Biological Chemistry Research
A biochemistry researcher examines a specimen in the lab

Asking and Answering Fundamental Questions

We explore biological phenomena at the molecular and mechanistic levels to make discoveries about life and health.

Understanding the Foundations of Life

Scientists in the Department of Biological Chemistry integrate many technologies and approaches to study the molecular processes that are the foundation for life and health. Research projects can be grouped into the four broad areas of Biochemical Signaling, Macromolecular Structure & Mechanism, Protein Processing & Folding and Regulation of Gene Expression.

Close ties and cross-appointments with the Life Sciences Institute, the Center for RNA Biomedicine, the Michigan Neuroscience Institute, the Chemical Biology Program, and the LSA departments of Biology, Biophysics, and Chemistry place Biological Chemistry at the center of the University of Michigan's strong biochemical community. 

Our interdisciplinary research into the molecular mechanisms of life offers a wide variety of investigative opportunities to students, fellows, and scientific collaborators.

Research Areas
man using pipette in laboratory
Biochemical Signaling

Probe how cells respond to changes in their environment.

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Macromolecular Structure & Mechanism

Focus in on how biological macromolecules function at the molecular and atomic level.

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Protein Processing & Folding

Understanding the folding, translocation, and processing of proteins is integral to modern molecular and cell biology.

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Regulation of Gene Expression

Use and develop groundbreaking research techniques to uncover the mechanisms that govern gene expression.

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Biological Chemistry News & Stories See all news National Science Foundation logo
Department News
Six PhD students in Biological Chemistry labs receive honors from the National Science Foundation
Six students affiliated with the U-M Department of Biological Chemistry have been recognized by the National Science Foundation
headshot Seokmu Kwon
Department News
Chemical Engineering PhD student Seokmu Kwon of the Giessen lab receives two awards
U-M Chemical Engineering PhD student Seokmu Kwon of the Giessen lab receives honors.
headshot of Jeanne Stuckey
Department News
Jeanne Stuckey, PhD, is honored with a student-nominated teaching award
Research Professor Jeanne Stuckey of the Department of Biological Chemistry at U-M Medical School is a 2025 recipient of an Honored Instructor Award sponsored by Michigan Housing.
American Society for Clinical Investigation logo
Medical School News
Three Medical School faculty members receive Young Physician-Scientist Awards from American Society for Clinical Investigation
Three Medical School faculty members are among a group of 50 nationwide to receive Young Physician-Scientist Awards from the American Society for Clinical Investigation. Nora V. Becker, M.D., Ph.D., an assistant professor of internal medicine in the Division of General Medicine; Wassim Walid Labaki, M.D., M.S., an assistant professor of internal medicine in the Division of Pulmonary and Critical Care Medicine; and John R. Prensner, M.D., Ph.D., an assistant professor of pediatrics and biological chemistry, are recipients of the annual award, which recognizes physician-scientists who are within 1-5 years of their first faculty appointment and have made notable achievements in their research.
atomic-level model of membrane-bound complex that triggers blood coagulation
Department News
The Morrissey lab publishes research in Blood Advances that is featured on the journal's cover
The Morrissey lab from U-M Biological Chemistry publishes a research article in Blood Advances.
headshot of Yulduz Rakibova
Department News
Congratulations to Yulduz Rakibova, PhD
Biological Chemistry PhD student Yulduz Rakibova of the Freddolino lab defends her doctoral dissertation.