Daniel R Wahl, MD, PhD
Associate Professor of Radiation Oncology and Associate Professor of Neurosurgery
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
[email protected]

Available to mentor
Daniel R Wahl, MD, PhD
Associate Professor
  • About
  • Links
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.

    Links
    • Wahl Lab
    • Personal page on department website
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.

    Recent Publications See All Publications
    • Journal Article
      Olaparib and Radiotherapy Induce Type I Interferon- and CD8+ T Cell-Dependent Sensitization to Immunotherapy in Pancreatic Cancer.
      Valvo VM, Zhang Q, Jiang L, Holcomb EA, Pearson AN, Edmunds AG, Faulkner HG, James JG, Tate A, Huber AK, Wang Z, Guo Y, Karnak D, Parsels LA, Parsels JD, Lei YL, Rehemtulla A, Lin H, Carpenter ES, Wahl DR, Sahai V, Lawrence TS, Green MD, Morgan MA. Mol Cancer Ther, 2024 Dec 17; OF1 - OF16. DOI:10.1158/1535-7163.MCT-24-0210
      PMID: 39688341
    • Presentation
      Measuring and targeting altered metabolism in brain cancer
      Wahl D. 2024 Dec 9;
    • Journal Article
      Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma.
      Mbah NE, Myers AL, Sajjakulnukit P, Chung C, Thompson JK, Hong HS, Giza H, Dang D, Nwosu ZC, Shan M, Sweha SR, Maydan DD, Chen B, Zhang L, Magnuson B, Zhu Z, Radyk M, Lavoie B, Yadav VN, Koo I, Patterson AD, Wahl DR, Franchi L, Agnihotri S, Koschmann CJ, Venneti S, Lyssiotis CA. Nat Commun, 2024 Oct 17; 15 (1): 8983 DOI:10.1038/s41467-024-52973-4
      PMID: 39419964
    • Preprint
      Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma.
      Korimerla N, Meghdadi B, Haq I, Wilder-Romans K, Xu J, Becker N, Zhu Z, Kalev P, Qi N, Evans C, Kachman M, Zhao Z, Lin A, Scott AJ, O'Brien A, Kothari A, Sajjakulnukit P, Zhang L, Palavalasa S, Peterson ER, Hyer ML, Marjon K, Sleger T, Morgan MA, Lyssiotis CA, Stone EM, Ferris SP, Lawrence TS, Nagrath D, Zhou W, Wahl DR. 2024 Nov 21; DOI:10.1101/2024.11.20.624542
      PMID: 39651281
    • Journal Article
      CTNI-19. MYCOPHENOLATE MOFETIL TARGETS GLIOBLASTOMA DE-NOVO PURINE METABOLISM TO OVERCOME CHEMORADIATION RESISTANCE IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
      Umemura Y, Clarke N, Al-Holou W, Elaimy A, Scott A, Leung D, Kim M, Ferris S, Thomas J, Heth J, Schipper M, Suresh K, Lawrence T, Wahl D. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii99 - viii100. DOI:10.1093/neuonc/noae165.0386
    • Journal Article
      DNAR-08. THY1 MEDIATES TREATMENT RESISTANCE IN GLIOBLASTOMA THROUGH RAPID REPAIR OF DNA DAMAGE
      Syed SB, Tripathy A, Ravikumar V, Awadia S, Palavalasa S, Huang D-L, Rao A, Wahl DR, Rehemtulla A, Al-Holou WN. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii118 - viii119. DOI:10.1093/neuonc/noae165.0459
    • Journal Article
      IMMU-04. G-AMINOBUTYRIC ACID DRIVES GLIOBLASTOMA IN FEMALES IN AN IMMUNE-DEPENDENT MANNER
      Pathak A, Palavalasa S, Ciervo E, Van Den Knott MB, Susic N, Shah KH, Colon B, Chin D, Zhou Y, Cheng F, Lyssiotis C, Watson DC, Wahl D, Ceccarelli M, Shah A, Lathia JD, Bayik D. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii152 - viii152. DOI:10.1093/neuonc/noae165.0597
    • Journal Article
      TMET-27. MACHINE LEARNING-BASED IDENTIFICATION OF METABOLIC FLUXES IN PATIENT BRAIN TUMORS
      Meghdadi B, Mittal A, Scott A, Liang N, Palavalasa S, Achreja A, Kothari AOA, Zhou W, Xu J, Lin A, Wilder-Romans K, Edwards D, Wu Z, Feng J, Andren A, Zhang L, Tarnal V, Redic K, Qi N, Lawrence T, Lyssiotis C, Al-Holou W, Wahl D, Nagrath D. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii294 - viii294. DOI:10.1093/neuonc/noae165.1165