Daniel R Wahl, MD, PhD
Associate Professor
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
[email protected]

Available to mentor
Daniel R Wahl, MD, PhD
Associate Professor
  • About
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  • Research Overview
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    About

    Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.

    Links
    • Wahl Lab
    • Personal page on department website
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.

    Recent Publications See All Publications
    • Preprint
      Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival
      Torres M, Lu Y, Pederson B, Wang H, Gretzinger A, Lin LL, Hwang J, Rupp A, Tomlinson A, Scott AJ, Zhao Z, Wahl DR, Myers M, Lyssiotis CA, Qi L. 2025 Jun 20; bioRxiv, DOI:10.1101/2025.06.16.659938
    • Preprint
      A New Tool to Decrease Interobserver Variability in Biomarker Annotation in Solid Tumor Tissue for Spatial Transcriptomic Analysis
      Palavalasa S, Baker E, Freeman J, Gokul A, Zhou W, Thomas D, Al-Holou W, Morgan MA, Lawrence TS, Wahl DR. 2025 Jun 18; Preprints.org, DOI:10.20944/preprints202506.1311.v1
    • Journal Article
      Olaparib and Radiotherapy Induce Type I Interferon– and CD8+ T Cell–Dependent Sensitization to Immunotherapy in Pancreatic Cancer
      Valvo VM, Zhang Q, Jiang L, Holcomb EA, Pearson AN, Edmunds AG, Faulkner HG, James JG, Tate A, Huber AK, Wang Z, Guo Y, Karnak D, Parsels LA, Parsels JD, Lei YL, Rehemtulla A, Lin H, Carpenter ES, Wahl DR, Sahai V, Lawrence TS, Green MD, Morgan MA. Molecular Cancer Therapeutics, 2025 Jun 1; 24 (6): 843 - 858. DOI:10.1158/1535-7163.MCT-24-0210
      PMID: 39688341
    • Proceeding / Abstract / Poster
      Abstract 1140: Digital twins for in vivo metabolic flux estimations in brain cancer patients
      Meghdadi B, Al-Holou WN, Scott AJ, Mittal A, Liang N, Palavalasa S, Achreja A, Qi N, O'Brien A, Tarnal V, Zhou W, Lawrence TS, Lyssiotis CA, Wahl DR, Nagrath D. Cancer Research, 2025 Apr 24; 85 (8_Supplement_1): 1140 - 1140. DOI:10.1158/1538-7445.am2025-1140
    • Journal Article
      Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
      Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, Groot JD, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, Nava DDL, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. Cancer Discovery, 2025 Mar 1; 15 (3): 657 DOI:10.1158/2159-8290.CD-25-0208
      PMID: 40025951
    • Additional Scholarship
      Supplementary Data S1 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
      Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, de la Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. 2025 Feb 18; DOI:10.1158/2159-8290.28436530
    • Additional Scholarship
      Supplementary Data S2 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
      Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, de la Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. 2025 Feb 18; DOI:10.1158/2159-8290.28436527
    • Additional Scholarship
      Supplementary Figures 1-15 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
      Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, de la Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. 2025 Feb 18; DOI:10.1158/2159-8290.28436524
    Featured News & Stories The Achtenberg family dressed in Michigan gear at University Hospital.
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