Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]
Available to mentor
Shaomeng Wang
Professor
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
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Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Neoplasia, 2024 May; 51: 100986Journal ArticleCorrigendum to 'Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment' Neoplasia, Volume 22, Issue 2 (2020) 111-119.
DOI:10.1016/j.neo.2024.100986 PMID: 38492449 -
Chen Z, Wang M, Wu D, Bai L, Xu T, Metwally H, Wang Y, McEachern D, Zhao L, Li R, Takyi-Williams J, Wang M, Wang L, Li Q, Wen B, Sun D, Wang S. J Med Chem, 2024 Apr 11; 67 (7): 5275 - 5304.Journal ArticleDiscovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression.
DOI:10.1021/acs.jmedchem.3c02124 PMID: 38477974 -
Chen Z, Wang M, Wu D, Zhao L, Metwally H, Jiang W, Wang Y, Bai L, McEachern D, Luo J, Wang M, Li Q, Matvekas A, Wen B, Sun D, Chinnaiyan AM, Wang S. J Med Chem, 2024 Apr 11; 67 (7): 5351 - 5372.Journal ArticleDiscovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer.
DOI:10.1021/acs.jmedchem.3c01789 PMID: 38530938 -
Marella S, Sharma A, Ganesan V, Ferrer-Torres D, Krempski JW, Idelman G, Clark S, Nasiri Z, Vanoni S, Zeng C, Dlugosz AA, Zhou H, Wang S, Doyle AD, Wright BL, Spence JR, Chehade M, Hogan SP. J Allergy Clin Immunol, 2023 Dec; 152 (6): 1550 - 1568.Journal ArticleIL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis.
DOI:10.1016/j.jaci.2023.07.021 PMID: 37652141 -
Rasool RU, O'Connor CM, Das CK, Alhusayan M, Verma BK, Islam S, Frohner IE, Deng Q, Mitchell-Velasquez E, Sangodkar J, Ahmed A, Linauer S, Mudrak I, Rainey J, Zawacki KP, Suhan TK, Callahan CG, Rebernick R, Natesan R, Siddiqui J, Sauter G, Thomas D, Wang S, Taylor DJ, Simon R, Cieslik M, Chinnaiyan AM, Busino L, Ogris E, Narla G, Asangani IA. Nat Commun, 2023 Aug 29; 14 (1): 5253Journal ArticleLoss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
DOI:10.1038/s41467-023-40760-6 PMID: 37644036 -
Zheng C, Rej RK, Wang M, Huang L, Fernandez-Salas E, Yang C-Y, Wang S. ACS Med Chem Lett, 2023 Oct 12; 14 (10): 1389 - 1395.Journal ArticleDiscovery of Pyrrolo[2,3-c]pyridines as Potent and Reversible LSD1 Inhibitors.
DOI:10.1021/acsmedchemlett.3c00292 PMID: 37849536 -
Xiang W, Zhao L, Han X, Xu T, Kregel S, Wang M, Miao B, Qin C, Wang M, McEachern D, Lu J, Bai L, Yang C-Y, Kirchhoff PD, Takyi-Williams J, Wang L, Wen B, Sun D, Ator M, Mckean R, Chinnaiyan AM, Wang S. J Med Chem, 2023 Sep 28; 66 (18): 13280 - 13303.Journal ArticleDiscovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer.
DOI:10.1021/acs.jmedchem.3c01264 PMID: 37683104 -
Chen Z, Hu B, Rej RK, Wu D, Acharyya RK, Wang M, Xu T, Lu J, Metwally H, Wang Y, McEachern D, Bai L, Gersch CL, Wang M, Zhang W, Li Q, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2023 Sep 14; 66 (17): 12559 - 12585.Journal ArticleDiscovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity.
DOI:10.1021/acs.jmedchem.3c01186 PMID: 37647546
