Charles Matrosic, PhD

Charles K. Matrosic
Clinical Assistant Professor of Radiation Oncology
Medical School
University of Michigan
Department of Radiation Oncology - Michigan Medicine
1500 E. Medical Center Drive
Ann Arbor, Michigan 48103-5010
[email protected]
Available to mentor
Charles Matrosic, PhD
Charles K. Matrosic
Clinical Assistant Professor
  • Qualifications
  • Research Overview
  • Recent Publications
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  • Qualifications

    • Therapeutic Medical Physics Residency
      University of Michigan–Ann Arbor, Department of Radiation Oncology, Ann Arbor, United States
      2019 - 2021
      Residency
    • Ph.D., Medical Physics
      University of Wisconsin, Madison, Wisconsin, United States
      2016 - 2019
    • M.S., Medical Physics
      University of Wisconsin, Madison, Wisconsin, United States
      2014 - 2016
    • B.S.E., Nuclear Engineering and Radiological Sciences – Physics Minor
      University of Michigan, Ann Arbor, Michigan, United States
      2010 - 2014

    Research Overview

    Clinical Interests
    · External Beam Radiotherapy Treatment Planning: I am regularly involved in physics treatment plan checks to ensure treatment quality and safety and am a member of the Dosimetry Affinity Group. I am also the physics co-lead of the lung treatment site and help improve treatment planning procedures, practices, and documentation for the site.
    · Special Medical Physics Consultation (SMPC): I regularly cover SMPCs for patient reirradiation cases, which involves estimating patient cumulative doses incorporating potential repair of damage from previous treatments and estimating new healthy tissue dose limits based on these cumulative doses.
    · Brachytherapy: I am a member of my department’s Brachytherapy Affinity Group, participate regularly in HDR and LDR treatments, and am the lead physicist for the I-125 Eye Plaque service at the University of Michigan Department of Radiation Oncology.
    Research Interests
    · Lung function imaging and its implementation in radiotherapy and treatment planning
    · Reirradiation and the technologies and workflows required to manage reirradiation patients
    · The implementation of knowledge-based planning as a quality assurance tool in radiotherapy treatment planning
    · The implementation of advanced radiotherapy treatment planning techniques into clinical practice

    Recent Publications

    See All Publications
    • Presentation
      Scaling safe reirradiation: Lessons learnt from streamlining reirradiation in a high-volume US centre
      Matrosic C. 2026 Jan 27;
    • Presentation
      Integrating Functional Lung Imaging and Parametric Response Mapping into Thoracic Radiation Therapy
      Matrosic C. 2026 Apr 28;
    • Journal Article
      A Case-Based Guide: Demonstrating the ReCOG Consensus for Dosimetric Assessment and Reporting in Reirradiation.
      Zhang C, Mayo CS, Matrosic CK, Chang DT, Chng N, Dess RT, Evans JR, Gabryś D, Heron DE, Hoffmann L, Jackson WC, Matuszak MM, Prisciandaro JI, Rosen BS, Salerno KE, Simone CB, Xiao Y, Paradis KC. Pract Radiat Oncol, 2026 Apr 13; DOI:10.1016/j.prro.2026.03.010
      PMID: 41985779
    • Proceeding / Abstract / Poster
      Adding It Up: Past, Present, and Future of Re-RT Workflows
      Matrosic C. 2026 Feb 21;
    • Preprint
      AI-Driven Troubleshooting for TrueBeam Systems: Development and Testing of a GPT-4.1 Chatbot
      Knill C, Devan S, Matrosic CK, Moreau J, Zhang Z. 2026 Apr 23; Elsevier BV, DOI:10.2139/ssrn.6631202
    • Journal Article
      Thoracic reirradiation clinical and technical practices: a survey from the reirradiation Collaborative Group (ReCOG).
      Matuszak MM, Simone Ii CB, Matrosic CK, Owen D, Shepherd AF, Appelt A, Mayo C, Paradis KC, Yorke E, Andratschke N. Clin Transl Radiat Oncol, 2026 Jan; 56: 101042 DOI:10.1016/j.ctro.2025.101042
      PMID: PMC12495242
    • Presentation
      Workflows for Treatment Planning and Dose Evaluation for Re-Irradiation
      Matrosic C. 2025 Dec 5;
    • Presentation
      What’s new in reirradiation in 2025?
      Matrosic C. 2025 Oct 16;