![A biochemistry researcher examines a specimen in the lab](https://medschool.umich.edu/sites/default/files/styles/large_16_9/public/2023-11/FinalBioChemResearchHeroPhoto.jpg?h=50c77c9c&itok=NYDGzIJS)
Asking and Answering Fundamental Questions
We explore biological phenomena at the molecular and mechanistic levels to make discoveries about life and health.
Scientists in the Department of Biological Chemistry integrate many technologies and approaches to study the molecular processes that are the foundation for life and health. Research projects can be grouped into the four broad areas of Biochemical Signaling, Macromolecular Structure & Mechanism, Protein Processing & Folding and Regulation of Gene Expression.
Close ties and cross-appointments with the Life Sciences Institute, the Michigan Neuroscience Institute, the Chemical Biology Program, the LSA departments of Biology, Biophysics, and Chemistry, as well as fellow Medical School departments, position Biological Chemistry at the center of a strong and diverse biochemical community at the University of Michigan.
Our interdisciplinary research into the molecular mechanisms of life offers a wide variety of investigative opportunities to students, fellows, and scientific collaborators.
![man using pipette in laboratory](https://medschool.umich.edu/sites/default/files/styles/card/public/2023-06/bioChem-manHoldingPipette%20%281%29.jpg?h=3d1c8f56&itok=8lk_Z0BU)
Probe how cells respond to changes in their environment.
![man in labradory pouring liquid into a tank](https://medschool.umich.edu/sites/default/files/styles/card/public/2023-06/bioChem-manInlLab.jpg?h=cfc81ebe&itok=iYIYM0CR)
Focus in on how biological macromolecules function at the molecular and atomic level.
![woman in a laboratory is leaned over while operating a microscope](https://medschool.umich.edu/sites/default/files/styles/card/public/2023-06/bioChem-womenWithMicroscope.jpg?h=22d84a31&itok=5fO5s2vO)
Understanding the folding, translocation, and processing of proteins is integral to modern molecular and cell biology.
![students in a lab working and wearing latex gloves](https://medschool.umich.edu/sites/default/files/styles/card/public/2023-06/bioChem-labStudents.jpg?h=9cb56001&itok=MNsc9man)
Use and develop groundbreaking research techniques to uncover the mechanisms that govern gene expression.
![suzanne admiraal](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-suzanne-admiraal-profile.jpg?itok=02D0FK0V)
Patrick O'Brien Lab
![sojin an](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-sojin-an-profile.jpg?itok=Nm74xjXM)
Uhn-Soo Cho Lab
![Catherine baker](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-catherine-baker-profile.jpg?itok=ZNABKOkh)
James Morrissey Lab
![Michael Baldwin](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-michael-baldwin-profile.jpg?itok=K-Fgnio3)
Patrick O'Brien Lab
![Brittney bowman](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-brittany-bowman-profile.jpg?itok=HbngQ_w-)
Chase Weidmann Lab
![jue chen](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-jue-chen-profile.jpg?itok=IoT3uTci)
Yan Zhang Lab
![Daniel esckilsen](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-daniel-esckilsen-profile.jpg?itok=2iTBkajk)
Stephen Ragsdale Lab
![user](https://medschool.umich.edu/modules/custom/outline_design_system/assets/images/issue-default-graphic.png)
Raymond Trievel Lab
![Rachel hemp](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-rachel-hemp-profile.jpg?itok=pfCRU9rb)
James Morrissey Lab
![rebecca hurto](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-rebecca-hurto-profile.jpg?itok=fcxpSV1B)
Lydia Freddolino Lab
![zhu li](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-zhu-li-profile.jpg?itok=R9iL0cnI)
Ruma Banerjee Lab
![manolo plasencia](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-manolo-plasencia-profile.jpg?itok=WVpmEtlo)
Lydia Freddolino Lab
![headshot of krishna-rengasamy](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-11/biochem-krishna-rengasamy-profile.jpeg?itok=jSoF00sZ)
Uhn-Soo Cho Lab
![Andrew shurer](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-andrew-shurer-profile.jpg?itok=bBV9cmmr)
Rachel Niederer Lab
![user](https://medschool.umich.edu/modules/custom/outline_design_system/assets/images/issue-default-graphic.png)
Ryan Baldridge Lab
![user](https://medschool.umich.edu/modules/custom/outline_design_system/assets/images/issue-default-graphic.png)
Ruma Banerjee Lab
![xufei zhou](https://medschool.umich.edu/sites/default/files/styles/wide/public/2023-10/biochem-xufei-zhou-profile.jpg?itok=B3TUyyoF)
Yan Zhang Lab
![Headshots of two new Genetics Training Program members](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-07/biochem-7-22-24-article.jpg?h=b4f59d0b&itok=m7jQl-_7)
![headshot of Jenna Veenstra](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-07/biochem-7-15-24-article-1.jpg?h=08b866d1&itok=ium9in5K)
![headshot of Cassandra Dutcher](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-07/biochem-7-15-24-article-2.jpg?h=08b866d1&itok=MVxYY_at)
![Headshot of Renke Tan](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-07/biochem-7-5-24-article.jpg?h=08b866d1&itok=o9cWqhek)
![Headshot of Michael Uhler](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-06/biochem-7-1-24-article.jpg?h=08b866d1&itok=ihgSIL1Y)
![Headshots of three PhD students](https://medschool.umich.edu/sites/default/files/styles/card/public/2024-06/biochem-6-21-24-article.jpg?h=b4f59d0b&itok=VM-5Pres)