Pancreatic Cancer.
      Yan W, Menjivar RE, Bonilla ME, Steele NG, Kemp SB, Du W, Donahue KL, Brown KL, Carpenter ES, Avritt FR, Irizarry-Negron VM, Yang S, Burns WR, Zhang Y, Pasca di Magliano M, Bednar F. Cancer Immunol Res, 2024 Jan 3; 12 (1): 91 - 106. DOI:10.1158/2326-6066.CIR-23-0037
      PMID: 37931247
    • Journal Article
      Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
      Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen C-T, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M. Cancer Discov, 2023 Jun 2; 13 (6): 1324 - 1345. DOI:10.1158/2159-8290.CD-23-0013
      PMID: 37021392
    • Journal Article
      Arginase 1 is a key driver of immune suppression in pancreatic cancer.
      Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M. Elife, 2023 Feb 2; 12: DOI:10.7554/eLife.80721
      PMID: 36727849
    • Preprint
      Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions.
      Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith B, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske H, Mattea M, The S, Espinoza C, Barrett M, Sonnenday CJ, Olden N, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Di Magliano MP. 2023 Jan 15; DOI:10.1101/2023.01.13.523300
      PMID: 36712058
    • Preprint
      Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer.
      Yan W, Steele NG, Kemp SB, Menjivar RE, Du W, Carpenter ES, Donahue KL, Brown KL, Irizarry-Negron V, Yang S, Burns WR, Zhang Y, di Magliano MP, Bednar F. 2023 Jan 13; DOI:10.1101/2023.01.11.523584
      PMID: 36711890