![gloved hands squeeze sample into tray](https://medschool.umich.edu/sites/default/files/styles/large_16_9/public/2024-03/AdobeStock_378582704.jpeg?h=335efa0a&itok=1aF9OvJw)
The Billi lab is exploring how the female-biased transcription coregulator VGLL3 promotes autoimmune diseases such as lupus, through interaction with transcription factors that are shared by the Hippo signaling pathway. This work uses human cell culture, mouse models of inflammatory skin disease, single-cell RNA-seq and systems biology approaches.
We are investigating the biological mechanisms leading to female sex bias in lupus, including studies examining how the VGLL3 drives autoimmune disease in the skin of women. Our research employs mouse modeling of complex human disease and systems biology approaches for study of cutaneous and systemic immunology.
We are collaborating on studies using bioinformatics analysis of multi-omics datasets to explore the complex regulatory mechanisms that drive and perpetuate rare and common inflammatory skin diseases. We have recently shown that psoriasis-like skin inflammation can trigger inflammatory joint disease in mice.
![Allison Billi](https://medschool.umich.edu/sites/default/files/styles/wide/public/2024-04/Derm_Billi_Allison.png?itok=TEBSy4sT)
![Vincent Drongelen](https://medschool.umich.edu/sites/default/files/styles/wide/public/2024-04/Derm_van%20Drongelen_Vincent.png?itok=5EVGIYgE)
Dermatology
Check out our publications on Sex Discrepancy in Autoimmune Disease.